A Geometric characterization of the perfect Suzuki-Tits ovoids

We characterize in a geometrical way those Suzuki-Tits ovoids which are defined over a perfect fieidK (or equivalently living inside a self polar symplectic quadrangle). We simplify our axioms in the particular cases that (1) the associated Suzuki group has exactly two orbits in the set of lines ofPG(3,K), and (2) the ovoid is finite.Senior Research Associate at the Belgian National Fund for Scientific Research     

Conformational analysis of dipeptide‐derived polyisocyanides

The conformational properties of polymers derived from isocyanodipeptides have been investigated with a combination of model calculations, X‐ray diffraction, and circular dichroism spectroscopy. Depending on the configuration of the side chains, defined arrays of hydrogen bonds along the polymeric backbone are formed. This leads to a well‐defined conformation as, for example, expressed in the formation of lyotropic liquid‐crystalline phases and increased helical stability. Upon the disruption of the hydrogen bonds by a strong acid, a less well‐defined macromolecular conformation is observed. © 2003 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 41: 1725–1736, 2003     

General covariance of the non-abelian DBI-action: checks and balances

We perform three tests on our proposal to implement diffeomorphism invariance in the non-abelian D0-brane DBI action as a base-point independence constraint between matrix Riemann normal coordinate systems. First, we show that T-duality along an isometry correctly interchanges the potential and kinetic terms in the action. Second, we show that the method to impose base-point independence using an auxiliary dN²-dimensional nonlinear sigma model also works for metrics which are curved along the brane, provided a physical gauge choice is made at the end. Third, we show that without alteration this method is applicable to higher order in velocities. Testing specifically to order 4, we elucidate the range of validity of the symmetrized trace approximation to the non-abelian DBI action.     

Fluid-fluid phase separation in colloid-polymer mixtures studied with small angle light scattering and light microscopy

Mixtures of colloidal silica spheres and polydimethylsiloxane in cyclohexane with a colloid-polymer size ratio of about one were found to phase separate into two fluid phases, one which is colloid-rich and one which is colloid-poor. In this work the phase separation kinetics of this fluid-fluid phase separation is studied for different compositions of the colloid-polymer mixtures, and at several degrees of supersaturation, with small angle light scattering and with light microscopy. The small angle light scattering curve exhibits a peak that grows in intensity and that shifts to smaller wave vector with time. The characteristic length scale that is obtained from the scattering peak is of the order of a few μm, in agreement with observations by light microscopy. The domain size increases with time as , which might be an indication of coarsening by diffusion and coalescence, like in the case of binary liquid mixtures and polymer blends. For sufficiently low degrees of supersaturation the angular scattering intensity curves satisfy dynamical scaling behavior.     

Systems with outer constraints. Gupta-Bleuler electromagnetism as an algebraic field theory

Since there are some important systems which have constraints not contained in their field algebras, we develop here in aC*-context the algebraic structures of these. The constraints are defined as a groupG acting as outer automorphisms on the field algebra , :G Aut , _G Inn , and we find that the selection ofG-invariant states on is the same as the selection of states onM(G ) by (U _g)=1gG, whereU _g M (G )/ are the canonical elements implementing _g . These states are taken as the physical states, and this specifies the resulting algebraic structure of the physics inM(G ), and in particular the maximal constraint free physical algebra . A nontriviality condition is given for to exist, and we extend the notion of a crossed product to deal with a situation whereG is not locally compact. This is necessary to deal with the field theoretical aspect of the constraints. Next theC*-algebra of the CCR is employed to define the abstract algebraic structure of Gupta-Bleuler electromagnetism in the present framework. The indefinite inner product representation structure is obtained, and this puts Gupta-Bleuler electromagnetism on a rigorous footing. Finally, as a bonus, we find that the algebraic structures just set up, provide a blueprint for constructive quadratic algebraic field theory.     

Nanoscale organization of the pathogen receptor DC-SIGN mapped by single-molecule high-resolution fluorescence microscopy.

DC-SIGN, a C-type lectin exclusively expressed on dendritic cells (DCs), plays an important role in pathogen recognition by binding with high affinity to a large variety of microorganisms. Recent experimental evidence points to a direct relation between the function of DC-SIGN as a viral receptor and its spatial arrangement on the plasma membrane. We have investigated the nanoscale organization of fluorescently labeled DC-SIGN on intact isolated DCs by means of near-field scanning optical microscopy (NSOM) combined with single-molecule detection. Fluorescence spots of different intensity and size have been directly visualized by optical means with a spatial resolution of less than 100 nm. Intensity- and size-distribution histograms of the DC-SIGN fluorescent spots confirm that approximately 80 % of the receptors are organized in nanosized domains randomly distributed on the cell membrane. Intensity-size correlation analysis revealed remarkable heterogeneity in the molecular packing density of the domains. Furthermore, we have mapped the intermolecular organization within a dense cluster by means of sequential NSOM imaging combined with discrete single-molecule photobleaching. In this way we have determined the spatial coordinates of 13 different individual dyes, with a localization accuracy of 6 nm. Our experimental observations are all consistent with an arrangement of DC-SIGN designed to maximize its chances of binding to a wide range of microorganisms. Our data also illustrate the potential of NSOM as an ultrasensitive, high-resolution technique to probe nanometer-scale organization of molecules on the cell membrane.