Imide and anhydride bridged organoiron dinuclear homo and hetero dichalcogeno carboxylate complexes [CpFe(CO)2ECO(C6H4)CO]2NH and [CpFe(CO)2ECO(C6H4)CO]2O; E = S,Se

Organoiron thio- and seleno-terephthaloyl chloride complexes CpFe(CO)₂ECO(C₆H₄)COCl (E = S and Se) react with NaOH and NaNH₂ to give quantitative yields of the acid Cp(CO)₂ECO(C₆H₄)CO₂H and the amide CpFe(CO)₂ECO(C₆H₄)CONH₂ respectively. These amide and acid derivatives react with the terephthaloyl chloride complexes to give a new series of imide-bridged [CpFe(CO)₂ECO(C₆H₄)CO]₂NH and anhydride-bridged [CpFe(CO)₂ECO(C₆H₄)CO]₂O organoiron dinuclear homo and hetero dichalcogeno terephthalate complexes. The complexes were characterized by elemental analysis, i.r. and ¹H-n.m.r. spectra. This revised version was published online in June 2006 with corrections to the Cover Date.     

Synthesis and biological study of a new series of bifunctional organoiron thio‐ and seleno‐terephthalate derivatives (C5H5)Fe(CO)2ECO(C6H4)COX (E = S,X = R2N,RNH, NH2, OH,Cl; E = Se,X = RNH,RS, RCOO,NH2, OH,Cl)

A new series of bifunctional organoiron thio‐ and seleno‐terephthalate complexes — (η‐C₅H₅)Fe(CO)₂ECO(C₆H₄)COX [E = S; X = C₆H₁₁NH, (C₂H₅)₂N; and E = Se; X = P? CH₃? C₆H₄? NH, C₆H₅? C₂N₂O? S, m? NO₂? C₆H₄? CH?CH? COO] — has been synthesized via the organic transformation reactions of the terephthaloyl chloride precursors η‐(C₅H₅)Fe(CO)₂ECO(C₆H₄)COCl with the desired nucleophiles. These new complexes were characterized by elemental analysis, IR and ¹H NMR spectra. The above complexes, in addition to some other selected analogues, were tested for their antifungal, antibacterial and mutagenic activity. Our results show that all the selenium‐containing compounds have antifungal activity on Candida albicans and antibacterial effects against Bacillus subtilis and Staphylococcus aureus. Four of the six selenium‐containing derivatives exhibited growth inhibitory effects against Pseudomonas aeruginosa and/or Escherichia coli. Sulfur‐containing derivatives elicited activity against C. albicans, and each one of them showed activity against at least one of the bacterial strains that have been used in this investigation. Two selenium‐ and two sulfur‐containing derivatives showed mutagenic activity against one or more than one strain of the Salmonella typhimurium using the Ames test. Copyright © 2001 John Wiley & Sons, Ltd.