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1.
Crommentuyn KM Rosing H Nan-Offeringa LG Hillebrand MJ Huitema AD Beijnen JH 《Journal of mass spectrometry : JMS》2003,38(2):157-166
HIV protease inhibitors are important antiretroviral drugs which have substantially reduced the morbidity and mortality associated with HIV-1 infection. Recent data have shown relationships between plasma concentrations of the protease inhibitors and clinical response, which makes therapeutic drug monitoring valuable. We have developed and validated an assay, using liquid chromatography coupled with electrospray tandem mass spectrometry (LC/MS/MS), for the routine quantification of the six licensed protease inhibitors (amprenavir, indinavir, lopinavir, nelfinavir, ritonavir and saquinavir) and the pharmacologically active nelfinavir metabolite M8 in plasma. The sample pretreatment consisted of protein precipitation with a mixture of methanol and acetronitrile using only 100 microl of plasma. Chromatographic separation was performed on an Inertsil ODS3 column (50 x 2.0 mm i.d., particle size 5 microm), with a quick stepwise gradient using an acetate buffer (pH 5) and methanol, at a flow rate of 0.5 ml min(-1). The analytical run time was 5.5 min. The use of a 96-well plate autosampler allowed batch sizes up to 150 patient samples. The triple-quadrupole mass spectrometer was operated in the positive ion mode and multiple reaction monitoring was used for drug quantification. The method was validated over the concentration ranges 0.01-10 microg ml(-1) for indinavir and saquinavir, 0.1-10 microg ml(-1) for amprenavir, 0.05-10 microg ml(-1) for nelfinavir and ritonavir, 0.1-20 microg ml(-1) for lopinavir and 0.01-5 microg ml(-1) for M8. Saquinavir-d(5) and indinavir-d(6) were used as internal standards. The coefficients of variation were always <10% for both intra-day and inter-day precisions for each compound. Mean accuracies were also between the designated limits (+/-15%). The validated concentration ranges proved to be adequate in daily practice. This robust and fast LC/MS/MS assay is now successfully applied for routine therapeutic drug monitoring and pharmacokinetic studies in our hospital. 相似文献
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Hillebrand und Cain 《Fresenius' Journal of Analytical Chemistry》1920,59(8-9):368-369
Ohne Zusammenfassung 相似文献
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W. F. Hillebrand 《Fresenius' Journal of Analytical Chemistry》1914,53(3):195-196
Ohne Zusammenfassung 相似文献
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Photonic crystal structures (PCs) of tetragonal lattice type are introduced and studied. They feature complete three-dimensional (3D) photonic bandgaps (PBGs). The PC design is based on two systems of ordered, parallel pores being perpendicular to each other. For increasing pore radii, the pore systems interpenetrate and an inverted woodpile geometry arises. The size of the 3D bandgaps depends on the ratio of the cell parameters Lx, Ly, and Lz, the pore radii and the refractive index of the dielectric material. If realized as a silicon/air structure, the maximum 3D gap is larger than 25%. A possible fabrication route for the near-infrared is based on 2D macroporous silicon where perpendicular pores are drilled, e.g., by focused-ion-beam etching. The dispersion behaviour of the PCs is theoretically analysed (band structures, density-of-states), systematically varying all relevant parameters. The optimization of the PBG sizes as well as a possible tunability of the PBG energies are discussed. 相似文献
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Nising CF Hillebrand S Rodefeld L 《Chemical communications (Cambridge, England)》2011,47(14):4062-4073
Natural products play an important role as lead structures for the identification of novel active ingredients in crop protection. As it is the case in the pharmaceutical industry, however, many crop protection companies have substantially decreased their in-house efforts in natural product exploration. Therefore, joint projects with academic research groups become more and more important in the field. This review describes several examples for successful collaborations in the field of fungicidal natural products. 相似文献
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W. R. Schoeller A. R. Powell O. Hahn K. E. Pütter E. S. Simpson W. F. Hillebrand G. E. F. Lundell O. Ruff E. Schiller W. P. Headden H. Pied H. W. Webb R. J. Meyer O. Hauser W. B. Giles R. C. Wells E. F. Waterhouse G. T. Prior E. C. Deering L. Finckh J. H. Muller J. W. Mellor E. W. Todd V. Schwarz G. W. Sears W. D. Treadwell 《Analytical and bioanalytical chemistry》1934,99(5-6):205-227
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N. Allen N. H. Furman E. Krause R. Becker P. Pfeiffer K. Schnurmann R. F. Chambers Ph. C. Scherer W. F. Hillebrand G. E. F. Lundell D. S. Reynolds W. H. Roß K. D. Jacob O. B. Winter Lillian Butler F. J. Frere G. Batchelder V. W. Meloche I. Tananaeff H. Flisik E. C. Roper E. B. R. Prideaux P. Drawe W. Rehwinkel L. Dupare P. Wenger G. Graz 《Analytical and bioanalytical chemistry》1934,96(5-6):211-223