Characterization of UMD Banach Spaces by Imaginary Powers of Hermite and Laguerre Operators

In this paper we characterize the Banach spaces with the UMD property by means of L ^p -boundedness properties for the imaginary powers of the Hermite and Laguerre operators. In order to do this we need to obtain pointwise representations for the Laplace transform type multipliers associated with Hermite and Laguerre operators.     

Spaceborne laser filamentation for atmospheric remote sensing

A proof‐of‐concept of space‐borne laser filamentation for atmospheric remote sensing is presented. The remote generation of laser filaments from an Earth‐orbiting satellite is shown by numerical simulations to be theoretically possible for a large range of laser parameters. The model includes a realistic representation of the stratified atmosphere and accounts for multi‐species ionization and the dependence of air density upon the molecule type and altitude profile. The remote generation of a white light continuum extending from 350 nm to 1.1 μm within the filament is demonstrated, and hereby proposed as an atmospheric in‐situ light source for monitoring greenhouse gases and pollutants on a global scale by light detection and ranging (lidar) techniques. Scaling laws are also derived for estimating the filament altitude as a function of peak pulse power (3 GW‐3 TW), beam radii (10‐200 cm) and for three different curvatures (300, 390, 500 km) for femtosecond infrared (800 nm) pulses. We find that operating conditions for remote supercontinuum generation are already available with current ground‐based mobile laser technology and within reach of future space laser systems.

     

Chiral bromine–lithium exchange catalyzed by diamines

Different classes of prochiral polyhalide compounds have been tested in a chiral bromine–lithium exchange in the presence of different diamines with enantiomeric excesses of up to 63%.     

Beitrag zur Kinetik der Korrosion von Eisen in konzentrierter Schwefelsäure

Ohne Zusammenfassung     

Essential oil composition of the different parts of Eryngium bourgatii Gouan from Spain

The essential oil extracted from the different parts of Eryngium bourgatii Gouan: stems + leaves (E.b.SL), inflorescences (E.b.I) and roots (E.b.R), have been extracted by steam distillation and analysed by gas chromatography (GC) and gas chromatography coupled to mass spectrometry (GC-MS). Quantitative but not qualitative differences have been found between the analysed parts. The principal compounds from the inflorescences oil were found to be phyllocladene (37.6%) and bicyclogermacrene (15.1%), while the oil from stems and leaves showed phyllocladene (20.4%), gamma-muurolene (11.8%) and (E)-caryophyllene (10.1%) as main ones. The oil from the roots presented gamma-muurolene (15.4%) and phyllocladene (15.0%) as major constituents. It is worth mentioning the presence of a diterpene, phyllocladene, as main compound of the essential oil. This is the first report on the essential oil of this species.     

Raman comparison of skin dermis of different ages: focus on spectral markers of collagen hydration

Skin aging is the most visible sign of aging of the body. This complex process involves molecular and structural alterations of the main skin constituents. The major cutaneous constituent is type I collagen that gives strength and resilience to the skin. This macromolecule possesses a particular triple helix structure and is arranged in the form of a fibrous network. Water plays a crucial role for maintaining this molecular assembly which is altered during intrinsic chronological aging. To investigate some of these structural alterations, Raman microspectroscopy was employed since this biophotonic approach permits to probe the biomolecular composition of the skin in a non‐destructive manner. In addition, type I collagen gives specific Raman vibrations; some of which being sensitive to the molecule conformation and to the water environment. In this purpose, Raman spectra of four skin samples of different ages (two samples of 40 year old and two samples of 70 year old) were collected by varying the relative environmental humidity. Our experiments highlighted spectral differences between the four samples. The analysis of the Raman data permitted to suggest a model for the interactions between collagen and water molecules and a decrease in collagen fibers compactness with chronological aging. Our study demonstrates that Raman spectroscopy can be a useful tool to investigate skin aging, with innovative applications in dermatology as well as in cosmetics. Copyright © 2013 John Wiley & Sons, Ltd.     

Saffron and Its Major Ingredients’ Effect on Colon Cancer Cells with Mismatch Repair Deficiency and Microsatellite Instability

Background: Colorectal cancer (CRC) is one of the most common cancers worldwide. One of its subtypes is associated with defective mismatch repair (dMMR) genes. Saffron has many potentially protective roles against colon malignancy. However, these roles in the context of dMMR tumors have not been explored. In this study, we aimed to investigate the effects of saffron and its constituents in CRC cell lines with dMMR. Methods: Saffron crude extracts and specific compounds (safranal and crocin) were used in the human colorectal cancer cell lines HCT116, HCT116+3 (inserted MLH1), HCT116+5 (inserted MSH3), and HCT116+3+5 (inserted MLH1 and MSH3). CDC25b, p-H2AX, TPDP1, and GAPDH were analyzed by Western blot. Proliferation and cytotoxicity were analyzed by MTT. The scratch wound assay was also performed. Results: Saffron crude extracts restricted (up to 70%) the proliferation in colon cells with deficient MMR (HCT116) compared to proficient MMR. The wound healing assay indicates that deficient MMR cells are doing better (up to 90%) than proficient MMR cells when treated with saffron. CDC25b and TDP1 downregulated (up to 20-fold) in proficient MMR cells compared to deficient MMR cells, while p.H2AX was significantly upregulated in both cell types, particularly at >10 mg/mL saffron in a concentration-dependent manner. The reduction in cellular proliferation was accompanied with upregulation of caspase 3 and 7. The major active saffron compounds, safranal and crocin reproduced most of the saffron crude extracts’ effects. Conclusions: Saffron’s anti-proliferative effect is significant in cells with deficient MMR. This novel effect may have therapeutic implications and benefits for MSI CRC patients who are generally not recommended for the 5-fluorouracil-based treatment.