Levels in179W studied in the181Ta(p, 3n) reaction by on-line electron and gamma ray spectroscopy

Levels in¹⁷⁹W have been deduced from in-beam gamma and conversion electron studies of the¹⁸¹Ta(p, 3n)¹⁷⁹W reaction. The gamma-ray spectrum was studied with Ge(Li) detectors and a crystal diffraction spectrometer; the conversion electrons were measured with a broad range transport solenoid Si(Li) spectrometer. The multipolarities of some 50 transitions could be determined. Coriolis mixing of the Nilsson orbits withN=6 was calculated.     

A weight-function approach for determining watershed initial conditions for combustion waves

In many generic combustion models, one finds that a combustionwave will develop with a specific wave speed. However, thereare possible initial temperature profiles which do not evolveinto such waves, but rather die out to the ambient temperature.There can exist, in some models, a clear distinction betweenthose initial conditions that do evolve into combustion wavesand those that do not; this is sometimes referred to as thewatershed initial condition. When fuel consumption is consideredto be negligible, analytical methods can be used to obtain theexact watershed. In this paper, we consider the problem of determiningpseudo-watersheds and ascertaining the relationship betweenthese pseudo-watersheds and the exact watersheds. In the processa novel weight-function approach for infinite spatial domainsis developed.     

Direct visualization of bactericidal action of cationic conjugated polyelectrolytes and oligomers

The bactericidal mechanisms of poly(phenylene ethynylene) (PPE)-based cationic conjugated polyelectrolytes (CPE) and oligo-phenylene ethynylenes (OPE) were investigated using electron/optical microscopy and small-angle X-ray scattering (SAXS). The ultrastructural analysis shows that polymeric PPE-Th can significantly remodel the bacterial outer membrane and/or the peptidoglycan layer, followed by the possible collapse of the bacterial cytoplasm membrane. In contrast, oligomeric end-only OPE (EO-OPE) possesses potent bacteriolysis activity, which efficiently disintegrates the bacterial cytoplasm membrane and induces the release of bacterial cell content. Using single giant vesicles and SAXS, we demonstrated that the membrane perturbation mechanism of EO-OPE against model bacterial membranes results from a 3D membrane phase transition or perturbation.     

Comparison of methods for calculating the shock hugoniot of mixtures

Various methods used to determine the shock Hugoniot of condensed phase multi-component mixtures are reviewed and compared to available experimental data. The assumptions inherent in the different models are presented in this overview and their implications are discussed. The comparisons of the various models demonstrate that the predicted shock Hugoniots are in good agreement with published data despite the simplifying assumptions that are associated with the models. Averaging models are shown to be among the simplest methods to implement and result in the closest agreement with experimental data.     

Grafting Studies on Cotton Cellulose

Graft copolymerization reactions of vinyl monomers with fibrous cotton cellulose that were initiated at free-radical sites formed on the cellulose molecule are discussed. The effects of experimental conditions on the methods of initiating these free-radical reactions and on the location of these sites on the cellulose molecule are outlined. Some of the properties of the fibrous cellulose graft copolymers are discussed.     

Synthesis of cytotoxic cyanobactin,Wewakazole B

We report herein the synthesis of cytotoxic cyanobactin, Wewakazole B through an efficient solution-phase approach. The key steps of the synthesis are the macrocyclic lactamization of linear dodecapeptide and construction of two hexapeptides with three different substituted oxazole rings.     

Electron spin resonance studies of propagating radicals in polymerization. I. Methacrylate propagating radicals

Ferric chloride-photosensitized free-radical initiation was used to generate propagating radicals in polymerization of methacrylic acid (MAA), allyl methacrylate (AMA), methyl methacrylate (MMA), 1,3-butylene dimethacrylate (1,3-BDMA), hydroxypropyl methacrylate (HPMA), lauryl methacrylate (LMA), hexyl methacrylate (HMA), and methacrylamide (MA) in rigid glasses of methanol or acetone at near liquid nitrogen temperatures. The formation and conformational changes of these propagating radicals at different temperatures were studied by electron spin resonance (ESR) spectroscopy. When methanol was the rigid glass, ·CH₂OH radicals were formed initially and were stable below ?160°C. As the temperature of the rigid glass was increased, the ·CH₂OH radicals reacted with monomer to yield propagating radicals. With the exception of the propagating radical for methacrylamide, the propagating radicals of the methacrylates examined initially generated five-line ESR spectra which gradually changed to nine-line spectra, as temperature of the rigid glass was increased. It was concluded that one type of propagating radical was formed in all cases. However, when the temperature of the rigid glass was increased, the single structural conformation that initially allowed one of the methylene hydrogens and methyl group to interact with the unpaired electron to generate only a five-line spectrum was changed to yield a second conformation that allowed interaction to generate an additional four-line spectrum. Finally, a mixture of the propagating radical for methacrylate monomer in two structural conformations was obtained, and an ESR spectrum consisting of nine lines (5 + 4 lines) was generated. In the case of the propagating radical for methacrylamide this change to yield two structural conformations evidently was hindered, so that only an ESR spectrum consisting of five lines was generated.     

A Unified Approach to Couple Aromatic Heteronucleophiles to Azines and Pharmaceuticals

Coupling aromatic heteronucleophiles to arenes is a common way to assemble drug‐like molecules. Many methods operate via nucleophiles intercepting organometallic intermediates, via Pd‐, Cu‐, and Ni‐catalysis, that facilitate carbon‐heteroatom bond formation and a variety of protocols. We present an alternative, unified strategy where phosphonium salts can replicate the behavior of organometallic intermediates. Under a narrow set of reaction conditions, a variety of aromatic heteronucleophile classes can be coupled to pyridines and diazines that are often problematic in metal‐catalyzed couplings, such as where (pseudo)halide precursors are unavailable in complex structures with multiple polar functional groups.     

Blast wave attenuation through a composite of varying layer distribution

The interaction of a blast wave with a multi-layered material is investigated for the purpose of blast wave attenuation. For a fixed total mass and thickness of material, the effect of layering of the materials in the system on shock wave transmission is considered based on theoretical and experimental results. The system of materials is a discrete set of steel and low density foam plates of varying thicknesses. A wave tracking algorithm is employed to predict the behavior of the system with respect to simple wave interactions assuming elastic materials. The theoretical results are used to identify the change in wave dynamics caused by altering the distribution of the material layers. It has been shown that the time scale corresponding to stress equilibration across the high-low impedance material interfaces in the system dominates the behavior of the system and that the stress transfer is limited by the low impedance material.     

Magnetic resonance imaging of the chest: A diagnostic comparison with computed tomography and hilar tomography

Computed tomography (with and without contrast enhancement) provides excellent diagnostic accuracy for the evaluation of the chest. Oblique (55°) and anteroposterior hilar tomography is accurate for the evaluation of hilar nodes and masses. Magnetic resonance techniques provide excellent differentiation of vascular and nonvascular structures and therefore should be useful in the hilum and mediastinum. Magnetic resonance imaging was used in 55 patients with known pathologic conditions in the mediastinum, hilum, and lungs to determine the accuracy and efficacy of this technique compared with computed and hilar tomography. The pathologic conditions included primary and metastatic neoplasms, benign masses, vascular abnormalities, and pulmonary nodules and infiltrates. Spatial resolution with magnetic resonance imaging is less than with computed tomography with our instrument (0.15 T resistive magnet). However, in the hilum and mediastinum, magnetic resonance imaging provided diagnostic information equal to that of computed tomography with contrast in 90% of patients. Vascular and nonvascular structures were more easily differentiated than with hilar tomography. Computed tomography was far superior in the evaluation of multiple pulmonary nodules. Lesions of the chest wall were better seen with magnetic resonance imaging because of the improved soft tissue contrast.