Resolving the black-hole information paradox by treating time on an equal footing with space

Pure states in quantum field theory can be represented by many-fingered block-time wave functions, which treat time on an equal footing with space and make the notions of “time evolution” and “state at a given time” fundamentally irrelevant. Instead of information destruction resulting from an attempt to use a “state at a given time” to describe semi-classical black-hole evaporation, the full many-fingered block-time wave function of the universe conserves information by describing the correlations of outgoing Hawking particles in the future with ingoing Hawking particles in the past.     

Spontaneous pattern formation with incoherent white light

We present the first experimental observation of modulation instability and spontaneous pattern formation with incoherent white light emitted from an incandescent light bulb. We show experimentally that modulation instability of white light propagating in a noninstantaneous self-focusing medium is a collective effect, where the entire temporal spectrum of the light beam becomes unstable at the same threshold value and collectively forms a pattern with a single periodicity. We experimentally demonstrate that the temporal spectrum of the evolving perturbation self-adjusts to match the collective pattern formation phenomenon.     

Zero–One Law for some Brownian Functionals

We prove that for a>0, (B _t) one-dimensional standard Brownian motion and ₀=inf{t>0 : B _t=0} the following zero–one law is valid

Theoretical and experimental study of the nanoparticle-driven blue phase stabilisation

We have studied theoretically and experimentally the effects of various types of nanoparticles (NPs) on the temperature stability range [Formula: see text] T (BP) of liquid-crystalline (LC) blue phases. Using a mesoscopic Landau-de Gennes type approach we obtain that the defect core replacement (DCR) mechanism yields in the diluted regime [Formula: see text] T (BP)(x) [Formula: see text] 1/(1 - xb) , where x stands for the concentration of NPs and b is a constant. Our calculations suggest that the DCR mechanism is efficient if a local NP environment resembles the core structure of disclinations, which represent the characteristic property of BP structures. These predictions are in line with high-resolution ac calorimetry and optical polarising microscopy experiments using the CE8 LC and CdSe or aerosil NPs. In mixtures with CdSe NPs of 3.5nm diameter and hydrophobic coating the BPIII stability range has been extended up to 20K. On the contrary, the effect of aerosil silica nanoparticles of 7.0nm diameter and hydrophilic coating is very weak.     

Construction of a New Class of Tetracycline Lead Structures with Potent Antibacterial Activity through Biosynthetic Engineering

Antimicrobial resistance and the shortage of novel antibiotics have led to an urgent need for new antibacterial drug leads. Several existing natural product scaffolds (including chelocardins) have not been developed because their suboptimal pharmacological properties could not be addressed at the time. It is demonstrated here that reviving such compounds through the application of biosynthetic engineering can deliver novel drug candidates. Through a rational approach, the carboxamido moiety of tetracyclines (an important structural feature for their bioactivity) was introduced into the chelocardins, which are atypical tetracyclines with an unknown mode of action. A broad‐spectrum antibiotic lead was generated with significantly improved activity, including against all Gram‐negative pathogens of the ESKAPE panel. Since the lead structure is also amenable to further chemical modification, it is a platform for further development through medicinal chemistry and genetic engineering.     

Classical Mechanics Without Determinism

Classical statistical particle mechanics in the configuration space can be represented by a nonlinear Schrödinger equation. Even without assuming the existence of deterministic particle trajectories, the resulting quantum-like statistical interpretation is sufficient to predict all measurable results of classical mechanics. In the classical case, the wave function that satisfies a linear equation is positive, which is the main source of the fundamental difference between classical and quantum mechanics.