Simultaneous determination of amoxycillin trihydrate and clavulanate potassium in pharmaceutical preparations by thin-layer chromatography/densitometry

A simple and rapid densitometric method has been developed for the simultaneous determination of amoxycillin trihydrate and clavulanate potassium in pharmaceutical preparations. After extraction of the analytes with distilled water, the extracts were spotted on precoated silica gel plates, which were then eluted with butyl acetate-methanol-glacial acetic acid-water (15 + 7.5 + 7.5 + 3, v/v). Quantitative evaluation was performed by measuring the absorbance reflectance of the analyte spots at lambda = 240 nm. The densitometric method is rapid, selective, precise, and accurate and, thus, can be used for routine analysis of pharmaceutical preparations in quality control laboratories of the pharmaceutical industry.     

Simultaneous Densitometric Determination of Hydrocortisone Acetate and 2-Phenoxyethanol in Creams

JPC – Journal of Planar Chromatography – Modern TLC - A simple and rapid TLC-densitometric method has been developed for simultaneously determination of hydrocortisone acetate and...     

Densitometric Determination of Taurine and l-Lysine Hydrochloride in an Energy Drink and in Multi-Vitamin Syrup,and Validation of the Method

JPC – Journal of Planar Chromatography – Modern TLC - A simple and rapid densitometric method has been developed for determination of taurine and lysine in ‘energy drinks’...     

TLC Determination of Clobetasol Propionate in Topical Preparations,and Validation of the Method

JPC – Journal of Planar Chromatography – Modern TLC -     

Densitometric Determination of Betamethasone Dipropionate and Salicylic Acid in Lotions,and Validation of the Method

JPC – Journal of Planar Chromatography – Modern TLC - A simple and rapid densitometric method has been developed for determination of betamethasone dipropionate and salicylic acid in...     

Densitometric Determination of Mebhydrolin Napadisylate in Tablets

JPC – Journal of Planar Chromatography – Modern TLC - A simple and rapid high-performance thin-layer chromatography (HPTLC) densitometric method has been developed for the determination...     

Lecythomycin, a new macrolactone glycoside from the endophytic fungus Lecythophora sp

A new macrolactone glycoside, lecythomycin (1), 23-methyl-3-(1-O-mannosyl)-oxacyclotetracosan-1-one, was isolated from the endophytic fungus Lecythophora sp. (code 30.1), an endopyte of the Indonesian plant Alyxia reinwardtii. The structure of 1 was elucidated on the basis of NMR spectroscopic and mass spectrometric data. The isolated compound displayed antifungal activity against strains of Aspergillus fumigatus and Candida kruzei at minimal inhibitory concentrations (MIC) of 62.5-125 microg/mL.     

Simultaneous determination of some active ingredients in cough and cold preparations by gas chromatography, and method validation

A simple and rapid gas chromatographic (GC) method has been developed for the simultaneous determination of combinations of acetaminophen, phenylpropanolamine hydrochloride, guaifenesin, pseudoephedrine hydrochloride, caffeine, chlorpheniramine maleate, and dextromethorphan hydrobromide in cough and cold tablets and syrups. After extraction of the analyte with alkaline ethyl acetate, 2 microL extract was injected (splitting ratio of 50:1) into a gas chromatograph equipped with a CBP1-M25-025 fused silica capillary column (25 m x 0.22 mm; film thickness, 0.25 microm). The column temperature was held at 150 degrees C for 5 min, increased to 175 degrees C at 3 degrees C/min, and increased to 270 degreesC at 10 degrees C/min. The temperatures of the flame ionization detector and injector were maintained at 300 degrees C. The GC method is inexpensive, rapid, accurate, and precise, and thus it can be used for routine analysis of tablet and syrup preparations in quality control laboratories of pharmaceutical companies.     

Cassiarins A and B, novel antiplasmodial alkaloids from Cassia siamea

Two novel alkaloids with an unprecedented tricyclic skeleton, cassiarins A (1) and B (2), have been isolated from the leaves of Cassia siamea, and the structures were elucidated on the basis of spectroscopic data. Cassiarin A (1) showed a potent antiplasmodial activity.     

Densitometric Determination of Desloratadine in Tablets,and Validation of the Method

JPC – Journal of Planar Chromatography – Modern TLC - A simple and rapid densitometric method has been developed for determination of desloratadine in tablets. After extraction of the...