A convergent synthesis of octadeca-2E, 13Z-dienyl acetate, a pheromone component ofSynanthedon tipuliformis C.

A convergent synthesis of octadeca-2E, 13Z-dienyl acetate, a pheromone component ofSynanthedon tipuliformis C., has been developed. The synthesis is based on cross-coupling of 8-iodooct-2E-en-I-ol THP ether with dec-5Z-enyl bromide catalyzed by CuBr. Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1529–1531, August, 1997.     

Rapid synthesis of pomalidomide-conjugates for the development of protein degrader libraries

Current methods for the preparation of heterobifunctional pomalidomide-conjugates rely on methods that are often low yielding and produce intractable byproducts. Herein we describe our strategy for the reliable and succinct preparation of pomalidomide-linkers which is essential to the formation of these conjugates. We present the preparation of 18 pomalidomide-linkers in high yield compared to current literature methods. Our findings show that secondary amines consistently afford greater yields than their primary counterparts, a trend that we were able to exploit in the synthesis of several new pomalidomide homo-dimers in enhanced yields compared to similar literature syntheses. This trend was further utilised to develop the first one-pot synthesis of JQ1-pomalidomide conjugates in yields up to 62%, providing a method that is suited to rapid preparation of conjugate libraries as is frequently required for the development of new protein degraders.

Current methods for the preparation of heterobifunctional pomalidomide-conjugates rely on methods that are often low yielding and produce intractable byproducts. Herein we describe our strategy for the succinct preparation of pomalidomide-linkers.     

Trace Detection of Low Concentrations of Ozone Using a CO<Subscript>2</Subscript> Laser with Automatic Tuning over the Spectrum

A technique of detection of ozone, using a CO₂ laser with rapid automated tuning over 8–10 generation lines in the 9.4–9.6-µm spectral range, has been developed. Its experimental verification has shown a higher accuracy of detecting low concentrations of O₃ in comparison with the traditional technique of differential absorption on two lines (on-line and off-line). Using the technique suggested, the content of ozone in the vicinity of city roads with heavy traffic has been measured.__________Translated from Zhurnal Prikladnoi Spektroskopii, Vol. 72, No. 2, pp. 251–255, March–April, 2005.     

Microwave-assisted scavenging of electrophiles utilizing polymer-supported sequestration reagents. Application to the synthesis of N3-acylated dihydropyrimidine libraries

Different scavenging techniques using polymer-supported sequestration agents are described for the purification steps in the synthesis of N3-acylated dihydropyrimidines. For scavenging both excess anhydride and unwanted byproducts, polystyrene and silica supported diamines, aminomethyl-functionalized SynPhase Lanterns and diethylenetriamine StratoSpheres Plugs are used. In both synthesis and purification microwave flash heating was utilized, reducing reaction times from hours to minutes. These two steps coupled with an efficient solid-phase extraction (SPE) workup allowed the generation of a 28-member library of N3-acylated dihydropyrimidines using anhydrides. Using related protocols a 15-member library of N3-functionalized dihydropyrimidines utilizing acid chlorides as acylating reagents was also obtained.     

New and efficient high Stokes shift fluorescent compounds: unsymmetrically substituted 1,2-bis-(5-phenyloxazol-2-yl)benzenes via microwave-assisted nucleophilic substitution of fluorine

Two new unsymmetric derivatives of 1,2-bis-(5-phenyloxazol-2-yl)benzene (ortho-POPOP) were synthesized via microwave-assisted nucleophilic substitution of fluorine which appears to be significantly more efficient compared with conventional thermal activation. The compounds synthesized are characterized by high fluorescence Stokes shifts (6000-11,000 cm⁻¹) in solvents of various polarity, intermediate-to-high fluorescence quantum yields and lifetimes in the range of several nanoseconds.     

Olefination of aldehydes with tetraalkyl-gem-dialumoalkanes

A new method of cis-olefination, based on the reaction of aldehydes with geminal alumolithium reagents, is proposed.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 5, pp. 1151–1154, May, 1990.     

使用分子量级前躯体制备CuInSe_2及其合金并应应用用于光伏发电(英文)

黄铜矿铜铟硒化合物CuInSe2及其与硫或嫁的合金CuIn(Se,S)2或CuInGa(Se,S)2,即所说的CIGS,已通过20%的实验室规模器件光电转换效率展示了其地面光伏应用的巨大潜力。为了减少初始资金成本,提高材料利用率,科研工作者们已经尝试了许多努力通过非真空制程沉积CIGS。这些制程包括电镀工艺,基于颗粒(浆或纳米颗粒)的制程和基于分子量级前趋体的制程。原则上,分子量级前趋体可以使组分元素达到充分混合,可以最大程度地实现组份在基板不同区域的均一分布。这对于一个复杂的涉及到五个主要元素的化合物系统尤为重要。从这个角度来看,分子前趋体的方法具有大面积均匀沉积铜铟镓硒的巨大潜力。这篇综述将着重讨论使用分子前趋体沉积铜铟镓硒制程的最新发展。     

Reactions of 3-iodolevoglucosenone with sodium derivatives of some CH acids. Chiral cyclopropanes and stable oxetenes

3-Iodolevoglucosenone reacts with the sodium derivative of ethyl cyanoacetate at −60°C to give a tetrasubstituted cyclopropane derivative; similar reactions of the sodium derivatives of ethyl acetoacetate and acetylacetone at −60 °C afford the expected transformed Michael adducts, while at 20 °C,O,C-dialkylated products of the oxetene series are formed. Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp 152–156, January, 1999.