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1.
Background
Major depression is a serious mood disorder affecting millions of adults and children worldwide. While the etiopathology of depression remains obscure, antidepressant medications increase synaptic levels of monoamine neurotransmitters in brain regions associated with the disease. Monoamine transmitters activate multiple signaling cascades some of which have been investigated as potential mediators of depression or antidepressant drug action. However, the diacylglycerol arm of phosphoinositide signaling cascades has not been systematically investigated, even though downstream targets of this cascade have been implicated in depression. With the ultimate goal of uncovering the primary postsynaptic actions that may initiate cellular antidepressive signaling, we have examined the antidepressant-induced production of CDP-diacylglycerol which is both a product of diacylglycerol phosphorylation and a precursor for the synthesis of physiologically critical glycerophospholipids such as the phosphatidylinositides. For this, drug effects on [3H]cytidine-labeled CDP-diacylglycerol and [3H]inositol-labeled phosphatidylinositides were measured in response to the tricyclics desipramine and imipramine, the selective serotonin reuptake inhibitors fluoxetine and paroxetine, the atypical antidepressants maprotiline and nomifensine, and several monoamine oxidase inhibitors. 相似文献2.
Dalila Boughaci Belaïd Benhamou Habiba Drias 《Journal of Mathematical Modelling and Algorithms》2008,7(2):101-124
In this paper, both scatter search (SS) and genetic algorithms (GAs) are studied for the NP-Hard optimization variant of the satisfiability problem, namely MAX-SAT. First, we investigate a new selection strategy based on both fitness and diversity to choose individuals to participate in the reproduction phase of a genetic algorithm. The resulting algorithm is enhanced in two ways leading to two genetic algorithm variants: the first one uses a uniform crossover. The second one uses a specific crossover operator (to MAX-SAT). The crossover operator is combined with an improved stochastic local search (SLS). The crossover operator is used to identify promising regions while the stochastic local search performs an intensified search of solutions around these regions. Secondly, we propose a scatter search variant for MAX-SAT. Both the SS and the GAs implementations share the solution selection strategy, the improved SLS method and the combination operator. Experiments on several instances from MAX-SAT libraries are performed to show and compare the effectiveness of our approaches. The computational experiments show that both (SS) and (GAs) with a stochastic local search (SLS) improvement technique outperform a classical genetic algorithm (without SLS). The two metaheuristics are able of balancing search diversification and intensification which leads to good results. In general, the specific genetic algorithm with a (SLS) improvement technique and a specific combination method provides competitive results and finds solutions of a higher quality than a scatter search. 相似文献
3.
Daroui-Mokaddem H Kabouche A Bouacha M Soumati B El-Azzouny A Bruneau C Kabouche Z 《Natural product communications》2010,5(10):1669-1672
The essential oils of fresh leaves of Eucalyptus globulus L. (Myrtaceae), and leaves and stems of Smyrnium olusatrum L. (Apiaceae), obtained by hydrodistillation in a Clevenger-type apparatus, were analyzed by GC/MS. Twenty compounds were characterized, representing 98.3% of the essential oil of E. globulus, with 1,8-cineole (48.6%), globulol (10.9%), trans-pinocarveol (10.7%), and alpha-terpineol (6.6%) as main components, while thirty-three compounds were characterized, representing 94.3% of the essential oil of S. olusatrum, with sabinene (27.1%), curzerene (13.7%), methyl-1-benzyl-2-oxocyclooctane carboxylate (12.3%), alpha-pinene (7.2%), cryptone (7.1%) and beta-pinene (5.7%) as the major components. The essential oils of E. globulus and S. olusatrum were tested against a wide range of fungal and bacterial strains. Both oils showed significant antimicrobial activity. 相似文献
4.
Youssef Ait Ahmed Ahmed Tirbiyine Ahmed Taoufik Hassan El Ouaddi Habiba El Hamidi Abdelhalim Hafid 《Phase Transitions》2013,86(11):1093-1099
ABSTRACTWe have studied the reversible and irreversible part of the hysteresis loops as a function of slow cooling rate through the order–disorder transformation near 80?K for the deuterated (κ-D8-Br) κ-(BEDT-TTF)2Cu[N(CN)2]Br organic superconductor. We estimated the critical current density JC and the thermodynamic critical field HC from the magnetic hysteresis loops. Temperature dependence of the critical current density derived from the irreversible part using Bean’s model. The thermodynamic critical field HC has been obtained from the reversible part of the hysteresis loops. 相似文献
5.
Nina M Fonné-Pfister R Beaudegnies R Chekatt H Jung PM Murphy-Kessabi F De Mesmaeker A Wendeborn S 《Journal of the American Chemical Society》2005,127(16):6027-6038
Thermodynamic and structural properties of a chemically modified DNA-RNA hybrid in which a phosphodiester linkage is replaced by a neutral amide-3 linkage (3'-CH(2)-CONH-5') were investigated using UV melting experiments, molecular dynamics simulations in explicit water, and continuum solvent models. van't Hoff analysis of the experimental UV melting curves suggests that the significant increase of the thermodynamic stability of a 15-mer DNA-RNA with seven alternated amide-3 modifications (+11 degrees C) is mainly due to an increased binding enthalpy. To further evaluate the origin in the observed affinities differences, the electrostatic contribution to the binding free energy was calculated by solving the Poisson-Boltzmann equation numerically. The nonelectrostatic contribution was estimated as the product of a hydrophobic surface tension coefficient and the surface area that is buried upon double strand formation. Structures were taken from 10 ns molecular dynamics simulations computed in a consistent fashion using explicit solvent, counterions, and the particle-mesh Ewald procedure. The present preliminary thermodynamic study suggests that the favorable binding free energy of the amide-3 DNA single strand to the complementary RNA is equally driven by electrostatic and nonpolar contributions to the binding compared to their natural analogues. In addition, molecular dynamics simulations in explicit water were performed on an amide-3 DNA single strand and the corresponding natural DNA. Results from the conformations cluster analysis of the simulated amide-3 DNA single strand ensembles suggest that the 25% of the population sampled within 10 ns has a pre-organized conformation where the sugar C3' endo pucker is favored at the 3'-flanking nucleotides. These structural and thermodynamic features contribute to the understanding of the observed increased affinities of the amide-3 DNA-RNA hybrids at the microscopic level. 相似文献
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7.
In this review article the synthesis of iron chalcogenides using single source precursors is discussed. The effect on morphology and phase of iron chalcogenides formed is studied by varying single source precursors, reaction temperature, reaction time, surfactants and their concentration. Copyright © 2016 John Wiley & Sons, Ltd. 相似文献
8.
M Hessien P Léone M Suchaud B Lebeau H Nouali Y Guari E Prouzet 《Chemical communications (Cambridge, England)》2012,48(80):10022-10024
PIC (Phase Inversion Composition) O-W nanoemulsions was used as a template for the synthesis of Hierarchical Porous Silica (HPS), and the oil phase of the nanoemulsion was used as a nanoreactor for the preparation of magnetic gamma-Fe(2)O(3) nanoparticles, confined within the silica matrix. 相似文献
9.
Following the work of G. Citti and F. Uguzzoni who studied Yamabe type problems on Heisenberg group domains, we consider here the following critical semi-linear equation on domains of the Heisenberg group ${{\mathbb{H}^1}}$ : $$(P) \left\{\begin{array}{lll}-{\Delta_{H}}u\quad =\quad K{u^{3}}\quad\,{\rm in}\,\,\Omega,\\ \quad\quad\,{u}\quad > \quad0\qquad\,\,\,\,{\rm in}\,\,\Omega,\\ \quad\quad\,{u}\quad = \quad 0 \quad\quad\,\,\,{\rm on}\,\partial \Omega, \end{array}\right. $$ where Δ H is the sublaplacian on ${{\mathbb{H}^1}}$ and K is a C 3 positive function defined on Ω. Using a version of the Morse Lemma at infinity, we give necessary conditions on K to insure the existence of solutions for (P). 相似文献
10.
Zakaria Tahraoui Habiba Nouali Claire Marichal Patrice Forler Julien Klein T. Jean Daou 《Molecules (Basel, Switzerland)》2021,26(16)
The influence of the charge compensating cation nature (Na+, Mg2+) on the water adsorption properties of LTA-type zeolites used as filler in composite materials (zeolite/polymers) was investigated. Large scale cation exchanges were performed on zeolite powder at 80 °C for 2 h using 1 M magnesium chloride (MgCl2) aqueous solutions. XRF, ICP, and EDX analyses indicate a successful cationic exchange process without the modification of the zeolite structure as shown by XRD and solid-state NMR analyses. Composite materials (granulates and molded parts) were manufactured using to extrusion and injection processes. In the case of MgA zeolite, nitrogen adsorption–desorption experiments allowed us to measure a microporous volume, unlike NaA zeolite, which is non-porous to nitrogen probe molecule. SEM and EDX analyses highlighted the homogeneous distribution of zeolite crystals into the polymer matrix. Water adsorption capacities confirmed that the trends observed in the zeolite powder samples are preserved after dragging zeolites into composite formulations. Granulates and molded parts composite samples containing the magnesium exchanged zeolite showed an increase of their water adsorption capacity up to +27% in comparison to composite samples containing the non-exchanged zeolite. The MgA composite is more promising for water decontamination applications due to its higher water adsorption properties than the NaA composite. 相似文献