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Bezuglyi P. A. Georgiyants V. A. Perekhoda L. A. Garnaya N. V. Sych I. A. 《Russian Journal of Organic Chemistry》2003,39(4):475-477
By condensation of symmetrical malonic acid diamides with dichloromethane (method a) and with paraform (method b) N,N',N',N'-substituted amides of 1,1,3,3-propanetetracarboxylic acid were synthesized. Better yields of the target products (68-80%) and the use of less toxic reagents indicate that method b is more feasible. The primary pharmacological screening revealed that the compounds obtained possess pronounced anticonvulsant activity at moderate toxicity. 相似文献
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