Protein and solvent dynamics: how strongly are they coupled?

Analysis of Raman and neutron scattering spectra of lysozyme demonstrates that the protein dynamics follow the dynamics of the solvents glycerol and trehalose over the entire temperature range measured 100-350 K. The protein's fast conformational fluctuations and low-frequency vibrations and their temperature variations are very sensitive to behavior of the solvents. Our results give insight into previous counterintuitive observations that protein relaxation is stronger in solid trehalose than in liquid glycerol. They also provide insight into the effectiveness of glycerol as a biological cryopreservant.     

Benzotriazole derivatives as long wavelength photosensitizers for diaryliodonium salt initiators

Two benzotriazole derivative dyes 4,7‐bis(2,3‐dihydrothieno[3,4‐b][1,4]dioxin‐5‐yl)‐2‐dodecyl‐2H‐benzo[1,2,3]triazole, and 2‐dodecyl‐4,7‐bis(4‐hexylthiophen‐2‐yl)‐2H‐benzo[d][1,2,3]triazole are shown to work as efficient photosensitizers for a diphenyliodonium salt initiator in cationic photopolymerization of epoxide and vinyl monomers. Substituted thienyl groups are attached to benzotriazole backbone to extend conjugation and enhance electron density of the molecules. Thereby, it was possible to initiate polymerizations at room temperature using long wavelength UV and visible light. The progress of photopolymerizations was monitored using optical pyrometry. The photopolymerization of an epoxide monomer using solar irradiation was also demonstrated. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011     

Pediatric abdominal masses: diagnostic accuracy of diffusion weighted MRI

Purpose

To retrospectively identify apparent diffusion coefficient (ADC) values of pediatric abdominal mass lesions, to determine whether measured ADC of the lesions and signal intensity on diffusion-weighted (DW) images allow discrimination between benign and malignant mass lesions.

Materials and Methods

Approval for this retrospective study was obtained from the institutional review board. Children with abdominal mass lesions, who were examined by DW magnetic resonance imaging (MRI) were included in this study. DW MR images were obtained in the axial plane by using a non breath-hold single-shot spin-echo sequence on a 1.5-T MR scanner. ADCs were calculated for each lesion. ADC values were compared with Mann–Whitney U test. Receiver operating characteristic curve analysis was performed to determine cut-off values for ADC. The results of visual assessment on b800 images and ADC map images were compared with chi-square test.

Results

Thirty-one abdominal mass lesions (16 benign, 15 malignant) in 26 patients (15 girls, 11 boys, ranging from 2 days to 17 years with 6.9 years mean) underwent MRI. Benign lesions had significantly higher ADC values than malignant ones (P<.001). The mean ADCs of malignant lesions were 0.84±1.7×10⁻³ mm²/s, while the mean ADCs of the benign ones were 2.28±1.00×10⁻³ mm²/s. With respect to cutoff values of ADC: 1.11×10⁻³ mm²/s, sensitivity and negative predictive values were 100%, specificity was 78.6% and positive predictive value was 83.3%. For b800 and ADC map images, there were statistically significant differences on visual assessment. All malignant lesions had variable degrees of high signal intensity whereas eight of the 16 benign ones had low signal intensities on b800 images (P<.001). On ADC map images, all malignant lesions were hypointense and most of the benign ones (n=11, 68.7%) were hyperintense (P<.001).

Conclusion

DW imaging can be used for reliable discrimination of benign and malignant pediatric abdominal mass lesions based on considerable differences in the ADC values and signal intensity changes.     

Subplanes of projective planes of order 121

We determine orbit representatives of all proper subplanes generated by quadrangles of a Veblen-Wedderburn (VW) plane Π of order 11² and the Hughes plane Σ of order 11² under their full collineation groups. In Π, there are 13 orbits of Baer subplanes all of which are desarguesian and approximately 3000 orbits of Fano subplanes. In Σ, there are 8 orbits of Baer subplanes all of which are desarguesian, 2 orbits of subplanes of order 3 and at most 408,075 distinct Fano subplanes. This work was motivated by the well-known question: “Does there exist a non-desarguesian projective plane of prime order?” The question remains unsettled.     

Supercapacitor study of reduced graphene oxide/Zn nanoparticle/polycarbazole electrode active materials and equivalent circuit models

Journal of Solid State Electrochemistry - In this study, graphene oxide (GO) was chemically reacted with sodium borohydride (NaBH4) to form reduced graphene oxide (rGO). rGO and rGO/Zn...     

Efficient and robust scale estimation for trended time series

This paper presents a new method for robust online variability extraction in time series. The proposed estimator is simultaneously highly robust and efficient. We derive its breakdown point, influence function, and asymptotic variance and study the finite sample properties in a simulation study.     

A Facile Synthesis of Various Butenolides

The synthesis of α'-acyloxy-α,β-unsaturated cyclic ketones from the corresponding α,β-unsaturated cyclic ketones by using manganese (III) acetate in combination with 2-chloropropionic acid followed by subsequent Arbuzov and intramolecular Horner-Emmons cyclization reactions provided a convenient synthetic pathway to various butenolides 4a-d.     

The Exchange Variations of Offset Curves and Surfaces

Results in Mathematics - This paper proposes a novel definition of generalized and standard offset curves and surfaces that was inspired by the needs in many engineering design practices. We also...     

Partitioning 3‐arcs into Steiner Triple Systems

In this article, it is shown that there is a partitioning of the set of 3‐arcs in a projective plane of order three into nine pairwise disjoint Steiner triple systems of order 13.     

Customer rebates and retailer incentives in the presence of competition and price discrimination

Promotions are important tools for matching supply and demand in many industries. In the United States automotive industry, promotions are frequently offered, which may be given directly to customers (rebates) or given to dealers (incentives) to stimulate demand. We analyze the performance of customer rebate and retailer incentive promotions under competition. We study a setting with two manufacturers making simultaneous pricing and promotion decisions, and with two price-discriminating retailers as Stackelberg followers making simultaneous order quantity decisions. In the benchmark case with no promotions, we characterize the equilibria in closed form. We find that retailer incentives can be used by manufacturers to simultaneously improve each of their profits but can potentially lead to lower retailer profits. When manufacturers use customer rebates, we show that a manufacturer is able to decrease the profit of her competitor while increasing her own profit, although she is also at risk for her competitor to use rebates in a similar fashion. Unlike the monopoly case where the manufacturers are always better off with retailer incentives, customer rebates can be more profitable under some cases in the presence of competition. Using numerical examples we generate insights on the manufacturers’ preference of promotions in different market settings.