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Dr. Wouter F. J. Hogendorf Dr. Nicolas Gisch Prof. Mikael Bols Prof. Christian Marcus Pedersen 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(42):13511-13516
The emergence of hypervirulent resistant strains have made Clostridium difficile a notorious nosocomial pathogen and has resulted in a renewed interest in preventive strategies, such as vaccines based on (synthetic) cell wall antigens. Recently, the structure of the lipoteichoic acid (LTA) of this species has been elucidated. Additionally, this LTA was found to induce the formation of protective antibodies against C. difficile in rabbits and mice. The LTA from C. difficile is isolated as a microheterogenous mixture, differing in size and composition, impeding any structure–activity relationship studies. To ensure reliable biological results, pure and well‐defined synthetic samples are required. In this work the total synthesis of LTAs from C. difficile with defined chain length is described and the initial biological results are presented. 相似文献
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Hogendorf WF Meeuwenoord N Overkleeft HS Filippov DV Laverde D Kropec A Huebner J Van der Marel GA Codée JD 《Chemical communications (Cambridge, England)》2011,47(31):8961-8963
This communication describes the first automated solid phase synthesis of teichoic acids (TAs) and the preparation by this method of a number of well-defined TA structures, which were probed for their antigenicity. An opsonophagocytic killing assay revealed a clear TA-length-activity relationship and indicated a promising candidate for future vaccine development. 相似文献
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An efficient synthetic route to the phosphoramidite of a menthol functionalized guanosine analog is presented. Two procedures were executed for the key introduction of the 6′-allyl menthyl moiety. Stille vinylation on 6-O-tosylguanosine followed by cross-metathesis using an excess of allyl menthyl ether proved to be less efficient than a Stille coupling on the same tosylate using an advanced menthyl-allyl stannane derivative. Incorporation of the modified nucleoside using the phosphoramidite method into a DNA 50-mer proceeded uneventfully. 相似文献
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Hogendorf WF Lameijer LN Beenakker TJ Overkleeft HS Filippov DV Codée JD Van der Marel GA 《Organic letters》2012,14(3):848-851
The use of perfluorooctylpropylsulfonylethanol as a new phosphate protecting group and fluorous linker is evaluated in the stepwise solution phase synthesis of a number of biologically relevant (carbohydrate substituted) glycerol teichoic acid fragments. Teichoic acid fragments, up to the dodecamer level, were assembled by means of phosphoramidite chemistry, using a relatively small excess of the building blocks and a repetitive efficient purification procedure of the protected intermediates by fluorous solid phase extraction (F-SPE). 相似文献
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Pressure is accepted theoretically as a useful variable. However in a studies on liquid or solid samples, it is still relatively unusual for pressure to be used as an experimental variable. The reluctance of experimentalists to use this theoretically attractive variable is caused mainly by the technical difficulties associated with the use of sufficiently high pressures. In this talk I will try to show that in many cases the experimental limitations are no longer those introduced by the use of high pressures. High pressure spectroscopic studies clearly imply the use of high pressure spectroscopic cells. A brief account will therefore be given of the various types of high pressure optical cells which are currently being used for spectroscopic studies. Each individual high pressure spectroscopic study has its own special justification. However there are a few quite general observations that can be made which cover many of the specific objectives of individual high pressure spectroscopic studies. For example:(i) pressure induced frequency shifts carry unambiguous information about anharmonic terms in the relevant potential function (i.e. the potential V is a function of distance d. therefore pressure can be used to change d and study V.)(ii) all known materials undergo structural phase transitions if the form which is thermodynamically stable under ambient conditions is compressed to high enough pressures: these high pressure phases should be studied.(iii) as the application of pressure forces a material towards a phase transition, the spectroscopic study can be used to gain information about the approaching structural instability.(iv) virtually all infrared and Raman spectra contain examples of Fermi resonance which confuse the interpretation of the spectra and the effects of pressure are valuable aids to the correct assignment of the resonating levels.(v) pressure induced frequency shifts can often give extra information to help with the more reliable assignment of features within a spectrum.The above points will be discussed and illustrated by examples chosen mainly from recent work by members of the spectroscopy group at King's College London. 相似文献
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The lattice dynamics of InAs under variable hydrostatic pressures is investigated on the basis of an ‘11-parameter’ rigid-ion model (RIM). The calculated phonon dispersion curves are in satisfactory agreement with the neutron scattering data (available for the TA modes only) measured at room temperature and atmospheric pressure. The one- and two-phonon densities of states functions and mode Gruneisen parameters have been computed at two arbitrary hydrostatic pressures. The effect of high pressure on the phonon dispersion curves is shown to lead to a typical ‘softening’ in the transverse acoustic modes and eventually to a phase trnasformation of the compound. 相似文献
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Dinkelaar J van den Bos LJ Hogendorf WF Lodder G Overkleeft HS Codée JD van der Marel GA 《Chemistry (Weinheim an der Bergstrasse, Germany)》2008,14(30):9400-9411
The glycosylation properties of gulopyranosides have been mapped out, and it is shown that gulose has an intrinsic preference for the formation of 1,2-cis-glycosidic bonds. It is postulated that this glycosylation behaviour originates from nucleophilic attack at the oxacarbenium ion, which adopts the most favourable 3H4 conformation. Building on the stereoselectivity of gulose, a guluronic acid alginate trisaccharide was assembled for the first time by using gulopyranosyl building blocks. 相似文献
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Agata Hogendorf Adam S. Hogendorf Rafa Kurczab Grzegorz Sataa Bernadeta Szewczyk Paulina Cielik Gniewomir Latacz Jadwiga Handzlik Tomasz Lenda Katarzyna Kaczorowska Jakub Staro Ryszard Bugno Beata Duszyska Andrzej J. Bojarski 《Molecules (Basel, Switzerland)》2021,26(15)
A series of N-skatyltryptamines was synthesized and their affinities for serotonin and dopamine receptors were determined. Compounds exhibited activity toward 5-HT1A, 5-HT2A, 5-HT6, and D2 receptors. Substitution patterns resulting in affinity/activity switches were identified and studied using homology modeling. Chosen hits were screened to determine their metabolism, permeability, hepatotoxicity, and CYP inhibition. Several D2 receptor antagonists with additional 5-HT6R antagonist and agonist properties were identified. The former combination resembled known antipsychotic agents, while the latter was particularly interesting due to the fact that it has not been studied before. Selective 5-HT6R antagonists have been shown previously to produce procognitive and promnesic effects in several rodent models. Administration of 5-HT6R agonists was more ambiguous—in naive animals, it did not alter memory or produce slight amnesic effects, while in rodent models of memory impairment, they ameliorated the condition just like antagonists. Using the identified hit compounds 15 and 18, we tried to sort out the difference between ligands exhibiting the D2R antagonist function combined with 5-HT6R agonism, and mixed D2/5-HT6R antagonists in murine models of psychosis. 相似文献
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Raman and resonance-Raman spectra of the I?3 ion isolated within CsI crystals have been studied using 647 nm and 488 nm exciting radiation. Sample temperatures between 300 and 20 K have been used. Eleven overtones of the symmetric stretching mode (nν1) have been observed in the resonance-Raman spectrum excited by the 488 nm Ar+ laser line. Bands centred at 153, 170, 264 and 304 cm?1 have been assigned as ν3, 2ν2, ν1+ν3 and 2ν3(Σ+) respectively. The remaining structure between the nν1 lines has been assigned as due to combinations of these lines with the lattice vibrations of the CsI crystal. 相似文献
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