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2.
Zusammenfassung Es wird die Synthese von 13-Oxo-4-methoxy-13H-benzo[i]-furo[2,3-a]xanthen beschrieben.
Furano compounds XVI
The synthesis of 13-oxo-4-methoxy-13H-benzo[i]furo[2,3-a]-xanthene is recorded.相似文献
3.
Volume changes on mixing of ternary liquid mixtures of N,N-dimethylformamide and diethyl ketone with 1-alkanols have been measured as a function of composition at 303.15 K. The alkanols include 1-propanol, 1-butanol, 1-pentanol and 1-hexanol. The measured VE values are negative in the mixtures of N,N-dimethylformamide, diethyl ketone and 1-propanol, or 1-butanol. The VE data exhibits an inversion in sign in the mixture containing 1-pentanol and positive excess volumes are observed in the mixture containing 1-hexanol. The measured data are compared with predicted values based upon empirical relations. The excess volume for the binary mixture of N,N-dimethylformamide with diethyl ketone has been measured over the entire range of composition at 303.15 K. The VE values are negative for the binary mixture. 相似文献
4.
Dr. Anna Notaro Marta Jakubaszek Severin Koch Dr. Riccardo Rubbiani Dr. Orsolya Dömötör Dr. Éva A. Enyedy Mazzarine Dotou Dr. Fethi Bedioui Mickaël Tharaud Dr. Bruno Goud PD Dr. Stefano Ferrari Prof. Dr. Enzo Alessio Dr. Gilles Gasser 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(22):4997-5009
Cancer is one of the main causes of death worldwide. Chemotherapy, despite its severe side effects, is to date one of the leading strategies against cancer. Metal-based drugs present several potential advantages when compared to organic compounds and they have gained trust from the scientific community after the approval on the market of the drug cisplatin. Recently, we reported the ruthenium complex ([Ru(DIP)2(sq)](PF6) (where DIP is 4,7-diphenyl-1,10-phenantroline and sq is semiquinonate) with a remarkable potential as chemotherapeutic agent against cancer, both in vitro and in vivo. In this work, we analyse a structurally similar compound, namely [Ru(DIP)2(mal)](PF6), carrying the flavour-enhancing agent approved by the FDA, maltol (mal). To possess an FDA approved ligand is crucial for a complex, whose mechanism of action might include ligand exchange. Herein, we describe the synthesis and characterisation of [Ru(DIP)2(mal)](PF6), its stability in solutions and under conditions that resemble the physiological ones, and its in-depth biological investigation. Cytotoxicity tests on different cell lines in 2D model and on HeLa MultiCellular Tumour Spheroids (MCTS) demonstrated that our compound has higher activity than cisplatin, inspiring further tests. [Ru(DIP)2(mal)](PF6) was efficiently internalised by HeLa cells through a passive transport mechanism and severely affected the mitochondrial metabolism. 相似文献
5.
Chen Xiao-Lu Li Xiang-Yu Li Shuai-Shuai Bai Xue Li Tao Goud Erukala Yadaiah Zhong Chong-Min Zuo Ya-Jie 《Russian Journal of General Chemistry》2020,90(11):2163-2169
Russian Journal of General Chemistry - The Grubbs–Hoveyda catalysts have a wide range of applications in catalyzed formation of the carbon-carbon double bonds. In this study, several... 相似文献
6.
B. Shankar Goud Y. Dharmendar Reddy S.R. Mishra M. Ijaz Khan Kamel Guedri Ahmed M. Galal 《印度化学会志》2022,99(8):100618
For this research, an examination on the magnetohydrodynamic flow of a micropolar fluid across a moving vertical porous plate for the presence of thermal radiation is achieved. It is necessary to translate the partial differential equations regulating the flow, heat, & mass transfer into dimensionless form employing proper non-dimensional variables, which are then cracked numerically by utilizing the Finite difference approach. Graphs are used to represent numerical values of various flow profiles; however, tables are used to represent the simulated values of rate coefficients. The velocity rises when the value of Grashof number, dimensionless viscosity ratio is raised, and the opposite effect is seen when the value of magnetic parameter, micro-gyration factor is raised. The result in skin friction coefficient improves when the values of magnetic parameter, micro-gyration factor, Prandtl number, and radiation are raised higher. 相似文献
7.
The aim of this work was to establish optimal conditions for the maximum production of endo-β-1,4 mannanases using cheaper
sources. Eight thermotolerant fungal strains were isolated from garden soil and compost samples collected in and around the
Gulbarga University campus, India. Two strains were selected based on their ability to produce considerable endo-β-1,4 mannanases
activity while growing in liquid medium at 37 °C with locust bean gum (LBG) as the only carbon source. They were identified
as Aspergillus niger gr and Aspergillus flavus gr. The experiment to evaluate the effect of different carbon sources, nitrogen sources, temperatures and initial pH of the
medium on maximal enzyme production was studied. Enzyme productivity was influenced by the type of polysaccharide used as
the carbon source. Copra meal defatted with n-hexane showed to be a better substrate than LBG and guar gum for endo-β-1,4 mannanases production by A. niger gr (40.011 U/ml), but for A. flavus gr (33.532 U/ml), the difference was not significant. Endo-β-1,4 mannanases produced from A. niger gr and A. flavus gr have high optimum temperature (65 and 60 °C) and good thermostability in the absence of any stabilizers (maintaining 50%
of residual activity for 8 and 6 h, respectively, at 60 °C) and are stable over in a wide pH range. These new strains offer
an attractive alternative source of enzymes for the food and feed processing industries. 相似文献
8.
A new bis-andrographolide ether from Andrographis paniculata nees and evaluation of anti-HIV activity 总被引:3,自引:0,他引:3
Reddy VL Reddy SM Ravikanth V Krishnaiah P Goud TV Rao TP Ram TS Gonnade RG Bhadbhade M Venkateswarlu Y 《Natural product research》2005,19(3):223-230
Novel bis-andrographolide ether (1) and six known compounds andrographolide, 14-deoxy-11,12-didehydroandrographolide, andrograpanin, 14-deoxyandrographolide, (+/-)-5-hydroxy-7,8-dimethoxyflavanone, and 5-hydroxy-7,8-dimethoxyflavone have been isolated from the aerial parts of Andrographis paniculata and their structures were established by spectral data. All the isolates were tested for the anti-HIV and cytotoxic activity. 相似文献
9.
H.?HussienEmail author A.?A.?Goud A.?M.?Amin R.?EL-Sheikh U.?Seddik 《Journal of Radioanalytical and Nuclear Chemistry》2011,288(1):9-15
This study describes a fast and efficient method for radiolabeling of etodolac with iodine-125 [125I], where both chloramine-T and iodogen were used as oxidizing agents. The labeling reaction was carried out via electrophilic
substitution of hydrogen atom with the iodonium cation I+. The labeling yield was found to be influenced by different factors such as drug concentration, pH of the reaction mixtures,
different oxidizing agents, reaction time, temperature and different organic media. The radiochemical yield (RCY) was determined
by TLC system using methylene chloride:ethyl acetate (3:7 v/v) as a developing solvent and by electrophoresis using cellulose
acetate moistened with 0.02 M phosphate buffer pH 7. The maximum radiochemical yield of [125I]Etodolac (87.7%) was obtained. Labeled etodolac shows a good localization in inflamed muscle. It excretes mainly via kidney
and to some via liver. 相似文献
10.
K Nagarajan P Madhavan Pillai A Nagana Goud R K Shah 《Proceedings Mathematical Sciences》1977,86(1):25-39
Decomposition of the diazonium chloride from N-(o-aminobenzoyl)-N-methylbenzylamine led to the formation of 3-benzyl-3, 4-dihydrobenzo-triazin-4-one (8), N-benzoylbenzylamine (11), N-benzylphthalimidine (13) ando-diphenic acid N-methyl amide (14), the last one presumably through the intermediary, the expected dibenzazepinone 16. From the analogue, N-(o-aminobenzoyl)-4-methoxybenzyl amine (4), triazinone 10 and N-benzoyl-4-methoxybenzyl amine (12) were obtained. Application of Pschorr reaction to N-(o-aminobenzoyl)-N-methyl-β-(4-methoxyphenyl) ethyl amine (23) afforded 2-methoxy-7-methyl-5, 6, 7, 8- tetrahydrodibenzo (c, e) azocin-8-one (26), with an interesting conformation. From N-(o-aminophenylacetyl)-p-methoxyaniline were obtained under these conditions, indazole-3-carboxylic acidp-anisidide (35) and N-[2-(4-methoxyphenyl carbamoylmethyl) phenyl]-1-(p-methoxyphenyl) isatin-β-hydrazone (37). The structure of 37 was deduced from spectral data and hydrolysis to the acid 42. Diazotisation of N-(o-aminophenylacetyl)-1, 2, 3, 4-tetrahydroquinoline (47) led to the formation of tetrahydroquinoline (49) ando-hydroxyphenyl acetic acid (50) presumably through the salicylamide 48. A similar reaction on N-(o-aminophenylacetyl) tetrahydroisoquinoline (52) gave the benzofurandione hydrazone 55, besides tetrahydroisoquinoline. Oxindole 45 and benzofuranone 56 were likely precursors for 37 and 55 respectively. Salicylamides 5, 7, 24 and 34 were byproducts in the Pschorr reaction. 相似文献