The Multifaceted Role of Curcumin in Advanced Nanocurcumin Form in the Treatment and Management of Chronic Disorders

Curcumin is the primary polyphenol in turmeric’s curcuminoid class. It has a wide range of therapeutic applications, such as anti-inflammatory, antioxidant, antidiabetic, hepatoprotective, antibacterial, and anticancer effects against various cancers, but has poor solubility and low bioavailability. Objective: To improve curcumin’s bioavailability, plasma concentration, and cellular permeability processes. The nanocurcumin approach over curcumin has been proven appropriate for encapsulating or loading curcumin (nanocurcumin) to increase its therapeutic potential. Conclusion: Though incorporating curcumin into nanocurcumin form may be a viable method for overcoming its intrinsic limitations, and there are reasonable concerns regarding its toxicological safety once it enters biological pathways. This review article mainly highlights the therapeutic benefits of nanocurcumin over curcumin.     

Biharmonic extensions on trees without positive potentials

Let T be a tree rooted at e endowed with a nearest-neighbor transition probability that yields a recurrent random walk. We show that there exists a function K biharmonic off e whose Laplacian has potential theoretic importance and, in addition, has the following property: Any function f on T which is biharmonic outside a finite set has a representation, unique up to addition of a harmonic function, of the form f=βK+B+L, where β a constant, B is a biharmonic function on T, and L is a function, subject to certain normalization conditions, whose Laplacian is constant on all sectors sufficiently far from the root. We obtain a characterization of the functions biharmonic outside a finite set whose Laplacian has 0 flux similar to one that holds for a function biharmonic outside a compact set in Rn for n=2,3, and 4 proved by Bajunaid and Anandam. Moreover, we extend the definition of flux and, under certain restrictions on the tree, we characterize the functions biharmonic outside a finite set that have finite flux in this extended sense.     

Unusual product from the acid-catalyzed one-pot,multicomponent reaction of thiocarbohydrazide,aldehydes, and phenacyl bromides

A one-pot, three-component protocol for the synthesis of novel five-membered thiazole ring bonded to two hydrazone motifs is described. The acid-catalyzed reaction of one equivalent of thiocarbohydrazide, two equivalents of aromatic aldehydes, and one equivalent of phenacyl bromides afforded the five-membered thiazole ring. The reactions proceed with novel chemoselectivity. Similar reported protocols have always afforded 1,3,4-thiadiazines.     

Targeting Cytotoxin-Associated Antigen A,a Virulent Factor of Helicobacter pylori-Associated Gastric Cancer: Structure-Based In Silico Screening of Natural Compounds

Gastric cancer is the fifth most frequent cancer and the third major cause of mortality worldwide. Helicobacter pylori, a bacterial infection linked with GC, injects the cytotoxin-associated antigen A (CagA; an oncoprotein) into host cells. When the phosphorylated CagA protein enters the cell, it attaches to other cellular components, interfering with normal cellular signaling pathways. CagA plays an important role in the progression of GC by interacting with phosphatidylserine of the host cell membrane. Therefore, disrupting the CagA–phosphatidylserine connection using small molecules appears to be a promising therapeutic approach. In this report, we screened the natural compounds from ZINC database against the CagA protein using the bioinformatics tools. Hits were initially chosen based on their physicochemical, absorption, distribution, metabolism, excretion, and toxicity (ADMET) characteristics, as well as other drug-like characteristics. To locate safe and effective hits, the PAINS filter, binding affinities estimation, and interaction analysis were used. Three compounds with high binding affinity and specificity for the CagA binding pocket were discovered. The final hits, ZINC153731, ZINC69482055, and ZINC164387, were found to bind strongly with CagA protein, with binding energies of −11.53, −10.67, and −9.21 kcal/mol, respectively, which were higher than that of the control compound (−7.25 kcal/mol). Further, based on binding affinity and interaction pattern, two leads (ZINC153731, ZINC69482055) were chosen for molecular dynamics (MD) simulation analysis. MD results showed that they displayed stability in their vicinity at 100 ns. This study suggested that these compounds could be used as possible inhibitors of CagA protein in the fight against GC. However, additional benchwork tests are required to validate them as CagA protein inhibitors.     

Trees as Brelot spaces

A Brelot space is a connected, locally compact, noncompact Hausdorff space together with the choice of a sheaf of functions on this space which are called harmonic. We prove that by considering functions on a tree to be functions on the edges as well as on the vertices (instead of just on the vertices), a tree becomes a Brelot space. This leads to many results on the potential theory of trees. By restricting the functions just to the vertices, we obtain several new results on the potential theory of trees considered in the usual sense. We study trees whose nearest-neighbor transition probabilities are defined by both transient and recurrent random walks. Besides the usual case of harmonic functions on trees (the kernel of the Laplace operator), we also consider as “harmonic” the eigenfunctions of the Laplacian relative to a positive eigenvalue showing that these also yield a Brelot structure and creating new classes of functions for the study of potential theory on trees.     

Exponentiated generalized linear exponential distribution

A new generalization of the linear exponential distribution is recently proposed by Mahmoud and Alam [1], called as the generalized linear exponential distribution. Another generalization of the linear exponential was introduced by Sarhan and Kundu  and , named as the generalized linear failure rate distribution. This paper proposes a more generalization of the linear exponential distribution which generalizes the two. We refer to this new generalization as the exponentiated generalized linear exponential distribution. The new distribution is important since it contains as special sub-models some widely well known distributions in addition to the above two models, such as the exponentiated Weibull distribution among many others. It also provides more flexibility to analyze complex real data sets. We study some statistical properties for the new distribution. We discuss maximum likelihood estimation of the distribution parameters. Three real data sets are analyzed using the new distribution, which show that the exponentiated generalized linear exponential distribution can be used quite effectively in analyzing real lifetime data.