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Hong-Jian Ji Jia-Yuan Li Shi-Fei Wu Wen-Yong Wu Chang-Liang Yao Shuai Yao Jian-Qing Zhang De-An Guo 《Molecules (Basel, Switzerland)》2021,26(1)
Twelve compounds, including two new aristolochic acid analogues with a formyloxy moiety (9–10) and 10 known aristolochic acid derivates (1–8 and 11–12), were obtained from the roots of Aristolochia contorta. Their structures were elucidated using extensive spectroscopic methods. Their cytotoxic activity in human proximal tubular cells HK-2 was evaluated by the MTT method, which has been widely used to assess cell viability. Among these molecules, compounds 3 and 9 were found to be more cytotoxic. Furthermore, molecular modeling was used to evaluate, for the first time, the interactions of compounds 3 and 9 with the target protein organic anionic transporter 1 (OAT1) that plays a key role in mediating aristolochic acid nephropathy. Structure–activity relationships are briefly discussed. 相似文献
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Systematic study on the electronic/geometrical structures and the parity alternation effect of silicon-doped ternary cationic clusters HCnSi2+(n = 1 ~9) have been carried out at the coupled cluster level. The ground-state (G-S) isomers of the clusters have been defined. The C, chains of the G-S isomers display polyacetylene-like structures. The even-n cations are more stable than the odd-n ones. Such a trend of even/odd alternation has been elaborated based on concepts of the bond character, atomic charge, incremental binding energy, ionization potential, proton affinity and fragmentation energies of the systems. The findings accord with the relative intensities of HC,,Si2+ species recorded in the related mass spectrometric experiments. 相似文献
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吡啶酰胺基配体与Mn~(2 )、Fe~(3 )、Ru~(3 )配合物的合成和催化环己烯的氧化反应 总被引:4,自引:0,他引:4
由于吡啶环较一般芳环更稳定,抗氧化能力强,且毗院环上氮的孤电子对与中心金属的d轨道通过配位作用可组成更大的共轭体系,增强了中心金属与配体之间电子云的流动性,从而可调节金属配合物与氧形成超氧、过氧或单氧活性物种的电子云分布(包括电荷分布),进而影响其催化活性和选择性U,’1。根据这一构想,本文合成了含毗院酚胺基配体的金属Mn,Fe,Ru的配合物,在纯氧作氧源下,考察了它们催化环己烯氧化反应的性能。1催化剂的制备称取20mmolZ一毗陡甲酸溶于sml毗院中,10mmoll,2一乙M胺(或1,个丁M胺… 相似文献
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配合物1由醋酸镉和Nahca(对羟基肉桂酸钠)在水溶液中反应得到,配合物2由醋酸铜,Hhca和phen在水和乙醇混合溶液中反应得到。配合物1属正交晶系,Pbcn空间群。配合物2属单斜晶系,C2/c空间群。配合物1和2中配体中的羧酸根与金属离子都是螯合配位的,末端羟基没有参与配位。配合物1和2的结构中都包含了丰富的氢键。通过氢键作用,配合物1形成了三维网状超分子结构,配合物2形成了二维层状超分子结构。 相似文献
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配位化合物[Cd(hca)2(H2O)3](H2O)2,[Cu(hca)2(phen)]的合成与表征 总被引:1,自引:0,他引:1
配合物1由醋酸镉和Nahca(对羟基肉桂酸钠)在水溶液中反应得到,配合物2由醋酸铜,Hhca和phen在水和乙醇混合溶液中反应得到.配合物1属正交晶系,Pbcn空间群.配合物2属单斜晶系,C2/c空间群.配合物1和2中配体中的羧酸根与金属离子都是螯合配位的,末端羟基没有参与配位.配合物1和2的结构中都包含了丰富的氢键.通过氢键作用,配合物1形成了三维网状超分子结构,配合物2形成了二维层状超分子结构. 相似文献
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5-(p-氨基)-苄叉若丹宁光度法测定钯 总被引:4,自引:1,他引:3
在 ( 1 + 1 0 )的盐酸介质中 ,Triton X- 1 0 0存在下 ,钯与新试剂 5 - ( p-氨基 )苄叉若丹宁 ( ABR)形成红色配合物的显色反应 ,建立了测定微量钯的高灵敏光度分析法。配合物的λmax=475 nm,ε=9.35 4× 1 0 4 L·mol- 1· cm- 1 ,配合物中 Pd( )与 ABR的组成比为 1∶ 2 ,在 0 - 1 8μg Pd( ) / 2 5 m L 范围内符合比耳定律。方法用于金宝山 -锍合金中微量钯的测定 ,结果满意。 相似文献
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A new reagent 4-(H-acidazo)-l-phenyl-3-methylpyazolone(HPMP) has been synthesized and it color reaction with thorium(Ⅳ) was studied. In the presence of pH=4.6 HAc-NaAc buffer solution and CPB medium. HPMP can reacts with Th(Ⅳ) to form a 2:1 complex. The maximum absorption is at 555nm with molar absorptivity of 2.44×105L.mol-1.cm-1. This method can be applied to the determination of thorium in ores with satisfactory results. 相似文献