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排序方式: 共有87条查询结果,搜索用时 15 毫秒
1.
DETECTION OF DNA-PSORALEN PHOTOADDUCTS in situ 总被引:1,自引:0,他引:1
ZOFIA ZAREBSKA† MARIA JARZABEK-CHORZELSKA ‡ GENOWEFA RZSA WIESLAW GLISKI MARIA PAWIKA TADEUSZ CHORZELSKI STEFANIA JABLOKA 《Photochemistry and photobiology》1984,39(3):307-312
Abstract— An immunological method, with the use of specific immune serum, has been developed for detection of 8-methoxypsoralen (8-MOP) photoadducts to DNA, formed in situ in cell nuclei, after combined treatment with 8MOP and UV-A irradiation (Zarçbska et al. , 1978). Lymphocytes fixed on slides or in suspension, and cryostat sections of different mammalian tissues, served as antigenic substrate, after treatment with 8-MOP and UV-A in vitro. Specific fluorescence in these substrates was detected in the nuclei after treatment with 30 ˜ 140 kJ/m2 UV-A in the presence of 0.1-0.3 μg/cm2 8-MOP. PHA-stimulated-lymphocytes appeared to be the most sensitive substrate.
However, hairless mice treated with high doses of UV-A in vivo , 70 ˜ 360 kJ/m2 did not reveal a specific fluorescence of epidermal nuclei, unless a high local concentration of 8-MOP was attained.
The apparent discrepancy in the level of photoadduct detection between the in vitro and in vivo treated specimens was explained by the low number of DNA-8-MOP-photoadducts formed in vivo under these experimental conditions. The relevance of these findings to the role of DNA-8-MOP-photoadducts formed during PUVA photochemotherapy is discussed. 相似文献
However, hairless mice treated with high doses of UV-A in vivo , 70 ˜ 360 kJ/m
The apparent discrepancy in the level of photoadduct detection between the in vitro and in vivo treated specimens was explained by the low number of DNA-8-MOP-photoadducts formed in vivo under these experimental conditions. The relevance of these findings to the role of DNA-8-MOP-photoadducts formed during PUVA photochemotherapy is discussed. 相似文献
2.
P.J. Bussey C. Raine J.G. Rutherglen P.S.L. Booth L.J. Carroll G.R. Court P.R. Daniel A.W. Edwards R. Gamet C.J. Hardwick P.J. Hayman J.R. Holt J.N. Jackson W.H. Range F.H. Combley W. Galbraith V.H. Rajaratnam C. Sutton 《Nuclear Physics B》1979,154(3):492-502
The polarisation parameters Σ, P and T have been measured for the process γp→π0p in the photon energy range 1300–2100 MeV and c.m. angles between 30° and 110°, in an experiment with a polarised beam and polarised target. The results are compared with a recent theoretical analysis which fits data from threshold to 16 GeV. The new data are in general agreement with the analysis, but with some significant discrepancies in detail. 相似文献
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The Strength of Cartan's Version of Nevanlinna Theory 总被引:2,自引:0,他引:2
In 1933 Henri Cartan proved a fundamental theorem in Nevanlinnatheory, namely a generalization of Nevanlinna's second fundamentaltheorem. Cartan's theorem works very well for certain kindsof problems. Unfortunately, it seems that Cartan's theorem,its proof, and its usefulness, are not as widely known as theydeserve to be. To help give wider exposure to Cartan's theorem,the simple and general forms of the theorem are stated here.A proof of the general form is given, as well as several applicationsof the theorem. 2000 Mathematics Subject Classification 30D35. 相似文献
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Regan J. Anderson Benjamin J. Compton Ching-wen Tang Astrid Authier-Hall Colin M. Hayman Gene W. Swinerd Renata Kowalczyk Paul Harris Margaret A. Brimble David S. Larsen Olivier Gasser Robert Weinkove Ian F. Hermans Gavin F. Painter 《Chemical science》2015,6(9):5120-5127
It is known that T cells can eliminate tumour cells through recognition of unique or aberrantly expressed antigens presented as peptide epitopes by major histocompatibility complex (MHC) molecules on the tumour cell surface. With recent advances in defining tumour-associated antigens, it should now be possible to devise therapeutic vaccines that expand specific populations of anti-tumour T cells. However there remains a need to develop simpler efficacious synthetic vaccines that possess clinical utility. We present here the synthesis and analysis of vaccines based on conjugation of MHC-binding peptide epitopes to α-galactosylceramide, a glycolipid presented by the nonpolymorphic antigen-presenting molecule CD1d to provoke the stimulatory activity of type I natural killer T (NKT) cells. The chemical design incorporates an enzymatically cleavable linker that effects controlled release of the active components in vivo. Chemical and biological analysis of different linkages with different enzymatic targets enabled selection of a synthetic vaccine construct with potent therapeutic anti-tumour activity in mice, and marked in vitro activity in human blood. 相似文献
7.
D. F. Hayman und H. K. Alber 《Fresenius' Journal of Analytical Chemistry》1943,126(2):72-76
Ohne Zusammenfassung 相似文献
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Two routes for the synthesis of potent BCRP inhibitor—Ko143 are reported. The key intermediate, 6-methoxytryptophan derivative, was synthesized by an improved procedure, ytterbium triflate-promoted coupling between 6-methoxyindole and optically active 1-benzyl-2-methyl-(S)-1,2-aziridinecarboxylate in the second protocol. 相似文献
10.
ABSTRACT. Let G be the group ?[t, t ?1] x ?. By studying the action of the braid group Bn on the set Gn , we obtain representations of Bn into a wreath product of the symmetric group and the general linear group over ?[t, t ?1]. This in particular recovers the Burau representation of the braid group. Furthermore, some quotients of the braid group are obtained by using the representations found. 相似文献