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1.
Taisei Ueda Masumi Asahi Shin-Ichi Nagai Jinsaku Sakakibara 《Journal of heterocyclic chemistry》1996,33(1):169-172
Diazepinoquinoxalines 3, 4 and imidazolobenzopteridines 5, 6a-d, 7a-d, 8, 9 were synthesized from 3-allylamino-6,7-dimethyl-2-quinoxalinecarboxamide ( 1 ) and 2-allylamino-6,7-dimethyl-3,4-dihydrobenzo[g]pteridin-4-one ( 2 ) by the intramolecular cyclization using phenylselenenyl chloride. 相似文献
2.
Sbin-Ichi Nagai Taisei Ueda Akito Nagatsu Keiko Nakaoka Nobutoshi Murakami Jinsaku Sakakibara Michiko Fujita Yoshihiro Hotta 《Journal of heterocyclic chemistry》1998,35(2):329-332
5,8-Methanoquinazolines fused with imidazoles 4a-4b , thiadiazoles 5–6 , pyrimidines 7, 9, 11 and 12 , and 1,3,5-triazine 13 were prepared starting from (5R,8S)-2-amino-8,9,9-trimethyl-5,6,7,8-tetrahydro-5,8-methanoquinazoline 3 . Most compounds possessed central nervous system stimulant activities. 相似文献
3.
Taisei Ueda Tsuneyasu Adachi Shin-Ichi Nagai Jinsaku Sakakibara Mitsuo Murata 《Journal of heterocyclic chemistry》1988,25(3):791-794
[1,2,4]Triazino[3,2-f]purines 3a-e and [1,2,4]triazepino[3,2-f]purine 5 were synthesized by the reaction of 7,8-diamino-1,3-dimethylxanthine 1 with diketones such as glyoxal, diacetyl, dibenzoyl, pyruvic aldehyde dimethyl acetal, phenylglyoxal or acetylacetone in acetic acid in the presence of boric acid or polyphosphoric acid. 相似文献
4.
Shin-Ichi Nagai Taisei Ueda Masatoshi Takamura Akito Nagatsu Nobutoshi Murakami Jinsaku Sakakibara 《Journal of heterocyclic chemistry》1998,35(2):293-296
Novel camphor-1,2,4-triazines fused with imidazole 2–3 , thiadiazole 4 , 1,2,4-triazole 7 , pyrimidine 9–13 and 1,3,5-triazine 14 , were synthesized starting from (5R,8S)-3-amino-5,9,9-trimethyl-5,6,7,8-tetrahydro-5,8-methano-1,2,4-benzotriazine 1 . Evaluation of central nervous system stimulant activity demonstrated that the presence of a N-N group at C-3 position of 1,2,4-benzotriazine will be essential for the activity. 相似文献
5.
Taisei Ueda Naoyoshi Yatsuzuka Shin‐Ichi Nagai Kumiko Okada Emi Takeichi Hiromi Segi Jinsaku Sakakibara 《Journal of heterocyclic chemistry》2001,38(1):141-145
Oxidation of 7,8‐diaminotheophylline (1) with lead tetraacetate in refluxing toluene gave a mixture of 3‐amino‐5,7‐dimethylpyrimido[4,5‐e][1,2,4]triazine‐6,8‐dione ( 2 ) and 6‐cyanoimino‐5‐diazo‐1,3‐dimethylpyrimidine‐2,4‐dione ( 4 ). The latter was transformed to 2 by the reaction with 1‐propanethiol in quantitative yield. The reaction of 4 with methanol, ethanol and 1‐propanol in the presence of rhodium ( II ) acetate gave 5‐alkoxy‐6‐(2‐alkyl‐3‐isoureido)‐1,3‐dimethylpyrimidine‐2,4‐diones ( 7a‐c ). A similar reaction of 4 with alkylamines such as n‐propylamine, n‐butylamine, isobutylamine and n‐hexylamine gave a mixture of 7‐alkyl‐8‐aminotheophyllines ( 8a‐d ) and (5‐alkylamino‐1,3‐dimethyl‐2,4‐dioxopyrimidin‐6‐yl)cyanamides ( 9a‐d ). 相似文献
6.
Taisei Ueda Kenji Nakaya Shin-Ichi Nagai Jinsaku Sakakibara 《Journal of heterocyclic chemistry》1989,26(1):33-37
O-Alkylations of pyridoxine 1 and pyridoxamine 5 were carried out in acetone in the presence of sodium ethoxide and potassium iodide to give 5-alkoxy-6-methyl-3,4-(bishydroxymethyl)pyridines 2a-j and 5-alkoxy-4-aminomethyl-6-methyl-3-hydroxyrnethylpyridines 6a-e . 相似文献
7.
Nagatsu A Sugitani T Mori Y Okuyama H Sakakibara J Mizukami H 《Natural product research》2004,18(3):231-239
A simple but novel compound, S-1-methoxy-1-(3,5-dimethoxy-4-hydroxyphenyl)ethane, was isolated as a moderately antioxidative compound from rape (Brassica campestris L. subsp. napus) oil cake together with 5 known compounds. Three of these compounds, indolacetonitrile, 4-hydroxyindolacetonitrile, and 4-hydroxyphenylacetonitrile, showed strong antioxidative activity evaluated by the ferric thiocyanate method. 相似文献
8.
Nobuyuki Mizuno Kenji Esaki Jinsaku Sakakibara Nobutoshi Murakami Shinichi Nagai 《Photochemistry and photobiology》1991,54(5):697-701
The chemical structure of the 8-methoxypsoralen oxidized product that inhibits the chemotactic activity of anaphylatoxin C5a was determined to be 2,3-dihydro-2,9-dimethoxy-3-hydroxy-7-oxo-7H-furo[3,2-g] [1]benzopyran. Its minimal concentration required to obtain the maximum inhibition of C5a des Arg (1 x 10(-8) M) chemotactic activity is 2.5 x 10(-8) M. Bioactivity of this substance was maintained for 2 weeks, stored in a dark room at room temperature under aerobic conditions. There is a possibility that this substance may be useful in the treatment of immune complex diseases. 相似文献
9.
Shin-Icbi Nagai Taisei Ueda Satoe Sugiura Akito Nagatsu Nobutoshi Murakami Jinsaku Sakakibara Michiko Fujita Yoshiki Hotta 《Journal of heterocyclic chemistry》1998,35(2):325-327
5,8-Methanoquinazolines fused with 1,2,4-triazole 4–5 , tetrazole 6 , and 1,2,4-triazine 8 were prepared starting from 2-hydrazino-5,8-methanoquinazoline 3 . Compound 3 and 6 showed the most potent central nervous system (CNS) stimulant activities. 相似文献
10.
Toyo Kaiya Naohiro Shirai Jinsaku Sakakibara Yoichi Iitaka 《Tetrahedron letters》1979,20(44):4297-4298
Reaction of grayanotoxin-II (1) with thallium nitrate gave 3(S), 20-epoxy-6 (S), 14 (R), 16 (R)-trihydroxy-5-oxo-5, 10-seco-ent-kaur-1 (10) -ene (2). The structure of 2 was elucidated by the X-ray diffraction analysis of its reduction product (3). 相似文献