Hydrometallation of 1-alkyl-3-trifluoromethyl propargyl alcohols

The hydrometallation of trifluoromethylated propargyl alcohol derivatives with metal hydride reagents proceeds smoothly to give cis- and trans-olefins on H₂O quenching. The halodemetallation of intermediate formed in the reaction process was also examined.     

Preparation of 19,19,19-trifluororetinal(9-trifluoromethylretinal)

Synthetic work of all-trans-19,19,19-trifluororetinal (7E,9Z,11E,13E) is described.     

Novel one-pot approach to synthesis of indanones through Sb(V)-catalyzed reaction of phenylalkynes with aldehydes

Catalytic SbF5 and the use of EtOH as an additive efficiently converted a mixture of phenylalkynes and aldehydes to indanone compounds in one pot, and the reaction stereoselectively afforded the corresponding 2,3-disubstituted indanones as a single trans-isomer.     

Substoichiometric determination of uranium in phosphate rock

The substoichiometric isotope dilution analysis for U(VI) in a synergic extraction system of an excess amount of a chelating agent HHFA and a substoichiometric amount of neutral ligand TOPO has been developed. A constant but substoichiometric amout of U(VI) can be precisely extracted, and U down to ppm levels can be accurately determined by the present method. This method was applied to the analysis of a phosphate rock.     

Copper-catalyzed allylations of zirconocene intermediates generated from o-alkenyl or o-alkynylbenzyl ether derivatives and zirconocene-butene complex

o-Alkenyl or alkynyl benzylzirconocene intermediate, which was readily generated by the reaction of 2-alkoxymethylstyrene or 2-alkoxymethyl-1-(trimethylsilylethynyl)-benzene derivative with zirconocene-butene complex (Negishi reagent, "Cp2Zr"), reacted with allyl or propargyl halides in the presence of a catalytic amount of CuCl to give allylation or allenylation products. Conversion to Dane's diene, which is a key intermediate for estrone synthesis, was efficiently carried out by enyne olefin metathesis of the allylation products.