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1.
J Szeman H Ueda J Szejtli E Fenyvesi Y Machida T Nagai 《Chemical & pharmaceutical bulletin》1987,35(1):282-288
2.
Fenyvesi Éva Nagai Tsuneji Antal Balázs Zsadon Béla Szejtli József 《Journal of inclusion phenomena and macrocyclic chemistry》1984,2(3-4):645-654
Cyclodextrin polymer was compared to other well known disintegrants concerning the swelling properties /water uptake, moisture uptake, hydration capacity, sedimentation volume in water/. Its high disintegrating effect was proved in directly compressed tablets as well as in tablets made by wet granulation. A remarkable improvement in tablet properties was observed. Not only the disintegration of tablets and the dissolution of the drug was accelerated but also the hardness increased when CDP was used as disintegrant. 相似文献
3.
Miyoko Suzuki Éva Fenyvesi Mária Szilasi József Szejtli Márton Kajtár Béla Zsadon Yoshio Sasaki 《Journal of inclusion phenomena and macrocyclic chemistry》1984,2(3-4):715-724
Circular dichroism (CD) and visible spectra of inclusion compounds between Methyl Orange (MO) analogues and -, -, -cyclodextrin (cdx), 2,6-dimethyl-and 2,3,6-trimethyl--cdx, water soluble -, -, -cdx polymer products were investigated. In the CD-spectroscopic investigation, the complex with -cdx epichlorohydrin condensate showed a large amplitude and splitting of the induced * band. Fractions of glyceryl ether of less than 2000 and polymer of more than 10000 dalton molecular mass were separated. Complexes of above two fractions and MO showed the same splitting spectral pattern. Job's plots from visible spectra showed the formation of the 11 complex and CD-data suggested the co-existence of the 21 MO-cdx complex. This splitting pattern showed the reversal of the signs when -cdx-ethyleneglycol-bis(epoxypropyl) ether was used and disappeared when larger host molecules and azo dyes were used. The splitting was explained by exciton interaction. 相似文献
4.
J. Szeman E. Fenyvesi J. Szejtli H. Ueda Y. Machida T. Nagai 《Journal of inclusion phenomena and macrocyclic chemistry》1987,5(4):427-431
The complex forming ability of a water-soluble -cyclodextrin epichlorohydrin, polymer (CDPS) and its different molecular weight fractions was studied and compared with the complexing properties of -cyclodextrin (CD) and dimethyl-CD (DM-CD). CDPS was separated into two main fractions. CDPS and its fractions formed well soluble inclusion compounds with the studied drugs. The low molecular weight fraction formed rather stable complexes with small guest molecules, the high molecular weight fraction was found to be more efficient in binding larger substrates. Structural studies of furosemide-CD complexes were attempted by NMR spectroscopy.Presented at the Fourth International Symposium on Inclusion Phenomena and the Third International Symposium on Cyclodextrins, Lancaster, U.K., 20–25 July 1986. 相似文献
5.
É. Fenyvesi A. Ujházy J. Szejtli S. Potter T. G. Gan 《Journal of inclusion phenomena and macrocyclic chemistry》1996,25(1-3):185-189
Various disinfecting drugs (ethacridine lactate, methylene blue, gentian violet, brilliant green, fuchsin acid, cetylpyridinium chloride) were incorporated into CD bead polymers substituted with carboxymetbyl groups and a retarded release rate was measured. These polymers were successfully used as sustained release wound powders as well as in chewing gum formulations. 相似文献
6.
K. Gruiz É. Fenyvesi É. Kriston M. Molnár B. Horváth 《Journal of inclusion phenomena and macrocyclic chemistry》1996,25(1-3):233-236
Bioavailability and toxic effect of contaminants are the main limitations during soil bioremediation. Cyclodextrins may influence bioavailability of the contaminants during biodegradation and also toxicity of the pollutant on soil microbes and plants since their ability to form inclusion complei with organic compounds. The effect of cyclodextrins on bioremediation and on toxic effect of hydrocarbons was investigated by testing the activity of hydrocarbon degrading microflora and of plant growth. The effect of cyclodextrins could be demonstrated in both cases: biodegradation of hydrocarbons could be enhanced and toxic effect of hydrocarbons on plants and soil microbes could be decreased by adding cyclodextrins. 相似文献
7.
Tibor Cserháti Gyula Oros Éva Fenyvesi József Szejtli 《Journal of inclusion phenomena and macrocyclic chemistry》1984,1(4):395-402
Cross-linked -cyclodextrin with a molecular weight of less than 10000 has good solubility in water, and it is a better inclusion complexing agent than the parent -cyclodextrin. By including lipophilic guest molecules into the apolar cyclodextrin cavity, their apparent lipophilicity is reduced because the outer surface of the molecular wrapping (the crosslinked -CD) is highly hydrophilic. The relative stability of the inclusion complexes can be rapidly determined by reversed-phase thin-layer chromatography. The reversed-phase TLC behaviour of 25 triphenylmethane derivatives and analogues were studied in the presence of -cyclodextrin polymers containing neutral and carboxyl groups. Increasing the molecular weight results in an increased complex-forming capacity. The carboxyl group modifies the accessibility of the CD cavity which in turn results in increased or decreased complex stability, depending on the guest molecule. The presence of organic solvents diminishes the stability of the CD complexes. 相似文献
8.
K. Gruiz M. Moln��r E. Fenyvesi Cs. Hajdu ��. Atk��ri K. Bark��cs 《Journal of inclusion phenomena and macrocyclic chemistry》2011,70(3-4):299-306
Experimental results, which may serve as basis for innovative applications of cyclodextrins (CDs) in environmental technologies, are presented here. Some newly developed CD-aided tools are used in sampling, measuring the concentration or testing the effect of contaminants in water and soil. The innovative methods such as the bacterial bioassays with CD-increased sensitivity or the CD-filled absorptive samplers for air and water sampling are utilised in environmental exposure, hazard and risk assessment. Technological developments aim the reduction of the risk of chemical substances in waters and soils. CD-aided environmental remediation is introduced through examples for the elimination of organic contaminants from water by CD-filters, and for the enhancement of the mobility and availability of soil contaminants in this way increasing the efficiency of soil remediation by water extraction, chemical oxidation, biodegradation, etc. 相似文献
9.
Miyoko Suzuki Yoshio Sasaki József Szejtli Éva Fenyvesi 《Journal of inclusion phenomena and macrocyclic chemistry》1987,5(4):459-468
Low molecular mass fractions of water soluble -, -, and -cyclodextrin epichlorohydrin polymer products (cdx-Ep) were characterized by13C nuclear magnetic resonance. The derivatives proved not to be polymers, but substituted cdx having one or two glyceryl groups per one glucose at the C-2, C-3 and C-6 positions. Spectra of analogous hydroxy-propyl -cdx indicate that the degree of substitution is rather higher at the C-6 position. Methyl orange (MO) was included into nine kinds of cdx having different inner diameters and hydrophobic torus heights; -, -, and -cdx monomers, 2, 6-dimethyl and 2, 3, 6-trimethyl -cdx, water soluble -, -, and -cdx-Ep and ethyleneglycol-bis(epoxy-propyl) ether products. The inclusion shifts were compared with each other and with the dioxane-induced solvent shift of MO. TheN, N-dimethyl-aniline side of MO shifted to a higher field site with the increase of the inner diameter in cdx. By substituting cdx with ether groups of different length, the mechanism of inclusion formation remains substantially the same, but by lengthening the hydrophobic cavity, the hydrophobic interaction becomes stronger, as a better resemblance of inclusion shifts and solvent shifts can be observed.Presented at the Fourth International Symposium on Inclusion Phenomena and the Third International Symposium on Cyclodextrins, Lancaster, U.K., 20–25 July 1986. 相似文献
10.