排序方式: 共有1条查询结果,搜索用时 15 毫秒
1
1.
Saholinirina Randrianarivo Claudine Rasolohery Sitraka Rafanomezantsoa Heriniaina Randriamampionona Liti Haramaty Roger Marie Rafanomezantsoa Eric H. Andrianasolo 《Molecules (Basel, Switzerland)》2021,26(18)
Chemical and biological investigation of the Madagascar endemic plant Saldinia proboscidea led to the isolation of an isomer of artemisinin, (−)-6-epi-artemisinin (2). Its structure was elucidated using a combination of NMR and mass spectrometry. The absolute configuration was established by chemical syntheses of compound 2 as well as a new stereoisomer (3). The comparable bioactivities of artemisinin (1) and its isomer (−)-6-epi-artemisinin (2) revealed that this change in configuration was not critical to their biological properties. Bioactivity was assessed using an apoptosis induction assay, a SARS-CoV-2 inhibitor assay, and a haematin polymerization inhibitory activity (HPIA) assay. This is the first report of an artemisinin-related compound from a genus not belonging to Artemisia and it is the first isolation of an artemisinin-related natural product that is the opposite enantiomeric series relative to artemisinin from Artemisia annua. 相似文献
1