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1.
Solid‐state 31P NMR investigation on the status of guanine nucleotides in paclitaxel‐stabilized microtubules
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Ga Hyang Lee Su Young Oh Kwon Joo Yeo Taslima Ferdous Meeyeon Cho Younkee Paik 《Magnetic resonance in chemistry : MRC》2015,53(5):330-336
Microtubule dynamics is a target for many chemotherapeutic drugs. In order to understand the biochemical effects of paclitaxel on the GTPase activity of tubulin, the status of guanine nucleotides in microtubules was investigated by 31P cross‐polarization magic angle spinning (CPMAS) NMR. Microtubules were freshly prepared in vitro in the presence of paclitaxel and then lyophilized in sucrose buffer for solid‐state NMR experiments. A 31P CPMAS NMR spectrum with the SNR of 25 was successfully acquired from the lyophilized microtubule sample. The broadness of the 31P spectral lines in the spectrum indicates that the molecular environments around the guanine nucleotides inside tubulin may not be as crystalline as reported by many diffraction studies. Deconvolution of the spectrum into four spectral components was carried out in comparison with the 31P NMR spectra obtained from five control samples. The spectral analysis suggested that about 13% of the nucleotides were present as GTP and 37% as GDP in the β‐tubulin (E‐site) of the microtubules. It was found that most of the GDPs were present as GDP‐Pi complex in the microtubules, which seems to be one of the effects of paclitaxel binding. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
2.
Howard Anton and Robert C. Busby, John Wiley & Sons, Inc., 2002. 相似文献
3.
4.
A two-fraction model that makes it possible to calculate analytically the complex dielectric permittivity of ice in the far infrared and submillimeter wavelength ranges is proposed. The librational and vibrational fractions are considered. The first fraction, consisting of rigid dipoles executing anharmonic reorientations in defects of the structure, gives rise to the librational band of ice at 800 cm?1. The second fraction consists of elastically vibrating oppositely charged H-bonded molecules. This fraction describes two bands of ice in the range 100–300 cm?1, and the nonresonant background of dielectric losses in the submillimeter wavelength range. The dielectric permittivity spectra of ice calculated for the temperature of ?7°C are consistent with the experimental spectra. The spectra of ice at the temperature ?30°C are predicted. 相似文献
5.
Various approaches and standards for transferring mathematical objects between different computer programs in multimedia environment in the framework of the OpenMath project are described. The use of these standards might revolutionize the exchange of mathematical information caused by the development of computer algebra tools and telecommunication possibilities. The standards make it possible to create databases and easily save and use mathematical objects obtained in different applications, e.g., to exchange the data obtained in different computer algebra systems and place information on the Internet. Bibliography: 9 titles. 相似文献
6.
This paper presents a method to estimate reflected and transmitted wave amplitude spectra in a bounded domain such as a wave tank, when available data signals must be shortened due to interferences and wall effects. This paper extends the well known Goda and Suzuki two-probe method to three probes. The paper also suggests solutions to compute reliable transmission and reflection coefficients in spite of problems linked to higher harmonics and to the interference between different wave trains propagating in the tank. To cite this article: G. Duclos, A.H. Clément, C. R. Mecanique 331 (2003). 相似文献
7.
Gašper Jaklič Jernej Kozak Marjeta Krajnc Vito Vitrih Emil Žagar 《Numerical Algorithms》2007,45(1-4):49-60
In this paper, three-pencil lattices on triangulations are studied. The explicit representation of a lattice, based upon barycentric
coordinates, enables us to construct lattice points in a simple and numerically stable way. Further, this representation carries
over to triangulations in a natural way. The construction is based upon group action of S
3 on triangle vertices, and it is shown that the number of degrees of freedom is equal to the number of vertices of the triangulation.
相似文献
8.
Paweł Grochulski Zdzisław Wawrzak Zdzisław Gałdecki Antoinette Viger Suzy Coustal 《Journal of chemical crystallography》1990,20(5):429-432
The crystal structure of 18-cyanoprogesterone was determined by X-ray diffraction methods:P212121
a=7.436(2),b=11.322(2),c=22.642(2) Å. The structure was solved usingShelx-86. Final conventionalR=0.054.R
w
=0.051 for 1841 reflections. TheA ring has an intermediate sofa-half-chair conformation with asymmetry parameters C
s
/1
=11.0, C
2
3,4
=14.9. The steroid skeleton exhibits a flattening of theA ring relative to the rest of the molecule. The progesterone side chain has a typical conformation, and the C16-C17-C20-O20 torsion angle is –19.0(6)°. 相似文献
9.
M. Kabešová I. Vargová T. Šramko J. Gažo 《Journal of Thermal Analysis and Calorimetry》1978,13(1):65-70
The influence of the position of the CH3 group in picoline and lutidine ligands on the degree of chemical change of the NCS groups in coordination compounds of the type Cu(NCS)2L2 (whereL=2-, 3- and 4-picoline, and 2,3-, 2,4-, 2,5-, 2,6-, 3,4- and 3,5-lutidine) is dealt with. The most marked effect of the CH3 group is found to be exerted in position 4. This effect of the methyl group on the degree of chemical change points to the mutual influence of the ligands in coordination compounds of Cu(II).
Zusammenfassung Der Artikel befaßt sich mit dem Einfluß der Lage der CH3 Gruppe in Pikolinen und Lutidinen als Liganden auf den Grad der chemischen Änderungen der Gruppen NSC in Koordinationsverbindungen des Typs Cu(NCS)2L2 (L=2-, 3- und 4-Pikoline, 2,3-, 2,4-, 2,5-, 2,6-, 3,4- und 3,5-Lutidine). Der ausgeprägteste Effekt der CH3 Gruppe wurde in der Position 4 beobachtet. Dieser Einfluß der Methylgruppe auf das Ausmaß der chemischen Änderungen deutet auch auf die gegenseitige Wirkung der Liganden in Koordinationsverbindungen von Cu(II).
Résumé L'article a trait à l'influence de la position du groupe CH2 dans les picolines et lutidines, en tant que ligands, sur le degré des changements chimiques des groupes SCN dans les composés de coordination du type Cu(SCN)2L2 (L=2-, 3 et 4-picoline, 2,3-, 2,4-,2,5-, 2,6-, 3,4- et 3,6-lutidine). L'effet le plus prononcé du groupe CH3 s'observe en position 4. Cette influence du groupe méthyle sur le degré des changements chimiques indique aussi l'influence mutuelle des ligands dans les composés de coordination du Cu(II).
- , , NCS Cu(NCS)2,L2, L=2-, 3- 4- , 2.3-, 2.4-, 2.5-, 2.6-, 3.4- 3.5-. , 4. Cu(II).相似文献
10.
H. Langfelderová L'. Macášková K. Otrubová J. Gažo 《Journal of Thermal Analysis and Calorimetry》1986,31(5):1143-1151
The thermal decompositions of Cu(en)2(NCS)X. where X–=Cl–, Br–, NO
3
–
, BF
4
–
and ClO
4
–
, have been studied in comparison with the courses of Cu(en)2(SCN)2 and Cu(en)2X2 decomposition. It is shown that the presence of the thiocyanate group in the complexes Cu(en)2(NCS)X is the most important factor in the decomposition course, in agreement with the fact that the anions X– are not coordinated. or are only semicoordinated. Significant differences were found in the courses of thermal decomposition of two forms of Cu(en)2(NCS)(BF4) differing in the structure of their coordination polyhedra.
Zusammenfassung Die thermische Zersetzung von Cu(en)2(NCS)X (X=Cl Br, NO3, BF4 und ClO4) wurde untersucht und mit der von Cu(en2(SCN)2 und Cu(en)2X2 verglichem. Der den Verlauf der Zersetzung entscheidend bestimmende Faktor isi die Anw esenheit der Thiocyanat-Gruppe in den Cu(en)2(NCS)X-Komplexen, was in Übereinstimmung damit steht,. daß die Anionen X nicht oder nur teilweise koordiniert sind. Es wurden signifikante Unterschiedeim Verlauf der thermischen Zersetzung von zwei sich in der Struktur ihrer Kordinationspolyeder unter-, heidenden Formen von Cu(en)2(NCS)(BF4) gefunden.
Cu(en)2(NCS)X (X–=Cl–, Br–, NO 4 – , NO 3 – , BF4 ClO4, Cu(en)2(SCN)2 Cu(en)2(X)2. , Cu(en)2(NCS)X X Cu(en) (NCS)BF4 i .相似文献