A practical and green approach towards synthesis of new N-sulfonylimines under ultrasound irradiation

An efficient protocol was developed for the synthesis of N-sulfonylimines under environment friendly conditions. Ultrasonic energy was employed to obtain the desired products in excellent yields with high purity under solvent- and catalyst-free conditions. The synthesis of new N-sulfonylimines was accomplished from various N-sulfonamides and benzaldehyde.

The structures of the synthesized compounds are confirmed by elemental analysis as well as by ¹H, ¹³C NMR spectral data, IR and MS.     

Synthesis,antioxidant and anticholinesterase activities of novel quinoline-aminophosphonate derivatives

A series of 20 novel α-aminophosphonate derivatives bearing quinoline or quinolone moiety was designed and synthesized via Kabachnik-Fields reaction in the presence of triethylammonium acetate as a solvent and catalyst under ultrasound irradiation. This procedure affords products in high yields and short reaction times. Molecular structures of the synthesized compounds 4a-g and 5a-m were confirmed using various spectroscopic methods. The antioxidant activity of these compounds was evaluated by eight complementary in vitro tests. The anticholinesterase activity (AChE, BChE) of these compounds were also evaluated. In addition, theoretical calculations of all compounds were investigated as corrosion inhibitors using density functional theory (DFT). The results revealed that 16 of these compounds exhibited high levels of antioxidant activities depending on the assay and that most compounds showed more potent inhibitory activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).     

Fuzzy Optimality Conditions for Fractional Multiobjective Bilevel Problems Under Fractional Constraints

In this article, we are concerned with fractional multiobjective optimization problems. In order to derive optimality conditions, we consider a new single level problem [12 J.J. Ye ( 2006 ). Constraint qualification and KKT conditions for bilevel programming problems . Mathematics of Operations Research 31 : 811 – 824 .[Crossref], [Web of Science ®] , [Google Scholar]], which is locally equivalent to the bilevel fractional multiobjective problem (P) at the optimal solution. Our approach consists of using another approach initiated by Mordukhovich [7 B.S. Mordukhovich ( 1976 ). Maximum principle in problems of time optimal control with nonsmooth constraints . J. Appl. Math. Mech. 40 : 960 – 969 .[Crossref], [Web of Science ®] , [Google Scholar], 8 B.S. Mordukhovich ( 1980 ). Metric approximations and necessary optimality conditions for general classes of nonsmooth extremal problems . Soviet. Math. Dokl. 22 : 526 – 530 . [Google Scholar]], which does not involve any convex approximations and convex separation arguments, called the extremal principle [5 B.S. Mordukhovich ( 2006 ). Variational Analysis and Generalized Differentiation, I: Basic Theory . Grundlehren Series (Fundamental Principles of Mathematical Sciences) , Vol. 330 , Springer , Berlin . [Google Scholar], 6 B.S. Mordukhovich ( 2006 ). Variational Analysis and Generalized Differentiation, II: Applications , Grundlehren Series (Fundamental Principles of Mathematical Sciences) , Vol. 331 , Springer , Berlin . [Google Scholar], 9 B.S. Mordukhovich ( 1994 ). Generalized differential calculus for nonsmooth and set-valued mappings . J. Math. Anal. Appl. 183 : 250 – 288 .[Crossref], [Web of Science ®] , [Google Scholar]], for the study of necessary optimality conditions in fractional vector optimization.