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1.
The one-pot reaction of 1-tetralone with nitriles in the presence of triflic anhydride affords in good yields 2,4-disubstituted 5,6-dihydrobenzo[h]quinazolines, which oxidation with DDQ leads to the corresponding benzo[h]quinazolines. 2-Tetralone undergoes identical process forming 1,3-disubstituted 5,6-dihydrobenzo[f]quinazolines. However, when the reaction of 2-tetralone is carried out with methylthiocyanate as nitrile, 5-methylthiotetrahydrodibenzo[a,i]phenanthridines are isolated in good yields. Easy transformations of the methylthio group offer possible access to a variety of substituted dibenzo[a,i]phenanthridines. 相似文献
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Martinez Alvarez R Herrera Fernandez A Chioua M Ramiro Perez P Villalba Vilchez N Guzman Torres F 《Rapid communications in mass spectrometry : RCM》1999,13(24):2480-2488
Several 5,6-dialkyl-2,4-diarylpyrimidines were prepared and their electron ionization (EI) mass spectra reported. The benzylic cleavage takes place easily together with an important McLafferty rearrangement. The involvement of the nitrogen atom appears to be important in the fragmentation of 5-methyl-substituted pyrimidines. In contrast, the 6-methyl-substituted pyrimidines undergo benzylic cleavage without hydrogen transfer. Thus, the difference in the mass spectrometric behaviour allows the identification of these isomeric compounds which, in contrast, exhibit only small differences in their NMR spectra. Copyright 1999 John Wiley & Sons, Ltd. 相似文献
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Vincent T’kindt Karima Bouibede-Hocine Carl Esswein 《4OR: A Quarterly Journal of Operations Research》2005,3(1):1-21
In this paper we tackle an important point of combinatorial optimisation: that of complexity theory when dealing with the counting or enumeration of optimal solutions. Complexity theory has been initially designed for decision problems and evolved over the years, for instance, to tackle particular features in optimisation problems. It has also evolved, more or less recently, towards the complexity of counting and enumeration problems and several complexity classes, which we review in this paper, have emerged in the literature. This kind of problems makes sense, notably, in the case of multicriteria optimisation where the aim is often to enumerate the set of the so-called Pareto optima. In the second part of this paper we review the complexity of multicriteria scheduling problems in the light of the previous complexity results.Received: November 2004 / Received version: March 2005MSC classification:
90B40, 90C29, 68Q15 相似文献
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Antonio Herrera Nazario Martín Rachid Chioua Ángel Sánchez-Vázquez John Almy 《Tetrahedron》2009,65(8):1697-2715
Two alternative methods for the preparation of new pyrimidine Diels-Alder cycloadducts from the readily available 2,4-bis(methylsulfanyl)-5,6-dihydrocyclobuta[d]pyrimidine are presented. In the first method, the in situ generated pyrimidine ortho-quinodimethane reacts with various dienophiles to form the respective cycloadducts bearing two methylthio groups, which can be easily replaced by other functional groups. In the second method, one or both of the methylsulfanyl groups of the starting pyrimidine are replaced first and the resulting functionalized pyrimidines are able to undergo Diels-Alder cyclization with different dienophiles to form pyrimidine cycloadducts. These alternative synthetic strategies provide access to a wide variety of pyrimidine cycloadducts with a different substitution pattern on the pyrimidine ring. Yield data indicate that the electronic nature of the functional groups strongly influence the efficiency of the cycloaddition reaction. 相似文献
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Synthesis of 5‐Amino‐3,3‐dimethyl‐7‐phenyl‐3H‐[1,2]oxathiolo[4,3‐b]pyridine‐6‐carbonitrile 1,1‐Dioxides
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Mourad Chioua Abdelouahid Samadi Denis Postel Jan Balzarini José Marco‐Contelles 《Journal of heterocyclic chemistry》2014,51(5):1452-1456
The reaction of 4‐amino‐5,5‐dimethyl‐5H‐1,2‐oxathiole 2,2‐dioxide ( 1 ) with 2‐(arylidene)malononitriles 2 in ethanol, at reflux, using piperidine as catalyst, afforded 5‐amino‐3,3‐dimethyl‐7‐aryl‐3H‐[1,2]oxathiolo[4,3‐b]pyridine‐6‐carbonitrile 1,1‐dioxides ( 3 ) in moderate chemical yields. 相似文献
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Acid-promoted asymmetric sulfoxidations of prochiral sulfides using binaphthyl-derived oxaziridines have been studied. The reactions of dialkyl or aryl-alkyl sulfides gave good yields of the corresponding sulfoxides with enantiopurities ranging from 20% to 80%. The influence of temperature and strength of the acid catalyst on enantioselectivity was studied. The absolute configuration of the resulting major enantiomer varied with the structure of the sulfide. 相似文献
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This work is concerned with the existence of unbounded positive solutions for a second-order nonlinear three-point boundary
value problem on the positive half-line. The interesting points of the results are that the nonlinearity depends on the solution
and its derivative and may change sign. Moreover, it satisfies general polynomial growth conditions. New existence results
of nontrivial single and multiple positive solutions are proved using recent fixed point theorems on cones in a special Banach
space. 相似文献
10.
This paper studies pricing strategies in a market channel composed of one national brand manufacturer and two retailers who, each, carry their own store brand and a national brand products. The model accounts for product competition between store brands and the national brand products, as well as for store competition between retailers. 相似文献