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1.
2.
H. W. Goedde D. Gehring und R. Hofmann 《Fresenius' Journal of Analytical Chemistry》1965,212(1):238-252
Zusammenfassung Es werden verschiedene Methoden zur Differenzierung genetisch bedingter Enzymvarianten der Pseudocholinesterase (spektrophotometrischer Test, Agar-Diffusionstest, Säulenchromatographie), Versuche zur Charakterisierung der verschiedenen Enzymproteine und der in der Stärkegelelektrophorese auftretenden vier Enzymfraktionen mitgeteilt. Ein Reinigungsverfahren für die Pseudocholinesterase wurde ausgearbeitet; nach der Immunisierung von Kaninchen mit dem angereicherten Enzymprotein wurden mit dem gewonnenen Antiserum immunchemische Versuche durchgeführt.
Die in der Literatur am häufigsten zu findende Bezeichnung Pseudocholinesterase wird hier verwendet.
Wir danken der Deutschen Forschungsgemeinschaft, dem Bundesministerium für Wissenschaftliche Forschung und dem Fonds der Chemischen Industrie für ihre Unterstützung. 相似文献
Summary Methods are reported for the differentiation and characterisation of genetically determined enzyme variants and the enzyme fractions occuring in starch-gel electrophoresis of pseudocholinesterase (spectrophotometrical assays, agar diffusion test, column chromatography). A method has been developed to purify the pseudocholinesterase. Rabbits were immunized against a purified enzyme protein. Results of these immuno-chemical assays are given.
Die in der Literatur am häufigsten zu findende Bezeichnung Pseudocholinesterase wird hier verwendet.
Wir danken der Deutschen Forschungsgemeinschaft, dem Bundesministerium für Wissenschaftliche Forschung und dem Fonds der Chemischen Industrie für ihre Unterstützung. 相似文献
3.
W. D. Wu A. Keren L. P. Le G. M. Luke B. J. Sternlieb Y. J. Uemura D. C. Johnston B. K. Cho P. Gehring 《Hyperfine Interactions》1994,86(1):615-621
Muon spin relaxation (SR) studies have been performed in the normal spinel LiTi2O4 and the A-15 superconductor V3Si to measure the magnetic penetration depth . The relaxation rate(T) 1/2 in field-cooled measurements shows a sharp increase belowT
c
followed by saturation at low temperatures in both systems. This feature implies an isotropic energy gap without anomalous zeros, and most likelys-wave pairing. The low temperature penetration depth (T 0) is determined to be 2100Å for LiTi2O4 and 1300Å for V3Si respectively. Assuming a clean limit relation –2 n
s
/m
*, we derive the Fermi temperatureT
F
n
s/
2/3
m
* from the relaxation rate and the Sommerfeld constant asT
F
3/4–1/4. Unlike conventional superconductors, both LiTi2O4 and V3Si have a large ratio ofT
c
/T
F
0.01, only slightly smaller than those ratios in more exotic superconductors.We thank C. Ballard and K. Hoyle for technical assistance. Work at Columbia University is supported by NSF Grant No. DMR-89-13784 and Packard Foundation (YJU). Ames Laboratory is operated for the U. S. Department of Energy by Iowa State University under Contract No. W-7405-Eng-82. Work at Ames was supported by the Director for Energy Research, Office of Basic Energy Sciences. 相似文献
4.
Denisov AY Hannoush RN Gehring K Damha MJ 《Journal of the American Chemical Society》2003,125(38):11525-11531
We have recently shown that hairpins containing 2',5'-linked RNA loops exhibit superior thermodynamic stability compared to native hairpins comprised of 3',5'-RNA loops [Hannoush, R. N.; Damha, M. J. J. Am. Chem. Soc. 2001, 123, 12368-12374]. A remarkable feature of the 2',5'-r(UUCG) tetraloop is that, unlike the corresponding 3',5'-linked tetraloop, its stability is virtually independent of the hairpin stem composition. Here, we determine the solution structure of unusually stable hairpins of the sequence 5'-G(1)G(2)A(3)C(4)-(U(5)U(6)C(7)G(8))-G(9)(U/T(10))C(11)C(12)-3' containing a 2',5'-linked RNA (UUCG) loop and either an RNA or a DNA stem. The 2',5'-linked RNA loop adopts a new fold that is completely different from that previously observed for the native 3',5'-linked RNA loop. The 2',5'-RNA loop is stabilized by (a). U5.G8 wobble base pairing, with both nucleotide residues in the anti-conformation, (b). extensive base stacking, and (c). sugar-base and sugar-sugar contacts, all of which contribute to the extra stability of this hairpin structure. The U5:G8 base pair stacks on top of the C4:G9 loop-closing base pair and thus appears as a continuation of the stem. The loop uracil U6 base stacks above U5 base, while the cytosine C7 base protrudes out into the solvent and does not participate in any of the stabilizing interactions. The different sugar pucker and intrinsic bonding interactions within the 2',5'-linked ribonucleotides help explain the unusual stability and conformational properties displayed by 2',5'-RNA tetraloops. These findings are relevant for the design of more effective RNA-based aptamers, ribozymes, and antisense agents and identify the 2',5'-RNA loop as a novel structural motif. 相似文献
5.
To get informations on both the structure and dynamics of hydrogen chelates 1 of heteroaromatic systems, a great variety of quinazoline-2-acetonitrile chelates were synthesized (see 2–4 ). Similarly to the situation of the corresponding H-chelates in the pyrimidine-2-acetonitrile series, the investigation of these new derivatives 2–4 by NMR spectroscopic methods (DNMR, COSY, NOESY, ROESY, EXSY, HMQC, HMBC) confirms the presence of an equilibrium of the two possible H-chelate structures (two ‘rotamers’ I and II , i.e., (E)/(Z) isomers; see Scheme). The corresponding equilibria I ? II were determined by complete 1H-NMR signal assignment at low temperatures (after freezing the rotational processes). In addition, the tautomer equilibria A ? B (relative energies of the two minima of the nonsymmetrical double-well potential) for both ‘rotamers’ are ascertained by H,H and C,H couplings. The results are an important basis for the interpretation of both the UV/VIS absorptions and the dependence of fluorescence and fluorescence quantum yields on temperature. 相似文献
6.
7.
8.
This paper describes the parallelization of a two-phase metaheuristic for the vehicle routing problem with time windows and a central depot (VRPTW). The underlying objective function combines the minimization of the number of vehicles in the first search phase of the metaheuristic with the minimization of the total travel distance in the second search phase. The parallelization of the metaheuristic follows a type 3 parallelization strategy (cf. Crainic and Toulouse (2001). In F. Glover and G. Kochenberger (eds.). State-of-the-Art Handbook in Metaheuristics. Norwell, MA: Kluwer Academic Publishers), i.e. several concurrent searches of the solution space are carried out with a differently configured metaheuristic. The concurrently executed processes cooperate through the exchange of solutions. The parallelized two-phase metaheuristic was subjected to a comparative test on the basis of 358 problems from the literature with sizes varying from 100 to 1000 customers. The derived results seem to justify the proposed parallelization concept. 相似文献
9.
John W. Moore Kenneth W. Hicks Robert G. Williams Kalle Gehring Sharon Pittinger John R. Vidolich Spencer Schubbe 《Trends in analytical chemistry : TRAC》1983,2(4):74-80
One problem in the use of stopped-flow rapid-mixing systems is that data can be collected much more rapidly than they can be digitized and analyzed. Microprocessor based systems can overcome this problem, but until now they have been expensive and have required experts to assemble the appropriate components. 相似文献
10.