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Abdellatif Bouazzaoui Ahmed A. H. Abdellatif Faisal A. Al-Allaf Neda M. Bogari Mohiuddin M. Taher Mohammad Athar Thomas Schubert Turki M. Habeebullah Sameer H. Qari 《Molecules (Basel, Switzerland)》2021,26(14)
Systemic steroids are used to treat acute graft-versus-host disease (aGVHD) caused by allogenic bone marrow transplantation (allo-BMT); however, their prolonged use results in complications. Hence, new agents for treating aGVHD are required. Recently, a new compound A (CpdA), with anti-inflammatory activity and reduced side effects compared to steroids, has been identified. Here, we aimed to determine whether CpdA can improve the outcome of aGVHD when administered after transplantation in a mouse model (C57BL/6 in B6D2F1). After conditioning with 9Gy total body irradiation, mice were infused with bone marrow (BM) cells and splenocytes from either syngeneic (B6D2F1) or allogeneic (C57BL/6) donors. The animals were subsequently treated (3 days/week) with 7.5 mg/kg CpdA from day +15 to day +28; the controls received 0.9% NaCl. Thereafter, the incidence and severity of aGVHD in aGVHD target organs were analyzed. Survival and clinical scores did not differ significantly; however, CpdA-treated animals showed high cell infiltration in the target organs. In bulk mixed lymphocyte reactions, CpdA treatment reduced the cell proliferation and expression of inflammatory cytokines and chemokines compared to controls, whereas levels of TNF, IL-23, chemokines, and chemokine receptors increased. CpdA significantly reduced proliferation in vitro but increased T cell infiltration in target organs. 相似文献
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Morad Moataz Habeebullah Turki M. Althagafi Ismail Asghar Basim H. Bayazeed Abrar A. Bawazeer Tahani M. Al-Solimy Amerah M. El-Metwaly Nashwa 《Research on Chemical Intermediates》2020,46(10):4543-4562
Research on Chemical Intermediates - Novel copper complexes were prepared from acetanilide derivatives and deliberately characterized. The molar ratio obtained was 1:1 through neutral bi-dentate... 相似文献
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Reem Shah Turki M. Habeebullah Fawaz Saad Ismail Althagafi Aisha Y. Al-dawood Amerah M. Al-Solimy Zehba A. Al-Ahmed Fatimah Al-Zahrani Thoraya A. Farghaly Nashwa El-Metwaly 《应用有机金属化学》2020,34(10):e5886
Five new nitrogen-rich ligands (thioanhydrides) were synthesized and fully characterized. Then, their corresponding Co(II) complexes were prepared and also elucidated by analytical and spectral conformational techniques. First of all, the mono-negative tri-dentate mode was proposed with all derivatives towards mono-nuclear central atom. According to ligand field transitions and magnetic susceptibility values, the square-planar as well as octahedral geometries were the forms suggested. The presence of water molecules was investigated thermally. For conformational implementation under optimal conditions, energy minimization was carried out and fundamental data were obtained and studied. In silico investigation was carried out using the MOE docking approach to predict the inhibition activity for the new compounds. The Co(II)– 3e complex played an excellent inhibitory role. After that and based on preliminary results, in vitro antitumor screening against MCF-7 cell line was conducted for all Co(II) complexes. The results were consistent with that for standard drug (doxorubicin), and the inhibition feature for the complexes was ranked. Through photographic monitoring, outstanding inhibition activity towards breast cancer spreading was recorded for the Co(II)– 3e complex, which coincides well with MOE docking data. 相似文献
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l-Proline-based cyclic dipeptides were synthesized from N-Boc-protected dipeptide methyl esters under catalyst-free condition using water as a solvent. One-pot deprotection and cyclization have been used as the key steps, providing an efficient and environmentally friendly approach. Clean reaction conditions, easy isolation, and good yields of cyclic dipeptides are the salient features of the proposed methodology. 相似文献
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