Natural time analysis of critical phenomena: The case of acoustic emissions in triaxially deformed Etna basalt

Acoustic emissions exhibit complex correlations between space, time, and magnitude. As such, they present a unique example for a complex time series. We apply the recently introduced method of natural time analysis, which enables the detection of long-range temporal correlations even in the presence of heavy tails and find that the acoustic emissions exhibits features similar to that of other equilibrium or non-equilibrium critical systems such as worldwide seismicity as presented in the Centennial earthquake catalogue which includes global seismicity events with magnitude _Mw>7.0$M_w>7.0$. These results support the universal behaviour of the fracturing processes from the laboratory to the global scale.     

On the non-extensive nature of the isothermal depolarization relaxation currents in cement mortars

The study of isothermal depolarization current relaxation during the cement hardening process follows a generalized exponential function, which explicitly introduces hierarchically constrained dynamics and macroscopic interactions. The interactions are associated to the non-extensive entropy parameter q, which varies during hardening evolution. Combining ideas of Levy and Tsallis statistics we argue that a Levy walk type mechanism can organize the geometry of the cement mortar heterogeneous system. The estimation of non-extensive q parameter safe concludes that cement's hardening is a subextensive process.     

Identification and quantification of glutathione adducts of clozapine using ultra-high-performance liquid chromatography with orthogonal acceleration time-of-flight mass spectrometry and inductively coupled plasma mass spectrometry

The application of sulphur-specific detection via ultra-performance liquid chromatography coupled to inductively coupled plasma mass spectrometry (UPLC/ICPMS) to detect and quantify the glutathione (GSH)-adducts produced via the in vitro formation of reactive metabolites is demonstrated. The adducts were formed in human liver microsomes supplemented with unlabelled GSH for clozapine. The calculation of adduct concentration was performed via comparison of the peak areas to calibration curves constructed from omeprazole, a sulphur-containing compound over the range of 0.156 to 15.62 μM of sulphur with a detection limit of 1.02 ng of sulphur on-column. Identification of the adducts was performed using conventional UPLC/time-of-flight (TOF)-MS with the calculation of clozapine intrinsic clearance carried out by high-performance liquid chromatography/tandem mass spectrometry (HPLC/MS/MS). The use of ICPMS in this way appears to offer a novel, rapid and sensitive means of determining the quantity of GSH conjugates with the combined adducts producing 0.9 μM of reactive metabolite out of a total of 3.5 μM of metabolites. The GSH adduct therefore represents 26% of this total produced as a result of the metabolism of drug to reactive species.     

Combination of molecular rods and half-discs: transition from lamellar to columnar order in multichain mononuclear ortho-palladated metallomesogens

Novel ortho-palladated phenylpyrimidine-1,3-diketonato organyls with successively increasing numbers of alkyl chains were synthesized and investigated by polarizing optical microscopy and X-ray diffraction. A discontinuous transition from a lamellar to a columnar organization is observed, dependent on the number of chains: molecules with four or five chains from smectic phases (SmA, SmC), the related compound with six chains in the molecule is nonmesomorphic, whereas molecules with seven or eight chains form hexagonal columnar mesophases.     

A [24-MC-6] zinc metallacoronate with a nonsteroidal antiinflammatory drug as the constructing ligand

The interaction of ZnCl(2) with 2-dipyridylketonoxime (=Hpko) and flufenamic acid (=Hfluf) in a basic methanolic solution leads to the formation of a hexanuclear 24-membered metallacoronate, [Zn(6)(OH)(2)(pko)(4)(fluf)(6)] (1), with a [Zn-O-C-O] repeat unit and a nonsteroidal antiinflammatory drug as the constructing ligand. Compound 1 retains its structure in a dimethyl sulfoxide solution, as shown by (1)H NMR spectroscopy and molar conductance.     

Is plate tectonics a case of non-extensive thermodynamics?

Bird (2003) [5] proposed that the distribution of areas of the tectonic plates follows a power law and that this distribution fitted well with the concepts of a few major plates and a hierarchical self-similar organization of blocks at the boundary scale, a fractal plate distribution and a self-organized system. Here we apply the concepts of non-extensive statistical mechanics (NESM) to plate tectonics. The application of NESM is appropriate to systems such as tectonic plates where non-linearity, long-range interactions, memory effects and scaling are important. We calculate the probability density function for the areas of the tectonic plates. Our results show that three classes (small, intermediate and large) of tectonic plates can be distinguished, which is consistent with the observations of Bird. Furthermore, taking into account that for the intermediate class of tectonic plates the cumulative frequency distribution behaves as a power law with exponent 1/3, we estimate a thermodynamic q parameter of q=1.75, which supports the conclusion that the plate tectonics system is a sub-extensive one.     

Fractal Dimension of Microbead Assemblies Used for Protein Detection

We use fractal analysis to calculate the protein concentration in a rotating magnetic assembly of microbeads of size 1 μm, which has optimized parameters of sedimentation, binding sites and magnetic volume. We utilize the original Forrest–Witten method, but due to the relatively small number of bead particles, which is of the order of 500, we use a large number of origins and also a large number of algorithm iterations. We find a value of the fractal dimension in the range 1.70–1.90, as a function of the thrombin concentration, which plays the role of binding the microbeads together. This is in good agreement with previous results from magnetorotation studies. The calculation of the fractal dimension using multiple points of reference can be used for any assembly with a relatively small number of particles.     

Temporal patterns in southern Aegean seismicity revealed by the multiresolution wavelet analysis

We applied multiresolution wavelet analysis to the sequence of times between earthquakes occurred between 1970 and 2003 in the southern Aegean area, one of the most seismically active area in the Mediterranean. We observed a twofold features in the wavelet-coefficient standard deviation σ_wav: (i) at low scales it decreases in correspondence with the occurrence of the strongest earthquake, mainly due to the aftershock activation mechanism; (ii) at high scales it is characterized by oscillating behaviour, which is a typical background seismicity.