Narrow band quantitative and multivariate electroencephalogram analysis of peri-adolescent period

ABSTRACT: BACKGROUND: The peri-adolescent period is a crucial developmental moment of transition from childhood to emergent adulthood. The present report analyses the differences in Power Spectrum (PS) of the Electroencephalogram (EEG) between late childhood (24 children between 8 and 13 years old) and young adulthood (24 young adults between 18 and 23 years old). RESULTS: The narrow band analysis of the Electroencephalogram was computed in the frequency range of 0--20 Hz. The analysis of mean and variance suggested that six frequency ranges presented a different rate of maturation at these ages, namely: low delta, delta-theta, low alpha, high alpha, low beta and high beta. For most of these bands the maturation seems to occur later in anterior sites than posterior sites. Correlational analysis showed a lower pattern of correlation between different frequencies in children than in young adults, suggesting a certain asynchrony in the maturation of different rhythms. The topographical analysis revealed similar topographies of the different rhythms in children and young adults. Principal Component Analysis (PCA) demonstrated the same internal structure for the Electroencephalogram of both age groups. Principal Component Analysis allowed to separate four subcomponents in the alpha range. All these subcomponents peaked at a lower frequency in children than in young adults. CONCLUSIONS: The present approaches complement and solve some of the incertitudes when the classical brain broad rhythm analysis is applied. Children have a higher absolute power than young adults for frequency ranges between 0-20 Hz, the correlation of Power Spectrum (PS) with age and the variance age comparison showed that there are six ranges of frequencies that can distinguish the level of EEG maturation in children and adults. The establishment of maturational order of different frequencies and its possible maturational interdependence would require a complete series including all the different ages.     

Copper and iron interactions with angiotensin-converting enzyme inhibitors. A study by fast-atom bombardment tandem mass spectrometry

Fast atom bombardment, combined with high-energy collision-induced tandem mass spectrometry, has been used to investigate gas-phase metal-ion interactions with captopril, enalaprilat and lisinopril, all angiotensin-converting enzyme inhibitors.Suggestions for the location of metal-binding sites are presented. For captopril, metal binding occurs most likely at both the sulphur and the nitrogen atom. For enalaprilat and lisinopril, binding preferably occurs at the amine nitrogen. Copyright 1999 John Wiley & Sons, Ltd.     

Water and the relationship to the crystal structure stability of azithromycin

Journal of Thermal Analysis and Calorimetry - This study investigated the solid-state physical stabilities of azithromycin dihydrate (AZM-DH), thermally prepared anhydrate and hemihydrate...     

Coordination mode of cyclohex-1-enylolonium cation and bridging pyridyl derivatives as gem-diol chelates to rhenium(I) and (VII)

Transition Metal Chemistry - Rhenium(I) and (VII) complexes with cyclohex-1-enylolonium cation and bridging pyridyl derivatives are reported. Additionally, the CO-bridged pyridyl and their related...     

Synthesis,crystal structure and docking studies of tetracyclic 10‐iodo‐1,2‐dihydroisoquinolino[2,1‐b][1,2,4]benzothiadiazine 12,12‐dioxide and its precursors

The title compound, 10‐iodo‐1,2‐dihydroisoquinolino[2,1‐b][1,2,4]benzothiadiazine 12,12‐dioxide, C₁₅H₁₁IN₂O₂S ( 8 ), was synthesized via the metal‐free intramolecular N‐iodosuccinimide (NIS)‐mediated radical oxidative sp³‐C—H aminative cyclization of 2‐(2′‐aminobenzenesulfonyl)‐1,3,4‐trihydroisoquinoline, C₁₅H₁₆N₂O₂S ( 7 ). The amino adduct 7 was prepared via a two‐step reaction, starting from the condensation of 2‐nitrobenzenesulfonyl chloride ( 4 ) with 1,2,3,4‐tetrahydroisoquinoline ( 5 ), to afford 2‐(2′‐nitrobenzenesulfonyl)‐1,3,4‐trihydroisoquinoline, C₁₅H₁₄N₂O₄S ( 6 ), in 82% yield. The catalytic hydrogenation of 6 with hydrogen gas, in the presence of 10% palladium‐on‐charcoal catalyst, furnished 7 . Products 6 – 8 were characterized by their melting points, IR and NMR (¹H and ¹³C) spectroscopy, and single‐crystal X‐ray diffraction. The three compounds crystallized in the monoclinic space group, with 7 exhibiting classical intramolecular hydrogen bonds of 2.16 and 2.26 Å. All three crystal structures exhibit centrosymmetric pairs of intermolecular C—H…π(ring) and/or π–π stacking interactions. The docking studies of molecules 6 , 7 and 8 with deoxyribonucleic acid (PDB id: 1ZEW ) revealed minor‐groove binding behaviours without intercalation, with 7 presenting the most favourable global energy of the three molecules. Nonetheless, molecule 8 interacted strongly with the DNA macromolecule, with an attractive van der Waals energy of ?15.53 kcal mol^?1.     

Modal decomposition method for modeling the interaction of Lamb waves with cracks

The interaction of the low-order antisymmetric (a0) and symmetric (s0) Lamb waves with vertical cracks in aluminum plates is studied. Two types of slots are considered: (a) internal crack symmetrical with respect to the middle plane of the plate and (b) opening crack. The modal decomposition method is used to predict the reflection and transmission coefficients and also the through-thickness displacement fields on both sides of slots of various heights. The model assumes strip plates and cracks, thus considering two-dimensional plane strain conditions. However, mode conversion (a0 into s0 and vice versa) that occurs for single opening cracks is considered. The energy balance is always calculated from the reflection and transmission coefficients, in order to check the validity of the results. These coefficients together with the through-thickness displacement fields are also compared to those predicted using a finite element code widely used in the past for modeling Lamb mode diffraction problems. Experiments are also made for measuring the reflection and transmission coefficients for incident a0 or s0 lamb modes on opening cracks, and compared to the numerical predictions.     

Numerical predictions and experiments on the free-plate edge mode

In this paper, te edge mode variation is studied with three different methods: the reciprocal work method, already used by Torvik [J. Acoust. Soc. Am. 41 (1967) 346] to model this phenomenon, the S-parameter method and a finite element model that are applied for the first time to the study of the edge resonance. Moreover, laser probe measurements of the edge mode have also been performed and compared to the numerical predictions. The good agreement between the numerical predictions and the experimental data allows full understanding of the resonant phenomenon. The edge resonance is linked to the strong increase in amplitude of two complex Lamb waves, and the edge mode is proved to radiate into the plate as the first symmetrical Lamb mode S(0). Displacements at the edge and away from the edge have been computed and measured to evaluate the spatial and temporal behaviour of the edge mode. The dependence of the edge resonance frequency and amplitude on the Poisson coefficient has also been studied.     

Guided waves propagating in sandwich structures made of anisotropic,viscoelastic, composite materials

The propagation of Lamb-like waves in sandwich plates made of anisotropic and viscoelastic material layers is studied. A semi-analytical model is described and used for predicting the dispersion curves (phase velocity, energy velocity, and complex wave-number) and the through-thickness distribution fields (displacement, stress, and energy flow). Guided modes propagating along a test-sandwich plate are shown to be quite different than classical Lamb modes, because this structure does not have the mirror symmetry, contrary to most of composite material plates. Moreover, the viscoelastic material properties imply complex roots of the dispersion equation to be found that lead to connections between some of the dispersion curves, meaning that some of the modes get coupled together. Gradual variation from zero to nominal values of the imaginary parts of the viscoelastic moduli shows that the mode coupling depends on the level of material viscoelasticity, except for one particular case where this phenomenon exists whether the medium is viscoelastic or not. The model is used to quantify the sensitivity of both the dispersion curves and the through-thickness mode shapes to the level of material viscoelasticity, and to physically explain the mode-coupling phenomenon. Finite element software is also used to confirm results obtained for the purely elastic structure. Finally, experiments are made using ultrasonic, air-coupled transducers for generating and detecting guided modes in the test-sandwich structure. The mode-coupling phenomenon is then confirmed, and the potential of the air-coupled system for developing single-sided, contactless, NDT applications of such structures is discussed.