1-Carbamoylhydantoins. New Aspects of Reactivity

Russian Journal of Organic Chemistry - Some derivatives of 1-carbamoylhydantoins undergo cleavage at the N1–C(O) bond on heating in solution. 1-Carbamoylhydantoins in aqueous and alcoholic...     

Synthesis of substituted 2-(2-oxopyrrolidin-1-yl)acetamides

The reaction of chloroacetamide with 2 equiv of γ-aminobutyric acid potassium salts provides a convenient method for the synthesis of substituted 4-[(2-amino-2-oxoethyl)amino]butanoic acids. Alkylation products of 2-aminoacetic and 3-aminopropanoic acid with chloroacetamide were isolated. Thermal cyclization of substituted 4-[(2-amino-2-oxoethyl)amino]butanoic acids afforded 2-(2-oxopyrrolidin-1-yl)acetamides.     

Fused Imidazoles: I. Synthesis of 6,7-Dihydro-5<Emphasis Type="Italic">H</Emphasis>-pyrrolo[1,2-<Emphasis Type="Italic">a</Emphasis>]imidazole Derivatives

Dehydration of substituted 2-(2-oxopyrrolidin-1-yl)acetamides with phosphoryl chloride provides a convenient method of synthesis of 2-chloro-6,7-dihydro-5H-pyrrolo[1,2-a]imidazoles. The latter can be readily converted to various derivatives via introduction and modification of a substituent in the 3-position. The chlorine atom in the 2-position can be removed by hydrogenation over Raney nickel.     

Fused Imidazoles: II. Synthesis of Nitro Derivatives of 6,7-Dihydro-5H-pyrrolo[1,2-a]imidazoles

Russian Journal of Organic Chemistry - Nitration of 6-substituted 2-chloro-6,7-dihydro-5H-pyrrolo[1,2-a]imidazoles was used to synthesize the corresponding 3-nitro derivatives. 6-Substituted...     

2,2′,2″-(2,4,6-Trioxo-1,3,5-triazinane-1,3,5-triyl)triacetic Acid Derivatives. New Aspects of Reactivity

Russian Journal of Organic Chemistry - Reaction of 2,2′,2″-(2,4,6-trioxo-1,3,5-triazinane-1,3,5-triyl)triacetic acid derivatives with nucleophiles in aqueous medium involved opening of...