Simultaneous Determination of Diclofenac Sodium and Rabeprazole Sodium in Bulk and Pharmaceutical Dosage Form by LC

A simple, selective, rapid, precise and accurate reverse phase high pressure liquid chromatographic method has been developed for the simultaneous estimation of diclofenac sodium and rabeprazole sodium from pharmaceutical formulations. The method was developed using a HiQ SiL C18 (250 mm × 4.6 mm i.d.) column with a mobile phase consisting of methanol:water, (80:20 v/v), at a flow rate of 1.25 mL min⁻¹. Detection was carried out at 284 nm. Indapamide was used as an internal standard. The developed method was validated for linearity, accuracy, precision, limit of detection and limit of quantitation. The proposed method can be used for the estimation of these drugs in combined dosage forms.

     

A general method of obtaining vibrational wavefunctions and Frank-Condon factors at low quantum numbers

A general method of obtaining wavefunctions for empirical diatomic molecular potential functions has been given. Efficacy of the method has been tested by computing Franck-Condon factors for some bands of a new system of SiO using Morse oscillator model and these have been compared with the ones obtained using exact Morse wavefunctions. It is concluded that the method is satisfactory at low quantum numbers.     

Relative vibrational transition probabilities in the (B 3 π g−A 3Σ u + ) system of nitrogen for Hulbert-Hirschfelder oscillator model

Hulbert-Hirschfelder (h-h) potential function has been used to obtain the relative vibrational transition probabilities for the observed bands of the first positive system of nitrogen molecule. The vibrational wavefunctions have been calculated by solving the Schrödinger equation by the method due to Langer, at low vibrational quanta and by thewkb method at high vibrational quanta. It is established that theh-h potential is superior to the often used Morse potential function for the transition under consideration.     

Simultaneous Determination of Diclofenac Sodium and Rabeprazole Sodium in Bulk and Pharmaceutical Dosage Form by LC

A simple, selective, rapid, precise and accurate reverse phase high pressure liquid chromatographic method has been developed for the simultaneous estimation of diclofenac sodium and rabeprazole sodium from pharmaceutical formulations. The method was developed using a HiQ SiL C18 (250 mm × 4.6 mm i.d.) column with a mobile phase consisting of methanol:water, (80:20 v/v), at a flow rate of 1.25 mL min^?1. Detection was carried out at 284 nm. Indapamide was used as an internal standard. The developed method was validated for linearity, accuracy, precision, limit of detection and limit of quantitation. The proposed method can be used for the estimation of these drugs in combined dosage forms.