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Thumshirn G Hersel U Goodman SL Kessler H 《Chemistry (Weinheim an der Bergstrasse, Germany)》2003,9(12):2717-2725
The alpha v beta 3 integrin receptor plays an important role in human metastasis and tumor-induced angiogenesis. Targeting this receptor may provide information about the receptor status of the tumor and enable specific therapeutic planning. Solid-phase peptide synthesis of multimeric cyclo(-RGDfE-)-peptides is described, which offer the possibility of enhanced integrin targeting due to polyvalency effects. These peptides contain an aminooxy group for versatile chemoselective oxime ligation. Conjugation with para-trimethylstannylbenzaldehyde results in a precursor for radioiododestannylation, which would allow them to be used as potential tools for targeting and imaging alpha v beta 3-expressing tumor cells. The conjugates were obtained in good yield without the need of a protection strategy and under mild conditions. 相似文献
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Marc Julia Georgette Le Thuillier Lucien Saussine 《Journal of organometallic chemistry》1979,177(1):211-220
α-Chloronitriles are shown to add to α-olefins and conjugated dienes, with ferrous chloride or preferably cuprous chloride in the presence of 2,2′-bipyridyl or 1,10-phenanthroline as catalysts 相似文献
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Castillo-Fernandez O Salieb-Beugelaar GB van Nieuwkasteele JW Bomer JG Arundell M Samitier J van den Berg A Eijkel JC 《Electrophoresis》2011,32(18):2402-2409
The electrokinetic transport behavior of λ-DNA (48 kbp) in 20 nm-high fused-silica nanoslits in the presence of short-chain PVP is investigated. Mobility and video data show a number of phenomena that are typical of DNA transport through gels or polymer solutions, thus indicative of rigid migration obstacles in the DNA pathway. Calculations show that a several nanometer thin layer of wall-adsorbed PVP ('nano-gel') can provide such a rigid obstacle matrix to the DNA. Such ultrathin wall-adsorbed polymer layers represent a new type of matrix for electrokinetic DNA separation. 相似文献
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Rapid synthesis of 1,3,5-substituted 1,2,4-triazoles from carboxylic acids, amidines, and hydrazines
Castanedo GM Seng PS Blaquiere N Trapp S Staben ST 《The Journal of organic chemistry》2011,76(4):1177-1179
A general method for the synthesis of 1,3,5-trisubstituted 1,2,4-triazoles has been developed from reaction of carboxylic acids, primary amidines, and monosubstituted hydrazines. This highly regioselective and one-pot process provides rapid access to highly diverse triazoles. 相似文献
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Marc Julia Lucien Saussine Georgette le Thuillier 《Journal of organometallic chemistry》1979,174(3):359-366
α-Chloroesters add to olefins or dienes under redox catalysis by cuprous chloride in the presence of Bipy or Phen, leading to γ-chloroesters or unsaturated esters. 相似文献
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This paper presents a new heterogeneous multiscale modeling method for porous media flows. Physics at the global level is governed by one set of PDEs, while features in the solution that are beyond the resolution capacity of the global model are accounted for by the next refined set of governing equations. In this method, the global or coarse model is given by the Darcy equation, while the local or refined model is given by the Darcy–Stokes equation. Concurrent domain decomposition where global and local models are applied to adjacent subdomains, as well as overlapping domain decomposition where global and local models coexist on overlapping domains, is considered. An interface operator is developed for the case where global and local models commute along the common interface. For the overlapping decomposition, a residual‐based coupling technique is developed that consistently facilitates bottom‐up embedding of scale effects from the local Darcy–Stokes model into the global Darcy model. Numerical results are presented for nonoverlapping and overlapping domain decompositions for various benchmark problems. Computed results show that the hierarchically coupled models accurately account for the heterogeneity of the medium and efficiently incorporate local features into the global response. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
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Jean Le Men Catherine Caron-Sigaut Georgette Hugel Louisette Le Men-Olivier Jean Lvy 《Helvetica chimica acta》1978,61(2):566-570
Partial Synthesis of (20S)-ψ-Vincamine and (20S)-epi-16ψVincamine An attempt of classification of the indole alkaloids is presented; (20S)-ψ-vincamine. (20S)-16-épi-ψ-vincamine and (20S)-ψ-apo-vincamine have been prepared from catharanthine by partial synthesis. 相似文献
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Under both static and flow thermolysis conditions, several compounds with an “aspidosperma” framework rearranged to “vinca” derivatives. Thus (-)1,2-dehydroaspidospermidine () rearranged to (-) gave vincane . Compound rearranged to vincamine () and 16-epi vincamine () under either condition ; increasing the temperature resulted in formation of apovincamine () (pyrolysis) or vincamone thermolysis). 相似文献
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Thibault Schutz Isaure Sergent Georgette Obeid Laurence Oswald Dr. Abdelaziz Al Ouahabi Dr. Paul N. W. Baxter Dr. Jean-Louis Clément Dr. Didier Gigmes Prof. Laurence Charles Dr. Jean-François Lutz 《Angewandte Chemie (International ed. in English)》2023,62(45):e202310801
A library of phosphoramidite monomers containing a main-chain cleavable alkoxyamine and a side-chain substituent of variable molar mass (i.e. mass tag) was prepared in this work. These monomers can be used in automated solid-phase phosphoramidite chemistry and therefore incorporated periodically as spacers inside digitally-encoded poly(phosphodiester) chains. Consequently, the formed polymers contain tagged cleavable sites that guide their fragmentation in mass spectrometry sequencing and enhance their digital readability. The spacers were all prepared via a seven steps synthetic procedure. They were afterwards tested for the synthesis and sequencing of model digital polymers. Uniform digitally-encoded polymers were obtained as major species in all cases, even though some minor defects were sometimes detected. Furthermore, the polymers were decoded in pseudo-MS3 conditions, thus confirming the reliability and versatility of the spacers library. 相似文献
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