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1.
Plumb RS Stumpf CL Gorenstein MV Castro-Perez JM Dear GJ Anthony M Sweatman BC Connor SC Haselden JN 《Rapid communications in mass spectrometry : RCM》2002,16(20):1991-1996
The application of liquid chromatography/mass spectrometry (LC/MS) followed by principal components analysis (PCA) has been successfully applied to the screening of rat urine following the administration of three candidate pharmaceuticals. With this methodology it was possible to differentiate the control samples from the dosed samples and to identify the components of the mass spectrum responsible for the separation. These data clearly show that LC/MS is a viable alternative, or complementary, technique to proton NMR for metabonomics applications in drug discovery and development. 相似文献
2.
The base catalyzed hydrolysis of 2-phenyl-2-oxo-3-(2,6-dimethylphenyl)-1,3,2-oxazaphospholidine, , and 2-phenyl-2-oxo-3-(2,6-diisopropylphenyl)-1,3,2-oxazaphospholidine, , yields ring opened products involving 95% and 100% P-O cleavage, respectively. 相似文献
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5.
The transverse mass spectra of Omega, J/psi, and psi' in Pb+Pb collisions at 158A GeV are studied within a hydrodynamical model of the quark-gluon-plasma expansion and hadronization. The model reproduces the existing data with the common hadronization parameters: temperature T = T(H) congruent with 170 MeV and average collective transverse velocity v(T) congruent with 0.2. 相似文献
6.
Marek Gaździcki Mark I. Gorenstein Stanislaw Mrówczyński 《The European Physical Journal C - Particles and Fields》1998,5(1):129-133
The pion multiplicity per participating nucleon in central nucleus–nucleus collisions at the energies 2–15 AGeV is significantly smaller than in nucleon–nucleon interactions at the same collision energy. This effect of pion suppression is argued to appear due to the evolution of the system produced at the early stage of heavy–ion collisions towards a local
thermodynamic equilibrium and further isentropic expansion.
Received: 21 July 1997 / Revised version: 12 November 1997 / Published online: 26 February 1998 相似文献
7.
Discrimination of components in atherosclerotic plaques from human carotid endarterectomy specimens by magnetic resonance imaging ex vivo 总被引:3,自引:0,他引:3
Morrisett J Vick W Sharma R Lawrie G Reardon M Ezell E Schwartz J Hunter G Gorenstein D 《Magnetic resonance imaging》2003,21(5):465-474
Specific MRI techniques have been used to determine the dimensional and compositional properties of atherosclerotic lesions in carotid endarterectomy tissues. A quantitative comparison of areas of specific features in typical tissue segments was performed using MR images and histologic images. The mean difference for the measurements by the two methods was 4.5% for the total vessel, 5.3% for the internal carotid artery lumen, and 5.0% for the external carotid lumen. For other less abundant components, the mean difference was 14.2%. For direct characterization, individual tissue components were isolated by microdissection and their T1 and T2 relaxation times measured. Highly calcified areas typically had rather short T1 (452-837 ms) and short T2 (10.4-18.4 ms). In contrast, regions enriched in lipid had much longer T1 (1,380-1,480 ms) and longer T2 (35.3-49.0 ms). Other components such as thrombus had intermediate T1 (1,180 ms) and short T2 (15.4 ms). T2 parametric imaging was used as a complementary approach for segmentation and quantitation of tissue components. In fresh tissue, several different components exhibited different T2 ranges: calcified/solid lipid (13-18 ms). cellular/ECM (9-30 ms), fluid lipid (35-40 ms): fibrous (50-60 ms). These results demonstrate the utility of MRI for identifying and quantifying specific components of atherosclerotic plaque ex vivo, and suggest its value for these measurements in vivo as well. 相似文献
8.
Transparent conductive oxide (TCO) thin films play a significant role in recent optical technologies. Displays of various types, photovoltaic systems, and opto-electronic devices use these films as transparent signal electrodes. They are used as heating surfaces and active control layers. Oxides of TCO materials such as: tin, indium, zinc, cadmium, titanium and the like, exhibit their properties. However, indium oxide and indium oxide doped with tin (ITO) coatings are the most used in this technology.In this work, we present conductive transparent indium oxide thin films which were prepared using a novel triode sputtering method. A pure In2O3 target of 2 in. in diameter was used in a laboratory triode sputtering system. This system provided plane plasma discharge at a relatively low pressure 0.5-5 mTorr of pure argon. The substrate temperature was varied during the experiments from room temperature up to 200 °C. The films were deposited on glass, silicon, and flexible polyimide substrates. The films were characterized for optical and electrical properties and compared with the indium oxide films deposited by magnetron sputtering. 相似文献
9.
The shock stability condition in the relativistic hydrodynamics is found. This criterion is applied to a quark-gluon plasma shock-like hadronization transition. 相似文献
10.
R.A. Ritchie M.I. Gorenstein H.G. Miller 《Zeitschrift fur Physik C Particles and Fields》1997,75(3):535-538
Experimental data for nucleus-nucleus collisions at the CERN SPS suggest that an ideal hadron gas model is unable to account simultaneously (same baryonic chemical potential and temperature at freeze-out) for the strange anti-baryon to baryon ratios and pion abundances. Using a thermodynamically consistent excluded volume model we examine possibilities to account for the observed excess of pions. 相似文献