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1.
Synthesis of nine new benzimidazole derivatives was reported. The products were identified by 1H NMR, mass spectroscopy, and infrared spectroscopy. 相似文献
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Ganta Madhusudhan Reddy V. V. N. K. V. Prasada Raju J. Moses Babu Ch. Praveen Mayur Khunt K. Mukkanti 《合成通讯》2013,43(11):1725-1736
Tenatoprazole (Ulsacare®) is a recently developed antiulcerative drug used for the treatment of both erosive and nonerosive gastroesophageal reflux disease. During the bulk synthesis of tenatoprazole, we have observed four impurities (tenatoprazole N‐oxide, tenatoprazole sulfone N‐oxide, N‐methyl tenatoprazole, and desmethoxy tenatoprazole) and two metabolites (tenatoprazole sulfide and tenatoprazole sulfone). The present work describes the synthesis and characterization of these impurities. 相似文献
3.
Numerical investigation of sound generation due to unsteady laminar flow past elliptic cylinders has been carried out using direct numerical simulation $(DNS)$ approach at a free-stream Mach number of $0.2$. Effects of aspect ratio $(0.6\le AR\le 1.0)$ and Reynolds number $(100\le Re \le 160)$ on the characteristics of radiated sound fields are analyzed. Two-dimensional compressible fluid flow equations are solved on a refined grid using high resolution dispersion relation preserving $(DRP)$ schemes. Using present $DNS$ data, equivalent noise sources as given by various acoustic analogies are evaluated. Amplitudes and frequencies associated with these noise sources are further related to characteristics of disturbance pressure fields. Disturbance pressure fields are intensified with increase in Reynolds number and aspect ratio. Thus, radiated sound power increases with increase in Reynolds number and aspect ratio. Among various cases studied here, minimum and maximum values of radiated sound power are found at $Re=120$ & $AR=0.6$ and $Re=160$ & $AR=1.0$, respectively. Directivity patterns show that the generated sound fields are dominated by the lift dipole for all cases. Next, proper orthogonal decomposition $(POD)$ technique has been implemented for decomposing disturbance pressure fields. The $POD$ modes associated with the lift and the drag dipoles have been identified. $POD$ analyses also clearly display that the radiated sound fields are dominated by the lift dipole only. Further, acoustic and hydrodynamic modes obtained using Doak's decomposition method have confirmed the patterns of radiated sound field intensities. 相似文献
4.
Bhaskar Kandagatla Vetukuri Venkata Naga Kali Vara Prasada Raju Ganta Madhusudhan Reddy Sirigiri Chandrakanth Rao Javed Iqbal Rakeshwar Bandichhor Srinivas Oruganti 《Tetrahedron letters》2012,53(52):7125-7127
Agomelatine was synthesized from 8-aminonaphthalen-2-ol by diazotization-iodination, formylation, C–C bond formation by nitroaldol and Pd/C hydrogenation of β-nitrovinylnaphthalene followed by N-acetylation. The route reported employs readily and commercially viable starting materials and reagents, and can potentially be utilized for process synthesis of agomelatine. 相似文献
5.
Synthesis and Spectral Characterization of Related Substances of Lacidipine,an Antihypertensive Drug
V. V. N. K. V. Prasada Raju Ganta Madhusudhan Reddy Vedantham Ravindra Vijayavitthal T. Mathad P. K. Dubey 《合成通讯》2013,43(12):2137-2145
Five related substances (impurities) were detected in lacidipine bulk drug substance by a simple high-performance liquid chromatographic method (HPLC) and were identified by liquid chromatography–mass spectrometry (LC-MS). These related substances were independently synthesized, characterized, and co-injected with the sample containing impurities. 相似文献
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7.
F Borcan CM Soica S Ganta MM Amiji CA Dehelean O Cerga MF Munteanu 《Chemistry Central journal》2012,6(1):87
ABSTRACT: BACKGROUND: Polymers have been considered as important materials in fabrication of microstructures for various medical purposes including drug delivery. This study evaluates polyurethane as material for hollow microstructures preparation. RESULTS: Polyurethane microstructures were obtained by interfacial polyaddition combined with spontaneous emulsification and present slightly acid pH values. Scanning electron microscopy revealed the existence of irregular shapes and agglomerated microstructures. The material is heat resistant up to 280 [DEGREE SIGN]C. Good results were recorded on murine skin tests in case of polyurethane microstructures based on isophorone diisocyanate. Mesenchymal stem cells viability presents good results for the same sample after 48 hours based on the Alamar Blue test. CONCLUSIONS: The research revealed the reduced noxiousness of this type of microstructures and consequently the possibility of their use for therapeutic purposes. 相似文献
8.
A consecutive three-component coupling reaction involving a lithium di[3-(prop-1-enyltrimethylsilyl)]cuprate, variably substituted ortho-arynes, and a selection of common electrophiles is described. The method affords readily functionalized homobenzylic vinylsilanes with exceptional E-diastereoselectivity and allows for in situ incorporation of carbon- or heteroatom-based electrophiles into the arene. 相似文献
9.
Ashok Ganta Julia L. Shamshina Lauren R. Cafiero Timothy S. Snowden 《Tetrahedron》2012,68(27-28):5396-5405
(R)-Wynberg lactone was used to prepare various asymmetric 2,4-disubstituted butyrolactones in three to four steps. Attainment of any possible stereoisomer, based upon commencement from (R)- or (S)-4-trichloromethyl-2-oxetanone, and the capacity to install disparate substituents at C2 make this approach particularly versatile. 相似文献
10.
Dr. Subhadeep Saha Dr. Yen-Ting Chen Dr. Sudhakar Ganta Markus Gilles Björn Holzapfel Dr. Pascal Lill Prof. Dr. Heinz Rehage Prof. Dr. Christos Gatsogiannis Prof. Dr. Guido H. Clever 《Chemistry (Weinheim an der Bergstrasse, Germany)》2022,28(5):e202103406
Metallo-supramolecular self-assembly has yielded a plethora of discrete nanosystems, many of which show competence in capturing guests and catalyzing chemical reactions. However, the potential of low-molecular bottom-up self-assemblies in the development of structured inorganic materials has rarely been methodically explored so far. Herein, we present a new type of metallo-supramolecular surfactant with the ability to stabilize non-aqueous emulsions for a significant period. The molecular design of the surfactant is based on a heteroleptic coordination cage ( CGA-3 ; CGA =Cage-based Gemini Amphiphile), assembled from two pairs of organic building blocks, grouped around two Pd(II) cations. Shape-complementarity between the differently functionalized components generates discrete amphiphiles with a tailor-made polarity profile, able to stabilize non-aqueous emulsions, such as hexadecane-in-DMSO. These emulsions were used as a medium for the synthesis of spherical metal oxide microcapsules (titanium oxide, zirconium oxide, and niobium oxide) from soluble, water-sensitive alkoxide precursors by allowing a controlled dosage of water to the liquid-liquid phase boundary. Synthesized materials were analyzed by a combination of electron microscopic techniques. In situ liquid cell transmission electron microscopy (LC-TEM) was utilized for the first time to visualize the dynamics of the emulsion-templated formation of hollow inorganic titanium oxide and zirconium oxide microspheres. 相似文献