Repeated-load testing of schist and limestone aggregate materials used in unbound forest roads

This study examined the behaviour of two completion aggregates that were placed on a silty sandy formation material and subjected to repeated loading in a large-scale testing rig. The completion aggregates were (i) a good quality limestone, and (ii) a poor quality schist, and are used in the construction of unbound forest roads in Ireland. The schist was tested on its own and in combination with the completion limestone aggregate for up to 150,000 load applications with a maximum loading pressure of 1000 kPa. Measurements of surface deflections and formation pressures were made during each test. A combination of a 200 mm layer of the limestone aggregate placed on top of a 250 mm layer of the schist aggregate produced the lowest permanent deformations, resilient deflections, and resilient pressures under dry and wet undrained conditions.     

C-terminal processing of yeast Spt7 occurs in the absence of functional SAGA complex

Background  

Spt7 is an integral component of the multi-subunit SAGA complex that is required for the expression of ~10% of yeast genes. Two forms of Spt7 have been identified, the second of which is truncated at its C-terminus and found in the SAGA-like (SLIK) complex.     

Rhodium perfluorobutyramide (Rh2(pfm)4): a synthetically useful catalyst for olefin aziridinations

Rhodium perfluorobutyramide (Rh₂(pfm)₄) has been shown to catalyze the conversion of olefins to trichloroethoxysulfonyl, nosyl, and tosyl aziridines. Advantages of this aziridination procedure include the microwave-assisted preparation of the catalyst and the practical use of the alkene substrate as the limiting reagent.     

Total synthesis of (+/-)-kalihinol C

The total synthesis of kalihinol C, a bis-isonitrile marine diterpenoid isolated from Acanthella sp., is reported. The decalin framework was established via an intramolecular Diels-Alder cycloaddition and subsequently functionalized through a series of substrate-controlled diastereoselective transformations to install the tertiary isonitrile, beta-hydroxy isonitrile, and pendant tetrahydrofuranyl ring.     

Solution-phase library synthesis of furanoses

The solution-phase synthesis of amido-, urea-, and aminofuranoses was achieved. Alkylated furanose aldehydes were treated with primary amines in the presence of sodium triacetoxyborohydride to give secondary amines. Subsequent acylation with acid chlorides and isocyanates afforded amidofuranoses and ureafuranoses, respectively. Second, reductive amination of furanose aldehydes with secondary amines yielded tertiary amines. The resulting acetonides were treated with alcohols in the presence of acid to yield mixed acetals. In the library syntheses, functionalized scavenger resins were used in the purification of intermediates and products.