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Chemistry of Natural Compounds - O- and N-propylamino-derivatives of betulin and betulonic acid oxime and methyl ester were synthesized. Their antitumor activity against a panel of 60 human cancer... 相似文献
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O. B. Flekhter G. V. Giniyatullina F. Z. Galin N. Zh. Baschenko N. S. Makara F. S. Zarudii E. I. Boreko O. V. Savinova N. I. Pavlova Z. A. Starikova G. A. Tolstikov 《Chemistry of Natural Compounds》2005,41(6):706-709
New 20-oxo- and hydroxyimino-derivatives of betulin that exhibit immunotropic and antiviral activities were synthesized.
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Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 582–584, November–December, 2005. 相似文献
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G. V. Giniyatullina O. B. Flekhter I. P. Baikova Z. A. Starikova G. A. Tolstikov 《Chemistry of Natural Compounds》2008,44(5):603-605
A practical method for preparing methyl 3β-amino-3-dexoybetulinate that is based on column chromatographic separation of 3α- and 3β-t-butoxycarbonates and subsequent removal of the protecting group using formic acid is proposed. The structure of methyl 3β-N-(t-butoxycarbonyl)-3-deoxybetulinate was established by an x-ray structure analysis.
Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 488–490, September-October, 2008. 相似文献
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Conclusions The reaction of 4,6-dimethyl-2-pyrimidinyl phosphites with proton-containing nucieophilic reagents is due to the anhydride nature of the Cpry-O-P bond and proceeds with the formation of 4,6-dimethyl-1,2-dihydro-2-pyrimidone and the corresponding P(III) derivatives.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 1, pp. 159–162, January, 1986. 相似文献
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G. V. Giniyatullina O. B. Kazakova E. V. Salimova G. A. Tolstikov 《Chemistry of Natural Compounds》2011,47(1):68-72
Amides of betulonic and oleanonic acids with diethylenetriamine, triethylenetetramine, and spermidine were synthesized. Antitumor
activity in vitro was not found for the conjugate of betulonic acid with diethylenetriamine. 相似文献
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Yu. R. Giniyatullina E. V. Peresypkina A. V. Virovets T. G. Cherkasova E. S. Tatarinova 《Russian Journal of Inorganic Chemistry》2012,57(6):811-814
A new complex [{Cd(?-Cpl)5}2Cr(NCS)6][Cd(?-Cpl)4Cr(NCS)6] was synthesized, and its crystal structure was solved. The complex was studied by chemical analysis and IR spectroscopy. 相似文献
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Irina Smirnova Anastasiya Petrova Gulnara Giniyatullina Anna Smirnova Alexandrina Volobueva Julia Pavlyukova Vladimir Zarubaev Tran Van Loc Thao Tran Thi Phoung Vu Thi Bich Hau Nguyen Thi Thu Thuy Myint Myint Khine Oxana Kazakova 《Molecules (Basel, Switzerland)》2022,27(23)
A series of sixteen A-ring modified (2,3-indolo-, 2-benzylidene) oleanonic acid derivatives, holding some cyclic amines, linear polyamines and benzylaminocarboxamides at C28, has been synthesized and screened for antiviral activity against influenza A/PuertoRico/8/34 (H1N1) and Dengue virus serotypes of DENV-1, -2, -3, -4. It was found that 28-homopiperazine 2 and 3-N-phthalyl 22 amides of oleanonic acid demonstrated high potency with selectivity index SI 27 (IC50 21 μM) and 42 (IC50 12 μM). Oleanonic acid aminoethylpiperazine amide 6 and C-azepano-erythrodiol 23 appeared to be the most effective compounds against DENV-1 (IC50′s 67 and 107 μM) and -2 (IC50′s 86 and 68 μM correspondingly) serotypes. 相似文献