排序方式: 共有4条查询结果,搜索用时 0 毫秒
1
1.
Peng Haiyue Li Feize Zeng Yang Li Min Liao Jiali Lan Tu Yang Yuanyou Yang Jijun Liu Ning 《Journal of Radioanalytical and Nuclear Chemistry》2021,329(1):289-300
Journal of Radioanalytical and Nuclear Chemistry - A supramolecular organic material MA-IPA containing melamine and isophthalic acid was prepared by low-temperature hydrothermal reaction, with an... 相似文献
2.
Tang Yu Liu Weihao Li Feize Chen Lin Wang Mingshuang Hu Yingjiang Liao Zhonghui Chen Yue Li Shufen Liao Jiali Yang Jijun Yang Yuanyou Liu Ning 《Journal of Radioanalytical and Nuclear Chemistry》2019,322(2):545-551
In this work, the preparation of 111In radiolabeled bleomycin (111In-BLM) was optimized systematically and used for SPECT imaging of liver cancer xenograft models. 111In-BLM with a high radiochemical yield (>?99%) could be obtained at pH 0.5–1 at a mixture ratio of 9:1 (111In/BLM, mCi/mg). The radiochemical purity of 111In-BLM retained?>?99% in either buffers or serum for 3 days. Biodistribution of 111In-BLM revealed its excellent stability in vivo. The SPECT imaging studies showed 111In-BLM has great specificity to liver tumor xenograft. All the results implied 111In-BLM is a potential radiopharmaceutical for targeting diagnosis and therapy of liver tumor.
相似文献3.
Ranxi Liang Zhonghui Liao Dr. Feize Li Huan Ma Weihao Liu Xijian Chen Tu Lan Yuanyou Yang Jiali Liao Jijun Yang Prof. Ning Liu 《Chemistry (Weinheim an der Bergstrasse, Germany)》2022,28(19):e202104589
In past decades, nanoscale metal-organic frameworks (NMOFs) have drawn more and more attention in multimodal imaging and targeting therapy of various malignant cancers. Here, we proposed to dope 111In into fluorescent In-based NMOFs (In-MIL-68-NH2), with an attempt to prepare a new nanomedicine with great anticancer potential. As a proof of concept, the obtained NMOF (In-MIL-68/PEG-FA) with targeting motifs is able to act as a fluorescent probe to achieve Hela cell imaging. Moreover, the Auger electron emitter 111In built in corresponding radioactive NMOF (111In-MIL-68/PEG-FA) can bring clear damage to cancer cells, leading to a high cell killing rate of 59.3 % within 48 h. In addition, the cell cycle presented a significant dose-dependent G2/M inhibiting mode, which indicates that 111In-MIL-68/PEG-FA has the ability to facilitate the cancer cells to enter apoptotic program. This work demonstrated the potential of 111In-labelled NMOFs in specific killings of cancer cells, providing a new approach to develop nanomedicines with theranostic function. 相似文献
4.
陈德胜 刘葳豪 黄清钢 曹石巍 田伟 殷小杰 谈存敏 王洁茹 初剑 贾子萌 程念炜 高瑞勤 吴晓蕾 秦芝 范芳丽 白静 李飞泽 廖家莉 杨远友 刘宁 《化学学报》2021,79(11):1376-1384
211At, 半衰期7.2 h, 发射的α粒子具有很高的线性传能密度, 是一种理想的靶向α治疗核素. 利用中国科学院近代物理研究所强流超导直线加速器提供的α束流辐照Bi靶生产211At, 系统考察了加速器生产211At的整个流程, 包括加速器辐照、干蒸馏分离、质量分析以及单抗标记. 研究结果表明, 干蒸馏分离211At的总收率最高达78.53%, 获得的固体211At产品具有极高的比活度、核纯度以及化学纯度, 其中杂质元素Bi、Cu、Zn、Al含量均低于100 ng/GBq, 且入射粒子能量低于28.2 MeV时, N(210At)/N(211At)值低于10–5, 研究也实现了211At在尼妥珠单抗上的标记, 标记率高达94.86%. 基于以上研究我们确立了一套简单、高效的分离方法, 为后续我国211At的生产和应用奠定了良好基础. 相似文献
1