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1.
ukasz Pecio Asmaa M. Otify Fatema R. Saber Yasser A. El-Amier Moataz Essam Shalaby Solomiia Kozachok Amira K. Elmotayam ukasz
witek Adrianna Skiba Krystyna Skalicka-Wo
niak 《Molecules (Basel, Switzerland)》2022,27(21)
Iphiona mucronata (Family Asteraceae) is widely distributed in the Eastern desert of Egypt. It is a promising plant material for phytochemical analysis and pharmacologic studies, and so far, its specific metabolites and biological activity have not yet been thoroughly investigated. Herein, we report on the detailed phytochemical study using UPLC-Q-TOF-MS approach. This analysis allowed the putative annotation of 48 metabolites belonging to various phytochemical classes, including mostly sesquiterpenes, flavonoids, and phenolic acids. Further, zebrafish embryotoxicity has been carried out, where 100 µg/mL extract incubated for 72 h resulted in a slow touch response of the 10 examined larvae, which might be taken as a sign of a disturbed peripheral nervous system. Results of in vitro testing indicate moderate cytotoxicity towards VERO, FaDu, and HeLa cells with CC50 values between 91.6 and 101.7 µg/mL. However, selective antineoplastic activity in RKO cells with CC50 of 54.5 µg/mL was observed. To the best of our knowledge, this is the first comprehensive profile of I. mucronata secondary metabolites that provides chemical-based evidence for its biological effects. A further investigation should be carried out to precisely define the underlying mechanisms of toxicity. 相似文献
2.
Fatema Bakro Malgorzata Jedryczka Katarzyna Wielgusz Barbara Sgorbini Raffaella Inchingolo Vladimiro Cardenia 《Journal of separation science》2020,43(14):2817-2826
Hemp (Cannabis sativa L.) has become widely used in several sectors due to the presence of various bioactive compounds such as terpenes and cannabidiol. In general, terpenes and cannabidiol content is determined separately, which is time consuming. Thus, a fast gas chromatography with flame ionization detection method was validated for simultaneous determination of both terpenes and cannabidiol in hemp. The method enabled a rapid detection of 29 different terpenes and cannabidiol within a total analysis time of 16 min, with satisfactory sensitivity (limit of detection = 0.03–0.27 µg/mL, limit of quantitation = 0.10–0.89 µg/mL). The inter‐ and intraday precision (RSD) was <7.82 and <3.59%, respectively. Recoveries at two spiked concentration levels (low, 3.15 µg/mL; high, 20.0 µg/mL) were determined on both apical leaves (78.55–101.52%) and inflorescences (77.52–107.10%). The reproducibility (RSD) was <5.94 and <5.51% in apical leaves and inflorescences, respectively. The proposed and validated method is highly sensitive, robust, fast, and accurate for determination of the main terpenes and cannabidiol in hemp and could be routinely used for quality control. 相似文献
3.
Silvana L. Giudicessi M. Kaniz Fatema Hiroshi Nonami Rosa Erra-Balsells 《Journal of the American Society for Mass Spectrometry》2010,21(9):1526-1529
The effect of Ca2+ (and Mg2+) and the disodium salt of ethylenediaminetetraacetic acid (EDTA), a well known Ca2+ (and Mg2+) chelating agent, on the volatilization/ionization of carbohydrates by using electrospray ionization mass spectrometry has
been studied. Model compounds such as maltoses (maltose to maltoheptaose), β-cyclodextrins (β-cyclodextrin, methyl-β-cyclodextrin,
heptakis(2,6-di-O-methyl)-β-cyclodextrin, heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin, and 2-hydroxypropyl-β-cyclodextrin)
and fructans (sucrose, 1-ketose, nystose, and 1F-fructofuranosylnystose) were used. 相似文献
4.
Timothy T. Ho Manisha Gupta Fatema Rezwana Chowdhury Zhijiang Chen Ying Yin Tsui 《Applied physics. B, Lasers and optics》2013,113(3):429-436
Here, we report the fabrication of diamond-like carbon (DLC) thin films using pulsed laser deposition (PLD). PLD is a well-established technique for deposition of high-quality DLC thin films. Carbon tape target was ablated using a KrF (248 nm, 25 ns, 20 Hz) excimer laser to deposit DLC films on soap-coated substrates. A laser fluence between 8.5 and 14 J/cm2 and a target to substrate distance of 10 cm was used. These films were then released from substrates to obtain freestanding DLC thin foils. Foil thicknesses from 20 to 200 nm were deposited using this technique to obtain freestanding targets of up to 1-inch square area. Typically, 100-nm-thick freestanding DLC films were characterized using different techniques such as AFM, XPS, and nano-indentation. AFM was used to obtain the film surface roughness of 9 nm rms of the released film. XPS was utilized to obtain 74 % sp2, 23 % sp3, and 3 % C–O bond components. Nano-indentation was used to characterize the film hardness of 10 GPa and Young’s modulus of 110 GPa. Damage threshold properties of the DLC foils were studied (1,064 nm, 6 ns) and found to be 7 × 1010 W/cm2 peak intensity for our best ultrathin DLC foils. 相似文献
5.
Saba Fatema Mohammad Hassan Murad 《International Journal of Theoretical Physics》2013,52(7):2508-2529
This paper presents a family of two-parametric interior solutions of Einstein–Maxwell field equations in general relativity for a static spherically symmetric distribution of a charged perfect fluid with particular choice of charge distribution and the metric component g 00. This family gives us wide range of parameters, n and K, for which the solutions are regular and acceptable on physical grounds and hence suitable for modeling of charged compact star. The maximum allowable mass and corresponding radius, for this family of solutions with the particular form of charge distribution, is determined to be 2.48M ⊙ and 10.56 km respectively by assuming the stellar “surface” density equal to strange (quark) matter density at zero pressure. It is hoped that our investigation may be of some importance in connection with the study of internal structure of electrically charged strange (quark) star. 相似文献
6.
Mohammad Hassan Murad Saba Fatema 《International Journal of Theoretical Physics》2013,52(12):4342-4359
In continuation of recent work done by the present authors (Int. J. Theor. Phys. 2013, doi:10.1007/s10773-013-1538-y, hereafter paper I) some new exact families of static spherically symmetric perfect fluid solution of Einstein–Maxwell gravitational field equations are presented. These solutions and the corresponding equations of state, presented in parametric form, may be astrophysically significant in constructing relativistic stellar models of electrically charged self-bound stars. 相似文献
7.
Taher Alizadeh Fatema Rezaloo 《International journal of environmental analytical chemistry》2013,93(8):919-934
In this work, the application of molecularly imprinted polymer (MIP) as the recognition element of a chemiresistor sensor was introduced. Toluene-imprinted polymer and non-imprinted polymer (NIP) were synthesized and then mixed with carbon black powder in the presence of melted n-eicosane as the binder agent. The obtained composites were applied for the construction of chemiresistor sensors. The sensor, fabricated with toluene-imprinted polymer, showed a significant response towards toluene. Moreover, the response of the NIP-based (polymer synthesized without solvent) chemiresistor sensor was very small and negligible. The components of the MIP-based sensing composite were found to strongly influence the sensor sensitivity. Response surface experimental design methodology was applied to optimize the important parameters of the proposed sensor. Cross-sensitivity of the MIP-based chemiresistor sensor for different vapours was investigated and a satisfactory result was found for toluene vapour recognition. It was shown that the sensor response to toluene concentration in air was linear in the concentration range of 3.8 to 46.4?ppm. The detection limit and relative standard deviation (for five separate determinations) of the designed sensor were calculated equal to 0.8?ppm and 5.6%, respectively. 相似文献
8.
Shishir Ghosh Kaniz Fatema Md. Rafique Al-Mamun Graeme Hogarth 《Journal of organometallic chemistry》2011,696(18):2935-2942
Reaction of [Mn2(CO)9(NCMe)] with tetrahydropyrimidine-2-thione (thpymSH) at 25 °C furnishes the mono- and dinuclear complexes [Mn(CO)4(κ1:η1-SCNHC3H6NCO)] (2) and [Mn2(CO)6(μ-thpymS)2] (1), respectively. Carbon-nitrogen coupling is observed in compound 2 resulting in the formation of κ1:η1-SCNHC3H6NCO ligand while compound 1 adopts a centrosymmetric structure. Reaction of 1 with [Os3(CO)10(NCMe)2] at 80 °C affords the mixed Mn-Os cluster [MnOs3(CO)13(μ3-thpymS)] (3) which possesses a butterfly skeleton of four metal atoms whereas with Ru3(CO)12 at 110 °C gives the mixed Mn-Ru complex [MnRu3(CO)14(μ4-S)(κ1:η1-thpym)] (4). In contrast, treatment of 1 with Fe3(CO)12 at 80 °C furnishes two triiron complexes [Fe3(CO)9(μ3-S)(μ3-κ1:η1-C4H6N2)] (5) and [Fe3(CO)8(μ3-S)2(η1-C4H8N2)] (6). The former also results from the direct reaction of thpymSH with Fe3(CO)12 and reacts with H2S to afford 6. The molecular structures of all these new complexes have been determined by X-ray diffraction studies. 相似文献
9.
Fatema Ahmmed Daniel P. Killeen Keith C. Gordon Sara J. Fraser-Miller 《Molecules (Basel, Switzerland)》2022,27(14)
This study uses Raman and IR spectroscopic methods for the detection of adulterants in marine oils. These techniques are used individually and as low-level fused spectroscopic data sets. We used cod liver oil (CLO) and salmon oil (SO) as the valuable marine oils mixed with common adulterants, such as palm oil (PO), omega-3 concentrates in ethyl ester form (O3C), and generic fish oil (FO). We showed that support vector machines (SVM) can classify the adulterant present in both CLO and SO samples. Furthermore, partial least squares regression (PLSR) may be used to quantify the adulterants present. For example, PO and O3C adulterated samples could be detected with a RMSEP value less than 4%. However, the FO adulterant was more difficult to quantify because of its compositional similarity to CLO and SO. In general, data fusion improved the RMSEP for PO and O3C detection. This shows that Raman and IR spectroscopy can be used in concert to provide a useful analytical test for common adulterants in CLO and SO. 相似文献
10.
Manisha Gupta Fatema Rezwana Chowdhury Douglas Barlage Ying Yin Tsui 《Applied Physics A: Materials Science & Processing》2013,110(4):793-798
In this work we present the optimization of zinc oxide (ZnO) film properties for a thin-film transistor (TFT) application. Thin films, 50±10 nm, of ZnO were deposited by Pulsed Laser Deposition (PLD) under a variety of growth conditions. The oxygen pressure, laser fluence, substrate temperature and annealing conditions were varied as a part of this study. Mobility and carrier concentration were the focus of the optimization. While room-temperature ZnO growths followed by air and oxygen annealing showed improvement in the (002) phase formation with a carrier concentration in the order of 1017–1018/cm3 with low mobility in the range of 0.01–0.1 cm2/V?s, a Hall mobility of 8 cm2/V?s and a carrier concentration of 5×1014/cm3 have been achieved on a relatively low temperature growth (250 °C) of ZnO. The low carrier concentration indicates that the number of defects have been reduced by a magnitude of nearly a 1000 as compared to the room-temperature annealed growths. Also, it was very clearly seen that for the (002) oriented films of ZnO a high mobility film is achieved. 相似文献