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1.
Research on Chemical Intermediates - The activity of glycine max leaves extract against corrosion of mild steel in 0.5 M HCl solution has been investigated at different temperatures... 相似文献
2.
Journal of Radioanalytical and Nuclear Chemistry - Uranium is carcinogenic ion and if present in water above its permissible limit, is very harmful to living beings. The main objective of this... 相似文献
3.
Rabia Javeed Dilshad Hussain Fahmida Jabeen Adeela Saeed Batool Fatima Muhammad Naeem Ashiq Muhammad Najam-ul-Haq 《Biomedical chromatography : BMC》2020,34(1):e4693
High-density lipoproteins (HDLs) have anti-inflammatory and antioxidant properties and are potentially cardio-protective. Defective HDL function is caused by alterations in both the proteome and lipidome of HDL particles. As potential biomarkers, the development of analytical methods is necessary for the enrichment of HDLs. Therefore, a method for selective enrichment of HDLs using immobilized metal ion affinity chromatography (IMAC) and metal oxide affinity chromatography (MOAC) is presented. SPE-based isolation of HDLs from whole serum is adopted as an alternative to traditional ultracentrifugation methods followed by SDS–PAGE. The enrichment mechanism relies on isoelectric points of lipoproteins and metal oxide. Negatively charged lipoprotein particles interact with positively charged metal oxides and IMAC affinity, which acts as a cation. Identified proteins from HDL through MALDI–MS analysis are apo AI, AII, AIV, CI, CIII, E, J, M, H, serum amyloid A and other nonapoproteins that are part of HDL particles and perform cellular functions. This serum-based proteomics approach gives insight into the functional role of HDL. HDL-associated phospholipids have also been analyzed by LDI–MS. Results suggest that the adopted analytical strategy is a feasible idea to extract lipoproteins from serum. A comparative study of healthy and diseased samples using this approach will provide valuable information in future. 相似文献
4.
Maheswata Moharana Anuradha Das Satya Narayan Sahu Subrat Kumar Pattanayak Fahmida Khan 《印度化学会志》2022,99(4):100417
Phytochemicals present in medicinal plants have a variety of biological activities that help to combat against diseases. As part of efforts to study the binding performance of different phytochemicals derived from different plants like Zingiber officinale, Citrus limon, Syzygiumaromaticum, Ocimum tenuiflorum and Curcumin. We have screened 424 molecules. The binding affinity as well as physicochemical properties of the thebaine, acacetin, indomethacin, crinamineacetate, (S)-1-Piperideine-6-carboxylate, levamisole, melatonin, nicotinicacid, curcumin, methotrimeprazine, omeprazole, and methaqualone phytocompounds were analyzed through computational study. From the molecular docking study we found that, LEU50, ASN72, PRO96, TYR154, GLY170, ALA193, ARG222, and MET274 residues of main protease play a crucial role in binding with ligands. The present study revealed a noticeable interaction of GLY446, SER477, GLY482, THR500 and LEU518 residues with mutant of spike receptor binding domain SARS-CoV-2 protein were observed. Finally, 100 ns molecular dynamics simulation were used to study their dynamic properties as well as conformational flexibility. Free energy landscape analysis was performed of the 6LU7- acacetin and 6Y2E-acacetin systems and spike RBD-acacetin system. From molecular docking study and molecular dynamics study revealed that, the compound acacetin shows promising inhibitor towards both main protease as well as mutant spike RBD of SARS-CoV-2 protein. 相似文献
5.
S. Ganesh Fahmida Khan M. K. Ahmed Shashikrishna Pandey 《Journal of Radioanalytical and Nuclear Chemistry》2010,286(1):33-37
A simple analytical procedure for the sequential determination of uranium (IV), free acidity and hydrazine in presence of
hydrolysable ions is developed and described. In this method, first, uranium (IV) is determined using fiber optic aided spectrophotometry
then same solution is used for determination of free acidity and hydrazine. Free acid is titrated with standard sodium carbonate
solution after uranium (IV) is masked with EDTA. Once the end point for the free acid is determined at pH 3.0, an aliquot
of formaldehyde is added to liberate the acid equivalent to hydrazine which is then titrated with the same standard sodium
carbonate solution using an automatic titration system. The described method is simple, accurate and reproducible. The overall
recovery of uranium (IV), nitric acid and hydrazine is 98% with 3% relative standard deviation respectively. The major advantage
of the method is that it uses sodium carbonate a primary standard as titrant and generation of corrosive analytical wastes
containing oxalate or sulphate is avoided. Valuable metals like uranium and plutonium can easily be recovered from analytical
waste before final disposal. 相似文献
6.
Dilshad Hussain Muhammad Najam-ul-Haq Fahmida Jabeen Muhammad N. Ashiq Muhammad Athar Matthias Rainer Christian W. Huck Guenther K. Bonn 《Analytica chimica acta》2013
Diamond is known for its high affinity and biocompatibility towards biomolecules and is used exclusively in separation sciences and life science research. In present study, diamond nanopowder is derivatized as Immobilized Metal Ion Affinity Chromatographic (IMAC) material for the phosphopeptides enrichment and as Reversed Phase (C-18) media for the desalting of complex mixtures and human serum profiling through MALDI-TOF-MS. Functionalized diamond nanopowder is characterized by Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) spectroscopy. Diamond-IMAC is applied to the standard protein (β-casein), spiked human serum, egg yolk and non-fat milk for the phosphopeptides enrichment. Results show the selectivity of synthesized IMAC-diamond immobilized with Fe3+ and La3+ ions. To comprehend the elaborated use, diamond-IMAC is also applied to the serum samples from gall bladder carcinoma for the potential biomarkers. Database search is carried out by the Mascot program (www.matrixscience.com) for the assignment of phosphorylation sites. Diamond nanopowder is thus a separation media with multifunctional use and can be applied to cancer protein profiling for the diagnosis and biomarker identification. 相似文献
7.
Dewangan Pradeep Kumar Khan Fahmida Shrivas Kamlesh Sahu Vinayak 《Journal of Radioanalytical and Nuclear Chemistry》2019,320(3):757-763
Journal of Radioanalytical and Nuclear Chemistry - The unique properties of graphene quantum dots (GQDs) i.e. low toxicity, excellent water solubility, low cost, high photostability,... 相似文献
8.
Mg-doped zinc oxide and zinc oxide nanoparticles were prepared by using methanolic seed extract from the Eucalyptus grandis plant via a green approach. Phytoconstituents present in seed extract act as capping and stabilizing agents for the biosynthesis of nanoparticles. Doping of Mg to zinc oxide nanoparticles increases the bandgap energy, thus enhancing its chemical, physical and optical properties. Further, it was characterized by various techniques such as scanning electron microscopy giving morphological information about the wurtzite hexagonal structure of bio-synthesized nanoparticles. X-ray diffraction technique tells about the crystalline nature of particles and the average crystallite size for zinc oxide and doped zinc oxide nanoparticles. Mg as a dopant enhances the properties of nanoparticles, thus making it more efficiently applicable as an antibacterial agent against Escherichia coli, gram-negative bacteria. 相似文献
9.
Mohd Adnan Kausar Sadaf Anwar Wafa Ali Eltayb Mohammed Kuddus Fahmida Khatoon Amr Ahmed El-Arabey Amany Mohammed Khalifa Moattar Raza Rizvi Mohammad Zeeshan Najm Lovnish Thakur Subhabrata Kar Mohnad Abdalla 《Molecules (Basel, Switzerland)》2022,27(15)
Diabetes is emerging as an epidemic and is becoming a public health concern worldwide. Diabetic nephropathy is one of the serious complications of diabetes, and about 40% of individuals with diabetes develop diabetic nephropathy. The consistent feature of diabetes and its associated nephropathy is hyperglycemia, and in some cases, hyperamylinemia. Currently, the treatment includes the use of medication for blood pressure control, sugar control, and cholesterol control, and in the later stage requires dialysis and kidney transplantation, making the management of this complication very difficult. Bioactive compounds, herbal medicines, and extracts are extensively used in the treatment and prevention of several diseases, and some are reported to be efficacious in diabetes too. Therefore, in this study, we tried to identify the therapeutic potential of phytochemicals used in in silico docking and molecular dynamic simulation studies using a library of 5284 phytochemicals against the two potential targets of type 2 diabetes-associated nephropathy. We identified two phytochemicals (i.e., gentisic acid and michelalbine) that target human amylin peptide and dipeptidyl peptidase-4, respectively, with good binding affinity. These phytochemicals can be further evaluated using in vitro and in vivo studies for their anti-hyperglycemia and anti-hyperamylinemia effects. 相似文献
10.
S. Ganesh Fahmida Khan M. K. Ahmed P. Velavendan N. K. Pandey U. Kamachi Mudali S. K. Pandey 《Journal of Radioanalytical and Nuclear Chemistry》2012,292(1):331-334
A simple and rapid, laser fluorimetric method for the determination of uranium concentration in raffinate stream of Purex
process during reprocessing of spent nuclear fuel has been developed. It works on the principle of detection of fluorescence
of uranyl complex formed by using fluorescence enhancing reagent like sodium pyrophosphate. The uranium concentration was
determined in the range of 0–40 ppb and detection limit of 0.2 ppb. The optimum time discrimination is obtained when the uranyl
ion is complexed with sodium pyrophosphate. Need of preconcentration step or separation of uranium from interfering elements
is not an essential step. 相似文献