排序方式: 共有19条查询结果,搜索用时 46 毫秒
1.
BIOLOGICAL ACTIVITIES OF PHTHALOCYANINES-X. SYNTHESES AND ANALYSES OF SULFONATED PHTHALOCYANINES 总被引:5,自引:0,他引:5
Hasrat Ali Réjean Langlois J. Richard Wagner Nicole Brasseur Benoit Paquette Johan E. VAN Lier 《Photochemistry and photobiology》1988,47(5):713-717
Abstract— Synthetic methods to obtain selectively sulfonated metallo phthalocyanines are compared. Both condensation and direct sulfonation procedures lead to mixtures of mono- to tetrasulfonated products which are resolved by reverse phase liquid chromatography in buffered aqueous-methanol. The proportion of sulfonated derivatives is examined as a function of the starting reagents in the case of the condensation method, and as a function of the temperature and reaction time in the case of the direct sulfonation procedure. The number of sulfonate groups per phthalocyanine molecule is determined by oxidative degradation of the phthalocyanine ring followed by quantitative chromatographic analysis of the sulfophthalamide and phthalamide fragments. 相似文献
2.
Structure-Photodynamic Activity Relationships of a Series of 4-Substituted Zinc Phthalocyanines 总被引:1,自引:0,他引:1
Philippe Margaron Marie-Josée Grégoire Vladimir asnár † Hasrat Ali Johan E. van Lier ‡ 《Photochemistry and photobiology》1996,63(2):217-223
Abstract— Radioiodinated zinc phthalocyanine including [125I]ZnPcI4 and differently sulfonated [65Zn]ZnPcS (ZnPcS4, ZnPcS3, ZnPcS2 and ZnPcS1.75, a mixture of adjacent di and 25% mono) were prepared in order to study cell uptake and release kinetics in EMT-6 cells. The same compounds were evaluated for their in vitro phototoxicity and the biological parameters were compared to partition coefficients to arrive at quantitative structure-activity relationships (QSAR). At 1 μM in 1% serum, at 37°C, all dyes showed rapid cell uptake during the first hour followed by a slow accumulation phase. After 24 h, the highest cellular concentration was observed with the lipophilic ZnPcI4, followed by the amphiphilic ZnPcS2 and ZnPcS1.75. The hydrophilic ZnPcS4 and ZnPcS3 showed lower uptake. Dye release from dyeloaded cells during incubation in dye-free medium could reach up to 60% and was shown to depend mainly on the amount of drug incorporated rather than the type of compound. These results suggest that care should be taken in interpreting dye toxicity data, which involve in vitro cell manipulations in dye-free medium, particularly during in vitro/in vivo protocols. The EMT-6 cell survival after 1 h or 24 h incubation with 1 μM dye in 1% serum followed by exposure to red light was assessed by means of the colorimetric 3-(4,5-dimethylthiazol-2-yl)-diphenyl-tetrazolium bromide (MTT) assay. Photocytotoxicities correlated inversely with the tendencies of the dyes to aggregate. Increased dye uptake by the cells also correlated with their activities, except for the lipophilic ZnPcI4, which showed the highest cell uptake but little phototoxicity. The QSAR between phototoxicity and the log of the partition coefficients (phosphate-buffered saline and n-octanol) gave a parabola with optimal partition values corresponding to the adjacent sulfonated ZnPcS2. 相似文献
3.
Hasrat Ali 《Tetrahedron letters》2009,50(3):337-4397
Covalently linked phthalocyanine-phthalocyanine (Pc-Pc) heterodimers and Pc-Pc triad phthalocyanines connected through phenyl-phenyl (C-C) linkages are prepared using phthalocyanine-boronate (Suzuki Pc-synthon) and palladium catalyst. 相似文献
4.
Tuhina Manna Farook Rahaman Sabiruddin Molla Jhumpa Bhadra Hasrat Hussain Shah 《General Relativity and Gravitation》2018,50(5):54
In this paper we have investigated the gravitational lensing phenomenon in the strong field regime for a regular, charged, static black holes with non-linear electrodynamics source. We have obtained the angle of deflection and compared it to a Schwarzschild black hole and Reissner Nordström black hole with similar properties. We have also done a graphical study of the relativistic image positions and magnifications. We hope that this method may be useful in the detection of non-luminous bodies like this current black hole. 相似文献
5.
Hasrat Ali 《Tetrahedron letters》2008,49(51):7253-7255
Covalently C-C linked Pc-Pc homo-dimers (ortho and meta) were synthesized from their corresponding Pc halide precursors using a Pd-catalyzed homo-coupling reaction. Photophysical data reveal energy transfer between the Pc moieties resulting in the appearance of new red-shift Q-bands that correlate to the planarity and dihedral angle between the subunit. 相似文献
6.
Nicole Brasseur Hasrat Ali Réjean Langlois Johan E. VAN Lier 《Photochemistry and photobiology》1988,47(5):705-711
Abstract— Zinc phthalocyanines sulfonated to different degrees are tested for their ability to sensitizeV–79 Chinese hamster cells andEMT–6 mouse mammary tumors to red light. In vitro , the lower sulfonated derivatives were the most active with the exception of the poorly water-soluble monosulfonated dye. An isomeric mixture of tetrasulfonated derivatives obtained via direct sulfonation was ten times more active than the homogeneous tetrasulfo derivative prepared via the condensation of sulfophthalic acid. In vivo , the latter dye was completely inactive, whereas the remainder of the sulfonated preparations exhibited a similar structure-activity pattern as observed with theV–79 cells in vitro . The disulfonated zinc phthalocyanine showed the best tumoricidal activity in the series and also appeared to be a more efficient photosensitizer of cell inactivation and tumor cure than the aluminum or gallium complexes as well as hematoporphyrin derivative preparations. No significant differences in skin phototoxicity were observed among the various dyes. 相似文献
7.
Several phthalocyanine dimers, trimers, and oligomers bridged via aryl (phenyl) groups were prepared using the Suzuki–Miyaura cross coupling reaction of phthalocyanine-boronate ester and various halide derivatives under palladium catalyst reaction conditions. Photophysical data reveal energy transfer between the Pc moieties resulting in the appearance of new red-shifted Q-bands. The shift and the nature of Q-band depend on the number of phenyl groups, the number of Pc, and the position of attachment on the phenyl ring. 相似文献
8.
Palladium-catalyzed copper-free Sonogashira cross-coupling reactions were performed on a protected and unprotected monoiodotriglycerol substituted Zn(II) phthalocyanine with various alkynes in organic and aqueous medium. From the silyl protected alkyne derivative, a protected homo coupled dimeric product was also prepared using Glaser coupling. All products were purified by reverse phase HPLC and the assigned structures were confirmed by mass and UV-vis spectroscopy. 相似文献
9.
Hasrat AliJohan E. van Lier 《Tetrahedron letters》2012,53(36):4824-4827
An easy synthetic method for the preparation of pyrazine-2,3-dicarbonitrile 5,6-bis-substituted derivatives using Pd-catalyzed cross coupling reaction (Sonogashira, Suzuki, Heck) is described. The reaction conditions allow preparing symmetrical and unsymmetrical bis-substituted products in moderate to high yields, as precursors for the preparation of highly substituted symmetrical and non-symmetrical aza-phthalocyanines with well-defined spectral properties. 相似文献
10.