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Kadirappa Aggile Manikandan Alagumuthu Pramod Kumar Ayyakannu Arumugam Napoleon 《Journal of heterocyclic chemistry》2020,57(3):1403-1413
A simple, efficient, and straightforward one-pot three-component synthesis of functionalized tetrahydropyrans ( 6a-l ) is carried-out in the presence of an inexpensive and environmentally benign Eaton's reagent as a catalyst to discover some ACE inhibitors and anti-inflammatory agents. Angiotensin-converting enzyme (ACE) is highly involved in the renin-angiotensin system and often directly associated with cardiovascular dysfunction via inflammation. Thus, the cardiovascular protective effect of newly synthesized tetrahydropyrans ( 6a-l ) was evaluated through ACE inhibition, human red blood cell (HRBC) membrane stabilization, and molecular docking studies. As the results complied, compounds 6e and 6f were identified as effective ACE inhibitors. Docking studies, HRBC based anti-inflammatory assay, and SAR studies revealed that compounds 6e and 6f could be good anti-inflammatory agents apart from ACE inhibitors. 相似文献
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Kumar Neeraj Devineni Subba Rao Aggile Kadirappa Gajjala Prasad Reddy Kumar Pramod Dubey Shailendra Kumar 《Research on Chemical Intermediates》2018,44(1):567-584
Research on Chemical Intermediates - The present study is related to a commercially practicable new synthetic process for production of teneligliptin hydrobromide hydrate (1), a dipeptidyl... 相似文献
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