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T Kai T Isami K Kobata Y Kurosaki T Nakayama T Kimura 《Chemical & pharmaceutical bulletin》1992,40(9):2498-2504
The maximum fluxes (Jmax) of beta-blockers through keratinized membranes were determined in vitro and compared with their physiochemical parameters such as lipophilicity (log k'0) and melting point (mp). Rat abdominal skin and hamster cheek pouch mucosa were used as the model membranes. Propranolol, metoprolol, timolol, pindolol, nadolol and agenolol were used as beta-blockers with a variety of physicochemical characters. Linear relations of Jmax with either log k'0 or mp were observed both in intact rat skin and in intact hamster cheek pouch, suggesting that the lipophilicity and thermodynamic activity of a drug in the crystal state primarily affect the drug's permeation through these membranes. However, the slope, dJmax/d(log k'0), for cheek pouch mucosa was greater than that for rat skin, corresponding to the lack of appendigeal shunt pathways in cheek pouch. Penetration studies using the delipidized membranes and the isolated stratum corneum sheet of hamster cheek pouch mucosa clarified that the primary rate-limiting barrier function might exist in the lipid layer of the stratum corneum. Jmax values for the tape-stripped and delipidized skins correlated with both the solubilities of drugs in the vehicle and with the mp, suggesting the polar porous characteristics of both model membranes. However, a theoretical approach confirmed that the contribution of an intracellular or aqueous pore route in the intact membrane to the permeation of drugs with positive lipophilic indexes is negligible. 相似文献
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Shigeru Maeda Akira Ohki Katsuhiro Kusadome Takayoshi Kuroiwa Isami Yoshifuku Kensuke Naka 《应用有机金属化学》1992,6(2):213-219
Accumulation, biomethylation and excretion of arsenic by an autotrophic freshwater alga, and the transport and transformation of the arsenic in the freshwater food chain [alga (autotroph)-moina (planktonic grazer) or shrimp (herbivore)-guppy (carnivore)] were investigated. These experimental results lead to the conclusion that total arsenic concentrations in organisms after accumulation from foods decreased one order of magnitude per elevation of the trophic level and biomethylation of the arsenic increased successively with an elevation in the trophic level. Predominant methylated arsenic species in moina and guppy were dimethyl- and trimethyl-arsenic compounds, respectively. Shrimp accumulated dimethyl- and trimethyl-arsenic compounds in nearly equivalent quantities. No or little monomethylarsenic compound was detected either in herbivores or carnivores. 相似文献
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Yoshifuku S Chen S McMahon EM Yoshikawa A Sengupta PP Korinek J Belohlavek M 《Ultrasonics》2007,46(2):109-118
Objectives
We introduced a harmonic-to-fundamental ratio (HFR) of the radiofrequency (RF) signals that reduces confounding effects of attenuation. We studied whether HFR analysis of RF signals received from contrast microbubbles allows accurate measurement of the left ventricular (LV) cavity area under varying levels of attenuation.Background
Attenuation is a fundamental problem in ultrasound imaging and limits the use of clinical echocardiography.Methods
RF data from short axis systolic and diastolic scans were obtained from 14 open-chest dogs following left-atrial bolus of Optison. Attenuation was induced by interposed silicone pads calibrated to induce 7 dB or 14 dB reductions of the backscattered RF signal. RF images were reconstructed from the RF signals, HFR values calculated for each image pixel for 0 dB, 7 dB and 14 dB attenuation conditions, and LV area obtained by summation of “LV cavity pixels”. A reference LV cavity area was obtained from endocardial border tracings in enhanced scans by experts.Results
Correlation of the HFR-defined and reference areas at systole was R = 0.95, R = 0.94, and R = 0.91 for 0 dB, 7 dB and 14 dB levels of attenuation, respectively, and at diastole was R = 0.95 for 0 dB, 7 dB and 14 dB levels of attenuation. The mean difference from both systolic and diastolic values was <1.45 cm2 (i.e. negligible) in all attenuation settings.Conclusion
Our novel HFR method supports precise measurement of the LV cavity area in contrast images with simulated high attenuation of ultrasound signals. 相似文献5.
Y. Fujita H. Fujita T. Adachi G.P.A. Berg E. Caurier H. Fujimura K. Hara K. Hatanaka Z. Janas J. Kamiya T. Kawabata K. Langanke G. Martınez-Pinedo T. Noro E. Roeckl Y. Shimbara T. Shinada S.Y. van der Werf M. Yoshifuku M. Yosoi R.G.T. Zegers 《The European Physical Journal A - Hadrons and Nuclei》2002,13(4):411-418
Under the assumption that isospin is a good quantum number, symmetry is expected for the transitions from the ground states
of T = 1, T
z = ±1 nuclei to the common excited states of the T
z = 0 nucleus situated between the two nuclei. The symmetry can be studied by comparing the strengths of Gamow-Teller (GT)
transitions obtained from a (p, n)-type charge-exchange reaction on a target nucleus with T
z = 1 with those from the β-decay of the T
z = - 1 nucleus. The A = 58 system is the heaviest for which such a comparison is possible. As a part of the symmetry study, we measured the GT
transitions from 58Ni (T
z = 1) to 58Cu (T
z = 0) by using the zero-degree (3
He, t) reaction at 150 MeV/nucleon. With the achieved resolution of 50 keV, many hitherto unresolved GT states have been identified.
The GT transition strengths were obtained for states up to 8 MeV excitation, i.e., near to the Q window limitation ( Q
EC = 9.37 MeV) of the β-decay from 58Zn (T
z = - 1) to 58Cu. The strength distribution is compared with that from shell-model calculations.
Received: 24 November 2001 / Accepted: 30 January 2002 相似文献
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Shigeru Maeda Saori Fujita Akira Ohki Isami Yoshifuku Shiro Higashi Toshio Takeshita 《应用有机金属化学》1988,2(4):353-357
Accumulation, biomethylation and excretion of arsenic by the arsenic-tolerant freshwater blue–green alga, Phormidium sp., which had been isolated from an arsenic-polluted environment, were investigated. The cellular growth curves were in fair agreement with a ‘logistic curve’ equation. The growth increased with an increase in the surrounding arsenic concentration up to 100 m?g g?1. The cells survived even at 7000 m?g g?1. The arsenic concentration of the cells increased with an increase of the surrounding arsenic concentration up to 7000 m?g g?1. Phosphorus concentrations in the medium affected the growth and arsenic accumulation. No arsenic was accumulated by cells killed by ethanol. The arsenic was methylated to the extent of 3.2% of the total arsenic accumulated. When the cells were transferred into an arsenic-free medium, 85% of the arsenic accumulated was excreted; 58% of the excreted arsenic was in methylated form implying extensive methylation in the arsenic-free medium. 相似文献
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Noboru Ono Hideyoshi Miyake Akio Kamimura Isami Hamamoto Rui Tamura Aritsune Kaji 《Tetrahedron》1985,41(19):4013-4023
Aliphatic nitro groups are replaced by hydrogen on treatment with tributyltin hydride which proceeds via free radical chain processes. As the nitro group is selectively denitrated and other reducible groups are not affected with tributyltin hydride, this reaction can be used as a method for removing the nitro group from polyfunctional compounds. The radical intermediates generated via denitration can be also used for the carbon-carbon bond forming reactions. 相似文献
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Thukaa Kouka Sachiko Akase Isami Sogabe Chunsheng Jin Niclas G. Karlsson Kiyoko F. Aoki-Kinoshita 《Molecules (Basel, Switzerland)》2022,27(6)
Glycan biosynthesis simulation research has progressed remarkably since 1997, when the first mathematical model for N-glycan biosynthesis was proposed. An O-glycan model has also been developed to predict O-glycan biosynthesis pathways in both forward and reverse directions. In this work, we started with a set of O-glycan profiles of CHO cells transiently transfected with various combinations of glycosyltransferases. The aim was to develop a model that encapsulated all the enzymes in the CHO transfected cell lines. Due to computational power restrictions, we were forced to focus on a smaller set of glycan profiles, where we were able to propose an optimized set of kinetics parameters for each enzyme in the model. Using this optimized model we showed that the abundance of more processed glycans could be simulated compared to observed abundance, while predicting the abundance of glycans earlier in the pathway was less accurate. The data generated show that for the accurate prediction of O-linked glycosylation, additional factors need to be incorporated into the model to better reflect the experimental conditions. 相似文献
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An ultra-precise method of joining optical lenses in a housing by a shrinkage fit has been developed using a shrink fitter, which is a cylindrically shaped machine element made of a plastic material. In this method, the form error of the shrink fitter increased the interference of shrinkage fit which caused a lens deformation much greater than the limitation of surface irregularity of λ/2. With an fθ lens unit of the laser scanner, this lens deformation may deteriorate the laser beam spots on an image plane. Therefore, the shrink fitter is carefully and precisely turned, however this takes time and costs money. This is a contact problem between the optical lenses and the shrink fitter. In this paper, to determine limit interferences of the shrink fitter, the effect of the interference of the shrinkage fit on the scanning performance was examined through computer simulation. 相似文献
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