全文获取类型
收费全文 | 995篇 |
免费 | 35篇 |
国内免费 | 5篇 |
专业分类
化学 | 853篇 |
晶体学 | 5篇 |
力学 | 5篇 |
数学 | 37篇 |
物理学 | 135篇 |
出版年
2023年 | 5篇 |
2021年 | 10篇 |
2020年 | 7篇 |
2019年 | 18篇 |
2018年 | 12篇 |
2017年 | 8篇 |
2016年 | 12篇 |
2015年 | 20篇 |
2014年 | 23篇 |
2013年 | 40篇 |
2012年 | 63篇 |
2011年 | 68篇 |
2010年 | 28篇 |
2009年 | 33篇 |
2008年 | 57篇 |
2007年 | 77篇 |
2006年 | 50篇 |
2005年 | 55篇 |
2004年 | 60篇 |
2003年 | 48篇 |
2002年 | 66篇 |
2001年 | 13篇 |
2000年 | 15篇 |
1999年 | 10篇 |
1998年 | 6篇 |
1997年 | 11篇 |
1996年 | 4篇 |
1995年 | 10篇 |
1994年 | 5篇 |
1993年 | 5篇 |
1992年 | 10篇 |
1991年 | 8篇 |
1990年 | 9篇 |
1989年 | 8篇 |
1988年 | 13篇 |
1987年 | 5篇 |
1986年 | 7篇 |
1985年 | 13篇 |
1984年 | 10篇 |
1983年 | 6篇 |
1982年 | 14篇 |
1981年 | 11篇 |
1980年 | 12篇 |
1979年 | 9篇 |
1978年 | 13篇 |
1977年 | 4篇 |
1976年 | 6篇 |
1975年 | 6篇 |
1974年 | 4篇 |
1967年 | 7篇 |
排序方式: 共有1035条查询结果,搜索用时 468 毫秒
1.
2.
Application of the 19F NMR technique to observe binding of the general anesthetic halothane to human serum albumin. 总被引:1,自引:0,他引:1
Kazuaki Shikii Satoshi Sakurai Hiroaki Utsumi Hiroko Seki Mitsuru Tashiro 《Analytical sciences》2004,20(10):1475-1477
19F NMR techniques were employed to characterize the binding property of the widely used general anesthetic halothane with human serum albumin (HSA). It was found that 19F(1H) NOE and 2D 1H-19F HOESY experiments detected intermolecular NOEs between halothane 19F and HSA protons. Measurements of the diffusion coefficients for halothane were also carried out by 1H and 19F NMR, indicating the interaction of halothane with HSA. The present results indicate that these techniques are very suitable to identify a fluorine-containing ligand binding with a protein receptor in the drug-discovery process. 相似文献
3.
Isao Tanikawa Nobuo Hirakawa Hiroko Hosono Hiroshi Nakamura 《Analytical sciences》2007,23(11):1267-1274
Hydro-membrane gas chromatography (HMGC) is achieved by the annular condensation of water in a capillary column at less than 70 degrees C. The annular membrane of water is formed as a result of the wettability of the stationary phase, which is induced at a water contact angle ranging from 75 degrees to 79 degrees, as derived from a solubility parameter (delta) range of 15.7 +/- 0.3 MPa(1/2) of the coated resin. The range of the liquid to gas volume ratio (beta) required to support the annular membrane should be kept between 0.00005 and 0.0003. In the case of a 0.25-mm i.d. column, the ratio can be set by the combination of a 0.1 to 0.2 microl min(-1) water supply rate and helium gas flow rate. Separation by HMGC develops not only a gas-solid partition but also a focusing effect on the water membrane. One feature of HMGC is that it gives a non-adsorption chromatogram based on the blocking effect of pre-adsorbed water; furthermore, despite the presence of a relatively large quantity of water, the electron impact ionization efficiency is kept the same as in the usual GC/MS condition. The detection limit with the injection of 1 microl of aquatic solution was estimated to be less than 0.1 ppb of low-molecular-weight fatty acids with s/n = 5 on a mass chromatogram at m/z 45. The HMGC/EI-MS system can be applied to the trace analysis of C1 to C3 volatile acids, volatile inorganic acids, and halogenated organic acids in water. 相似文献
4.
5.
6.
7.
We study the limit theorem related to the interface of the three-dimensional Ising model. Dobrushin proved that the interface does not fluctuate and becomes rigid for sufficiently large. We define the random fieldX
L
(t, s), 0t, s1, on the interface, and prove that XL(t, s) converges to the Brownian sheet as L for sufficiently large, whereL denotes the size of the system. This result does not mean that the interface itself converges to the Brownian sheet. 相似文献
8.
Ikedou K Yamamoto H Nagashima H Nemoto N Tashiro K 《The journal of physical chemistry. B》2005,109(21):10668-10675
We synthesized four branched n-alkane samples C35-C1, C35-C4, C35-C6, and C35-C4Ph with the same number of carbons as the main chain, n = 35, to which the methyl, butyl, hexyl, and butyl phenyl groups were respectively attached at the middle, and also the corresponding linear homologue of C35, and studied their crystalline structures from DSC, IR, and Raman spectroscopy, X-ray diffraction measurement, and computer simulation. Solid-solid phase transitions characteristic of linear alkane C35 are not observed for any branched alkanes, and their melting temperatures Tm are lowered to 325.2, 318.5, 314.3, and 314.1K, respectively. Main chains of branched alkane molecules are not folded, irrespective of length and chemical structure of branches, but are extended to take the planar zigzag form in the solid state. The branches of C35-C4 and C35-C6 are also aligned inside the crystal in the extended form. Data analyses on solution-grown crystallized samples reveal that, with increasing the branch length, their crystal structures transform from polymorphic forms of the orthorhombic (P2(1)2(1)2(1)) and the triclinic (P) for C35-C1 and C35-C4 to the unique triclinic form for C35-C6 and C35-C4Ph, so as to minimize extra surface energy invoked by introduction of long branches. 相似文献
9.
Goto S Masuda K Miura M Kanazawa K Sasaki M Masui M Shiramizu M Terada H Chuman H 《Chemical & pharmaceutical bulletin》2002,50(4):445-449
We measured the affinity of more than 20 sugars with concanavalin A (ConA) by an optical biosensor (surface plasmon resonance sensor) using asialofetuin (ASF) as an immobilized binding partner of ConA. We determined kinetic parameters of the effects of sugars on the dissociation of ConA from ASF quantitatively, and the structural requirements of the functional groups of sugars for binding with ConA. We found that the affinity of ConA for sugars is dependent on its conformation induced by interaction with the binding partner. In addition, the results showed that optical biosensor system is well mimics the interaction of ConA with sugars in biomembrane. 相似文献
10.
Matsuo G Kawamura K Hori N Matsukura H Nakata T 《Journal of the American Chemical Society》2004,126(44):14374-14376
Brevetoxin-B (BTX-B), produced by the red tide organism, Gymnodium breve Davis, is the first member of marine polycyclic ethers to be structurally elucidated and one of the most potent neurotoxins. The structural feature is a trans-fused polycyclic ether ring system with 23 stereocenters. Its unique, complex structure and potent biological activity have attracted the attention of synthetic organic chemists. Total synthesis of BTX-B has been accomplished via the coupling of the ABCDEFG and IJK-ring segments, each ether ring of which was stereoselectively and efficiently constructed on the basis of SmI2-induced intramolecular cyclization, 6-endo-cyclization of hydroxy epoxide, ring-closing olefin metathesis, and SmI2-induced intramolecular Reformatsky-type reaction. Several kinds of double reactions at the left and right sides were efficiently used through the synthesis. 相似文献