Novel bio-inspired deep eutectic solvent and graphene functionalized deep eutectic solvent as an efficient flame retardant material for cotton fabric

Cellulose - In this study, a novel bioinspired deep eutectic solvent (DES) was synthesized and functionalized with graphene to prepare G-DES. DES was synthesized in the presence of choline chloride...     

Chiral benzimidazoles and their applications in stereodiscrimination processes

Chiral aspects of benzimidazoles have been over-shadowed for a long time due to the large number of reports on benzimidazoles in the medical field in numerous categories of therapeutic agents. The vigorous research activity in chiral applications of benzimidazole derivatives started after bifunctional benzimidazoles made their appearance especially in the last 2–3 decades. Thus, chiral benzimidazoles form a comparatively young branch of chiral chemistry. The presence of pyridine and pyrrole type of nitrogens along with the fused benzene ring confer on this class of molecules, special properties including useful nucleophilicity, hydrogen bonding ability and a rigid backbone, all of which play decisive roles in proven chiral applications. The present review aims to cover the synthetic routes to access chiral benzimidazoles and their applications in a plethora of chiral fields including enantioselective organocatalysis, metal-based catalysis, asymmetric transformations involving benzimidazole-N-heterocyclic carbenes, kinetic resolution, benzimidazole-based macrocyclic hosts in chiral supramolecular chemistry and other miscellaneous chiral applications.     

Synthesis of substituted esters of imidazoles,oxazoles, thiazoles,and diethyl pyrazine-2,5-dicarboxylate from a common acyclic precursor employing C-formylation strategy

A novel synthetic route to substituted esters of imidazoles, oxazoles, thiazoles, and diethyl pyrazine-2,5-dicarboxylates via C-formylation of glycine ethyl ester hydrochloride is reported. This methodology is simple, robust, and gives good yields of different heterocyclic esters in one or two steps from a common acyclic precursor and is amenable to large scale synthesis.     

Synthesis of novel benzo[h][1,6]naphthyridine derivatives from 4-aminoquinoline and cyclic β-ketoester

This paper describes the synthesis of 2,8-dichloroquinolin-4-amine 4 and 4,5,7-trichloro-3-(2-chloroethyl)-2-methylbenzo[h][1,6]naphthyridine 8 as novel class of building blocks. Also describes the regioselective S_NAr reactions of 2,4,8-trichloroquinoline 2 on C₂ and C₄ positions with azide, similarly S_NAr reactions of benzo[h][1,6]naphthyridine 8 at C₄, C₅ positions, and S_N2 reactions on C₃-(2-chloroethyl) side chain with nucleophiles such as primary aromatic amines, methoxide/ethoxide, and azide at different temperatures.     

Synthesis of 4,4-diphenyl-7-oxodibenzodihydro-1,4-diazepinium salts

Conclusions The salt of a new completely aromatic ammonium cation, namely 4, 4-diphenyl-7-oxodibenzo-1, 4-dihydrodiazepinium iodide, was obtained, the structure of which was confirmed by qualitative tests with silver hydroxide, aqueous NaOH solution, and nitrosylsulfuric acid.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 5, pp. 1096–1101, May, 1973.