Novel 2-oxoquinoline-6-sulfonamides as thiazide-like diuretics

A series of novel N-aryl-7-chloro-4-methyl-2-oxo-1,2-dihydroquinoline-6-sulfonamides were obtained. The structure-activity relationship (SAR) approach was used to study their diuretic effect on rats. Diuretic activity was exhibited by all the test compounds, with 7-chloro-4-methyl-2-oxo-1,2-dihydroquinoline-6-sulfonanilide being most active. A SAR analysis revealed that the substituted (especially ortho-substituted in the benzene ring) arylamides diminish diuresis compared to the most active compound. For the most and least active compounds, their effects on the electrolyte excretion (Na⁺, K⁺, and Cl^?) and creatinine level were also studied.     

Organomineral Sorbents Based on Clinoptilolite-Containing Tuffs and Polyethylenimime

Low-swelling sorbent with weakly basic anion-exchange properties was prepared from clinoptilolite-containing tuffs and polyethylenimine using epichlorohydrin cross-linking agent. The properties of this sorbent (total anion-exchange capacity, swellability, etc.) were studied as influenced by the concentrations of the modifying and cross-linking agents, their ratio, period after sorbent preparation, and number of sorption-desorption cycles. The optimal conditions for modifying clinoptilolite-containing tuffs were developed and elemental composition of the resulting sorbent (with respect to C, H, and N) was determined.