Development and production of <Superscript>81</Superscript>Rb/<Superscript>81m</Superscript>Kr radionuclide generator in NPI

A project of ⁸¹Rb production and ⁸¹Rb/^81mKr generator manufacturing is described. ⁸¹Rb nuclide is produced on U-120M cyclotron via Kr(p, 2n)Rb reaction using pressurised gaseous target. Generator of a “dry” type is based on the sorption of ⁸¹Rb on an ion-exchange paper from which the daughter ^81mKr is eluted by air. Parameters of targetry and generator assembly are given. Generator which will be manufactured under pharmaceutical “clean” conditions is intended for lung ventilation studies in nuclear medicine.     

New rapid methods of labelling by radioiodine

New methods for labelling of organic molecules by iodine radionuclides have been developed on the basis of a detailed study of processes occurring during radioiodination. Kits were preparations of iodinated radiophyarmaceuticals (e. g. hippurate, Bengal Rose, sulfobromophythalein). Further iodogene-impregnated filters were developed for labelling of non-iodinated compounds, especially proteins. Their use and preparation is quite simple and easy.     

Radioiodinated fatty acids for myocardial scanning

A simple method for labelling fatty acids with iodine radionuclides is reported. 16-[¹²³I]iodohexadecanoic, 17-[¹²³I]iodoheptadecanoic and 18-[¹²³I]iodooctadecanoic acids were prepared by exchange reaction in ethanolic solution. The best results in biodistribution studies were obtained with 18-[¹²³I]iodooctanoic acid.