Many-body systems and the Efimov effect

We employ a Birman-Schwinger type analysis to derive estimates on the number of bound-states of certainN-body systems with threshold-energy =inf _ess(H) supposed to be zero. For many-body systems without any substructure we show that eigenvalues of the Schrödinger operatorH absorbed at =0 are in the point-spectrum ofH. Furthermore we characterize a multiparticle equivalent of the Efimov effect.     

A novel technique to specifically analyze the secretome of cells and tissues

The secretome of cells and tissues may reflect a broad variety of pathological conditions and thus represents a rich source of biomarkers. The identity of secreted proteins, usually isolated from cell supernatants or body fluids, is hardly accessible by direct proteome analysis, because these proteins are often masked by high amounts of proteins actually not secreted by the investigated cells. Here, we present a novel method for the specific detection of proteins secreted by human tissue specimen as well as cultured cells and chose liver as a model. The method is based on the metabolic labelling of proteins synthesized during a limited incubation period. Then, the cell supernatant is filtered, precipitated, and subjected to two-dimensional gel electrophoresis. Whereas fluorography detected a large number of proteins derived from residual plasma and dead cells, the autoradiographs selectively displayed genuinely secreted proteins. We demonstrate the feasibility of this approach by means of the secretomes of the hepatocellular carcinoma-derived cell line HepG2 and human liver slices. The selective identification of cell- and tissue-specific protein secretion profiles may help to identify novel sets of biomarkers for wide clinical applications.     

Water intake of cellulose materials monitored by positron annihilation lifetime spectroscopy

Cellulose - In this study, for the first time, the experimental technique of positron annihilation lifetime spectroscopy (PALS) has been applied to monitor in situ the microstructural changes of...     

On the quantum Fermi accelerator and its relevance to ‘quantum chaos’

We discuss a quantum version of the Fermi acceleration model, which consists of a particle bouncing between a fixed and oscillating wall. The actual movement of the particle crucially depends on the boundary conditions of the Schrödinger equation. Under Dirichlet boundary conditions, the quantum system displays a regular behaviour, but its classical limit exhibits some unphysical attributes. Only for certain initial conditions does it correspond to the stable motion of a ball bouncing once for an integer number of wall oscillations. In the classical model that situation gives rise to regular islands imbedded in the chaotic sea.     

Microwave-assisted parallel synthesis of fused heterocycles in a novel parallel multimode reactor

New rotor types using disposable glass vials for small-scale parallel synthesis in multimode microwave reactors are introduced. One rotor comprises 16 groups of four vials, whereas the second uses four silicon carbide plates with a 6 x 4 matrix to process the vials. Both rotors achieve utmost temperature homogeneity upon microwave irradiation and can be used for microwave-mediated reactions at temperatures of up to 200 degrees C and pressures of 20 bar. The generation of three different heterocycle libraries furnishing thiophenes, oxindoles, and benzimidazoles using the new rotor types is described.     

Pulsed laser photothermal displacement spectroscopy for surface studies

The feasibility of pulsed laser photothermal displacement spectroscopy for surface studies is demonstrated. With this method transient heating phenomena can be investigated. The technique provides a real-time, non-contact and non-destructive probe of the surface temperature and can be used to study thermal properties and their changes, e.g. during pulsed laser annealing. Possible applications also include investigations of thin films and adsorbates in ultrahigh vacuum as well as in other environments.First results of these experiments have been reported at the Spring Meeting on Surface Physics of the German Physical Society in Bayreuth, March 25–29, 1985     

δ-Santalolanaloga II Synthesen in der Isocamphanreihe, 28. Mitt.

The synthesis of 3-(3,3-dimethyl-2-exo-norbornyl)-2-methylprop-2-en-1-ol (3) and of 8-hydroxymethyl-8-methylcamphene (4) is described.3 and4 are analogues of -Santalol (1) with the allylic hydroxyl group in a position of two or three carbon atoms closer to the bicyclic nucleus compared to1. 4 is also an analogue to Patchenol® which is used sometimes to blend the patchouli oil. The odour impression of these compounds, of the pureendo-epimer of3, and of theendo-exo-mixture of3 are described and compared with the odour of1 and a further analogue whose synthesis has already been reported in a preceding paper [1].

Auszugsweise vorgetragen auf der gemeinsamen wissenschaftlichen Tagung der ÖPhG und DPhG am 11. September 1986 in Innsbruck. Die Synthese von4 wurde bereits am 15. März 1983 anläßlich des 9th International Congress of Essential Oils in Singapore vorgestellt.     

Quantum and Classical Evolutions of a Nonautonomous Dynamical System—A Comparison

The influence of moving boundaries on the stability of quantum Hamiltonian systems, in particular on the dynamics of quantum versions of the classical Pustilnikov model, is investigated (the latter consists of a masspoint bouncing above an oscillating plate under the influence of constant gravity.) It is shown that, in contrast to the classical Pustilnikov model, generic time-periodic boundary conditions (including the Dirichlet condition) on the quantum models do not allow unlimited energy gain (speeding up) of these systems.     

Nanopharmacological Force Sensing to Reveal Allosteric Coupling in Transporter Binding Sites

Controversy regarding the number and function of ligand binding sites in neurotransmitter/sodium symporters arose from conflicting data in crystal structures and molecular pharmacology. Here, we have designed novel tools for atomic force microscopy that directly measure the interaction forces between the serotonin transporter (SERT) and the S‐ and R‐enantiomers of citalopram on the single molecule level. This approach is based on force spectroscopy, which allows for the extraction of dynamic information under physiological conditions thus inaccessible via X‐ray crystallography. Two distinct populations of characteristic binding strengths of citalopram to SERT were revealed in Na⁺‐containing buffer. In contrast, in Li⁺‐containing buffer, SERT showed only low force interactions. Conversely, the vestibular mutant SERT‐G402H merely displayed the high force population. These observations provide physical evidence for the existence of two binding sites in SERT when accessed in a physiological context. Competition experiments revealed that these two sites are allosterically coupled and exert reciprocal modulation.