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1.
Nourallah Hazeri Malek Taher Maghsoodlou Sayyed Mostafa Habibi‐Khorassani Jasem Aboonajmi Seyed Sajad Sajadikhah 《中国化学会会志》2013,60(4):355-358
Fe(NO3)3·9H2O is used as an efficient and effective catalyst for the one‐pot three‐component synthesis of highly functionalized piperidines from aromatic aldehydes, anilines and b–ketoesters in ethanol at ambient temperature. This procedure includes some important aspects like the easy work‐up, no need to column chromatography, simple and readily available precursors, and good to high yields. 相似文献
2.
Milan Jasem 《Mathematica Slovaca》2011,61(5):827-833
Let A = (A,⊕,−,∼, 0, 1) be a GMV-algebra and ρ: A × A → A the distance function on A defined by ρ(x, y) = (x∨y)−(x∧y) for each x, y ∈ A. 相似文献
3.
Hadeer Darwish Sarah Alharthi Radwa A. Mehanna Samar S. Ibrahim Mustafa A. Fawzy Saqer S. Alotaibi Sarah M. Albogami Bander Albogami Sedky H. A. Hassan Ahmed Noureldeen 《Molecules (Basel, Switzerland)》2022,27(19)
Chemotherapy is an aggressive form of chemical drug therapy aiming to destroy cancer cells. Adjuvant therapy may reduce hazards of chemotherapy and help in destroying these cells when obtained from natural products, such as medical plants. In this study, the potential therapeutic effect of Rosa damascena callus crude extract produced in vitamin-enhanced media is investigated on colorectal cancer cell line Caco-2. Two elicitors, i.e., L-ascorbic acid and citric acid at a concentration of 0.5 g/L were added to the callus induction medium. Callus extraction and the GC–MS analysis of methanolic crude extracts were also determined. Cytotoxicity, clonogenicity, proliferation and migration of Caco-2 colorectal cancer cells were investigated using MTT cytotoxicity, colony-forming, Ki-67 flow cytometry proliferation and Migration Scratch assays, respectively. Our results indicated that L-ascorbic acid treatment enhanced callus growth parameters and improved secondary metabolite contents. It showed the least IC50 value of 137 ug/mL compared to 237 ug/mL and 180 ug/mL in the citric acid-treated and control group. We can conclude that R. damascena callus elicited by L-ascorbic acid improved growth and secondary metabolite contents as well as having an efficient antiproliferative, anti-clonogenic and anti-migratory effect on Caco-2 cancer cells, thus, can be used as an adjuvant anti-cancer therapy. 相似文献
4.
Roeland Vanhoutte Marta Barniol-Xicota Winston Chiu Laura Vangeel Dirk Jochmans Steven De Jonghe Hadeer Zidane Haim M. Barr Nir London Johan Neyts Steven H. L. Verhelst 《Chemical science》2023,14(7):1666
The COVID-19 pandemic has revealed the vulnerability of the modern, global society. With expected waves of future infections by SARS-CoV-2, treatment options for infected individuals will be crucial in order to decrease mortality and hospitalizations. The SARS-CoV-2 main protease is a validated drug target, for which the first inhibitor has been approved for use in patients. To facilitate future work on this drug target, we designed a solid-phase synthesis route towards azapeptide activity-based probes that are capped with a cysteine-reactive electrophile for covalent modification of the active site of Mpro. This design led to the most potent ABP for Mpro and one of the most potent inhibitors reported thus far. We demonstrate that this ABP can be used to visualize Mpro activity and target engagement by drugs in infected cells.The COVID-19 pandemic has revealed the vulnerability of the modern, global society. 相似文献
5.
Wafaa S. Hamama Mona E. Ibrahim Hadeer A. Raoof Hanafi H. Zoorob 《Research on Chemical Intermediates》2017,43(11):6259-6291
This review provides a survey of the advances in the methods of formation and chemical reactivity of bicyclic [1,3,4]thiadiazole 5-5 systems containing ring-junction nitrogen over the period from 1989 to the beginning of 2017. 相似文献
6.
Hashem Sharghi Jasem Aboonajmi Mahdi Aberi Pezhman Shiri 《Journal of the Iranian Chemical Society》2018,15(5):1107-1118
7.
Application and developing of iron‐doped multi‐walled carbon nanotubes (Fe/MWCNTs) as an efficient and reusable heterogeneous nanocatalyst in the synthesis of heterocyclic compounds 下载免费PDF全文
Hashem Sharghi Jasem Aboonajmi Mozhdeh Mozaffari Mohammad Mahdi Doroodmand Mahdi Aberi 《应用有机金属化学》2018,32(3)
Iron‐doped multi‐walled carbon nanotubes (Fe/MWCNTs) is an efficient, ecofriendly and reusable heterogeneous nanocatalyst for the one‐pot synthesis of heterocyclic compounds including bis‐spiro piperidines, piperidines, dihydro‐2‐oxopyrroles, pyrazoles and diazepines at room temperature with good to excellent yields. The heterogeneous nanocatalyst was fully characterized by scanning electron microscopy (SEM), X‐ray diffraction (XRD), inductively coupled plasma (ICP) and FT‐IR analysis. Also, the structures of all prepared compounds were characterized by 1H NMR, 13C NMR, FT‐IR, mass spectrometry (MS) and elemental analysis. The major advantages of these protocols are mild and green reaction conditions, short reaction times, clean reaction, operational simplicity, easy purification and good to excellent yields with the reusable heterogeneous nanocatalyst. The catalyst was ten recycled without significant loss of activity. 相似文献
8.
Hadeer Jasem Angham G. Hadi Gamal A. El-Hiti Mohammed A. Baashen Hassan Hashim Ahmed A. Ahmed Dina S. Ahmed Emad Yousif 《Molecules (Basel, Switzerland)》2021,26(12)
Poly(vinyl chloride) degrades when exposed to ultraviolet light for long durations; therefore, the photostability of polymeric materials should be enhanced through the application of additives. New organotin complexes containing 4-aminonaphthalene-1-sulfonic acid were synthesized and their role as poly(vinyl chloride) photostabilizers were evaluated. The reaction of 4-amino-3-hydroxynaphthalene-1-sulfonic acid and appropriate di- or trisubstituted tin chloride (triphenyltin chloride, tributyltin chloride, dibutyltin dichloride, and dimethyltin dichloride) in methanol under reflux gave the corresponding tin-naphthalene complexes with yields of 75%–95%. Elemental analyses and spectroscopic techniques including infrared and nuclear magnetic resonance (proton and tin) were used to confirm their structures. The tin complexes were added to poly(vinyl chloride) to produce thin films that irradiated with ultraviolet light. Various parameters were assessed, such as the weight loss, formation of specific functional groups, changes in the surface due to photoirradiation, and rate constant of photodegradation, to test the role played by the organotin complexes to reduce photodegradation in polymeric films. The results proved that organotin complexes acted as photostabilizers in these circumstances. The weight loss, formation of fragments containing specific functional groups, and undesirable changes in the surface of polymeric films were limited in the presence of organotin complexes. Organotin complexes containing three phenyl groups showed the most desirable stabilization effect. These act as efficient primary and secondary photostabilizers, and as decomposers for peroxides. In addition, such an additive inhibits the dehydrochlorination process, which is the main cause of poly(vinyl chloride) photodegradation. 相似文献
9.
Milan Jasem 《Mathematica Slovaca》2007,57(2):107-118
In the paper isometries in pseudo MV-algebras are investigated. It is shown that for every isometry f in a pseudo MV-algebra
= (A, ⊕, −, ∼, 0, 1) there exists an internal direct decomposition
of
with
commutative such that
and
for each x ∈ A.
On the other hand, if
is an internal direct decomposition of a pseudo MV-algebra
= (A, ⊕, −, ∼, 0, 1) with
commutative, then the mapping g: A → A defined by
is an isometry in
and
.
相似文献
10.