排序方式: 共有6条查询结果,搜索用时 15 毫秒
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Joseph H. Chan David P. Baccanari Robert L. Tansik Christine M. Boytos Sharon K. Rudolph Andrew D. Brown Jean S. Hong Lee F. Kuyper Michael L. Jones 《Journal of heterocyclic chemistry》1997,34(1):145-151
A series of novel 1,3-diamino-7,8,9,10-tetrahydropyrido[3,2-f]quinazolines were synthesized starting from 6-amino-5-cyanoquinoline (4). These compounds inhibited Candida albicans dihydrofolate reductase with Ki values of ≤0.60 aM. One analogue exhibited moderate in vivo efficacy in a C. albicans-infected mouse model. 相似文献
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Michael L. Jones David P. Baccanari Robert L. Tansik Christine M. Boytos Sharon K. Rudolph Lee F. Kuyper 《Journal of heterocyclic chemistry》1999,36(1):145-148
Novel 2,4-diamino-6-methyl-5-ethynylpyrimidines were prepared via palladium catalyzed coupling of 2,4-diamino-5-iodo-6-methyl-pyrimidine with terminal acetylenes. The compounds were inhibitors of dihydrofolate reductase and showed in vitro activity against several species of opportunistic fungi and the protozoan Toxoplasma gondii. 相似文献
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In this article we characterize the regular LA-semihypergroups in terms of -cubic (left, right, two sided, bi, generalized bi, interior, quasi)-hyperideals of LA-semihypergroups. Meanwhile, some illustrative examples are given to show the rationality of the definitions popularized in the present paper. 相似文献
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Gulcihan Gulseren Gulistan Tansik Ruslan Garifullin Ayse B. Tekinay Mustafa O. Guler 《Macromolecular bioscience》2019,19(1)
Dentin phosphoprotein (DPP) is a major component of the dentin matrix playing crucial role in hydroxyapatite deposition during bone mineralization, making it a prime candidate for the design of novel materials for bone and tooth regeneration. The bioactivity of DPP‐derived proteins is controlled by the phosphorylation and dephosphorylation of the serine residues. Here an enzyme‐responsive peptide nanofiber system inducing biomineralization is demonstrated. It closely emulates the structural and functional properties of DPP and facilitates apatite‐like mineral deposition. The DPP‐mimetic peptide molecules self‐assemble through dephosphorylation by alkaline phosphatase (ALP), an enzyme participating in tooth and bone matrix mineralization. Nanofiber network formation is also induced through addition of calcium ions. The gelation process following nanofiber formation produces a mineralized extracellular matrix like material, where scaffold properties and phosphate groups promote mineralization. It is demonstrated that the DPP‐mimetic peptide nanofiber networks can be used for apatite‐like mineral deposition for bone regeneration. 相似文献
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Karadas Ozge Mese Gulistan Ozcivici Engin 《Applied biochemistry and biotechnology》2019,188(2):514-526
Applied Biochemistry and Biotechnology - Carnosol and carnosic acid are polyphenolic compounds found in rosemary and sage with known anti-oxidant, anti-inflammatory, and anti-microbial properties.... 相似文献
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G. Erik Jagdmann Joseph H. Chan Virgil L. Styles Robert L. Tansik Christine M. Boytos Sharon K. Rudolph 《Journal of heterocyclic chemistry》1995,32(5):1461-1465
Several 5-(4-substituted benzyl)-2,4-diaminoquinazolines were prepared as potentially selective inhibitors of Candida albicans dihydrofolate reductase. These compounds were synthesized by a novel route, which included as a key step the displacement of a fluoro group in 2,6-difluorobenzonitrile by the anions of ethyl or methyl 4-substituted phenylacetates. The resultant diarylacetates were saponified and decarboxylated to the 2-fluoro-6-(4-substituted phenyl)benzonitriles. Ring closure of these benzonitriles with guanidine carbonate gave the 5-(4-substituted benzyl)-2,4-diaminoquinazolines. 相似文献
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