排序方式: 共有1条查询结果,搜索用时 31 毫秒
1
1.
LI Lin CHONG Wesley K.M DUVADIE Rohit K CHU Shao Song YANG Y.Michelle NONOMIYA Jim TUCKER Kadthleen D KNIGHTON Daniel R FERRE RoseAnn LUNDGREN Karen ESCOBAR Jorge MINNICK Sharon price HUBER Andrea KOUDRIAKOVA Tatiana ARRUDA Jeannie SISSON Wes AUST Robert M VERKHIVKER Gennady M SCHAFFER Lana ROSE Peter w LEWIS Cristrina T 《高等学校化学研究》2001,17(3)
Control of the cell cycle could be applicable in new approaches for cancer chemotherapy. The cyclin-dependent kinases (CDK's) and their corresponding complexes with cyclins are regulatory enzymes for which we have discovered a novel small molecule series of inhibitors, with potencies in the nanomolar range and good selectivity for the CDK's versus other kinases. We will discuss structure-based drug design efforts with crystal structures of complexes with certain CDK's. Cellular effects and some preliminary examination of in vivo cancer efficacy by these inhibitors will also be discussed. 相似文献
1