排序方式: 共有17条查询结果,搜索用时 15 毫秒
1.
2.
Singh J Kronenthal DR Schwinden M Godfrey JD Fox R Vawter EJ Zhang B Kissick TP Patel B Mneimne O Humora M Papaioannou CG Szymanski W Wong MK Chen CK Heikes JE DiMarco JD Qiu J Deshpande RP Gougoutas JZ Mueller RH 《Organic letters》2003,5(17):3155-3158
[reaction: see text] An efficient asymmetric synthesis of the vasopeptidase inhibitor BMS-189921 was accomplished. Two short enantioselective syntheses of the common key intermediate (S)-alpha-aminoazepinone 6b were developed. Olefin 3 was converted to 6b via asymmetric hydrogenation. Alternatively, enyne 12 was converted to racemic alpha-aminoazepinone 15b, which was transformed to 6b by a practical dynamic resolution. 相似文献
3.
4.
Saleem Ahmad Steven H. Spergel Joel C. Barrish John DiMarco Jack Gougoutas 《Tetrahedron: Asymmetry》1995,6(12):2893-2894
The absolute configuration of (+)-2,3,3-trimethyl-2-hydroxybutanoic acid, a key intermediate in the synthesis of the HIV-protease inhibitor 1a (isomer A), has been confirmed as (R) on the basis of X-ray analysis. 相似文献
5.
6.
Allylation of the C-2 enolate of the bicyclo[3.3.1]nonenedione 1 proceeds with an unusual acyl migration to yield the C-allyl ester 5 of the rearranged bicyclo[4.2.1]nonenedione system. 相似文献
7.
8.
Regueiro-Ren A Leavitt K Kim SH Höfle G Kiffe M Gougoutas JZ DiMarco JD Lee FY Fairchild CR Long BH Vite GD 《Organic letters》2002,4(22):3815-3818
[formula: see text] 3-Cyano epothilones 15-18 are the only examples of non-hydroxy C-3-substituted analogues. Their tubulin binding affinity and cytotoxicity provide meaningful structure-activity relationship information on the dependence of C-1/C-3 conformation upon activity. 12-Cyano epothilone 24 has improved pH stability over epothilone B, and its activity further supports the hypothesis that C-12 stereochemistry is not critical for tubulin affinity. 相似文献
9.
苯二酚异构体的电动毛细管色谱-玻碳微电极柱上安培检测分析方法研究 总被引:5,自引:0,他引:5
在玻碳纤维微电极上研究了电解液中β-环糊精(CD)的浓度对邻、间、对苯二酚的循环伏安特性的影响,从实验结果和分子结构水平方面考察了β-CD与邻、间、对苯二酚的包结作用。研究结果表明,β-CD与邻、间、对苯二酚的包结作用强弱顺序为间苯二酚、邻苯二酚、对苯二酚。讨论了电泳缓冲液中ΝΗ4Cl,SDS,β-CD的浓度及pH值对邻、间、对苯二酚迁移时间的影响。建立了苯二酚异构体胶束电动毛细管色谱-玻碳微电极柱上安培检测分析方法,方法的回收率在98%~103%之间。 相似文献
10.
Aminoacyl adenylate pentacoordinated phosphorus compounds were analyzed by field desorption (FD) and fast atom bombardment (FAB) mass spectrometries, together with the B/E linked scan technique, and their mass spectral fragmentation pathways were investigated. For the five bonds (one P-N bond, three P-O bonds and one mixed anhydride bond P-O-CO), the cleavage usually occurred more on the P-N bond, the mixed anhydride bond and the O-C bond adjacent to the P-O bond, and less on the P-O bond. Ion YH(+), corresponding to water loss from protonated 2',3'-O-isopropylidene-adenosine, was the base peak. The results reflect the structural characteristics of aminoacyl adenylate pentacoordinated phosphorus compounds. Copyright 1999 John Wiley & Sons, Ltd. 相似文献