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Synthesis and in vitro antimicrobial screening of new pyrano[4,3-b]pyrane derivatives of 1H-pyrazole
A new series of pyrano[4,3-b]pyrane 4a-l bearing 1H-pyrazole has been synthesized by one pot base catalyzed cyclocondensation reaction of 1H-pyrazole-4-carbaldehyde la-1,malononitrile 2 and 4-hydroxy-6-methylpyrone 3.All the synthesized compounds were screened against six bacterial pathogens,namely B.subtilis,C.tetani,S.pneumoniae,S.typhi,V.cholerae, E.coli and antifungal activity against,two fungal pathogens,A.fumigatus and C.albicans using broth microdilution MIC method. Some of the compounds are found to be equipotent or more potent than that of commercial drugs,against most of employed strains. 相似文献
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Formation and Structural Characterization of Metal Complexes derived from Thiosalicylic Acid 下载免费PDF全文
Minu G. Bhowon Sabina Jhaumeer‐Laulloo Salma Moosun Lisa Humphreys Simon Coles Roshni Fowdram Evena Mungra 《无机化学与普通化学杂志》2017,643(18):1167-1172
The formation and structural aspects of some metal complexes of thiosalicylic acid (TSA) were studied. The μ‐bridging tetra‐coordinated Ru complex, [Ru(C6H4(CO2)(μ‐S)(H2O)]2 ( 1 ) was formed by hydrothermal reaction of TSA with RuCl3. The complexes [M(dtdb)(phen)(H2O)]n ( 2 – 4 ) (M = ZnII, CoII, NiII, dtdb = 2,2′‐dithiodibenzoate anion, phen = 1,10‐phenanthroline) were obtained by the slow diffusion technique and the in situ S–S bond formation was confirmed by elemental, spectral and X‐ray analysis. Reaction of TSA with CuCl2 and 2,2′‐bipyridine (bipy) under the slow diffusion technique yielded the dimer [Cu(tdb)(bipy)] ( 5 ) (tdb = thiodibenzoic acid), where the in situ generation of 2,2′‐thiodibenzoic acid was observed. 相似文献
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Chetan B. Sangani Divyesh C. Mungra Manish P. Patel Ranjan G. Patel 《Central European Journal of Chemistry》2011,9(4):635-647
A new series of twenty four derivatives of pyrano[3,2-c]chromene IVa-x bearing 1H-pyrazole were synthesized by a one pot, base-catalyzed cyclocondensation reaction of 1H-pyrazole-4-carbaldehyde Ia-l, malononitrile II and 4-hydroxycoumarin IIIa-b. All the synthesized compounds were characterized by elemental analysis, FT-IR, 1H NMR and 13C NMR spectral data. All the synthesized compounds were screened against six bacterial pathogens, namely B. subtilis, C. tetani, S. pneumoniae, S. typhi, V. cholerae, E. coli and for antifungal activity against two fungal pathogens, A. fumigatus and C. albicans using the broth microdilution MIC method. Some of the compounds were found to be equipotent or more potent than commercial
drugs against most of employed strains, as evident from the screening data.
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In matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS), the analysis capability, especially for small molecules, is often compromised by the addition of organic matrices due to the existence of background signals. Herein we report a new detection method on the utility of core-shell nanoparticles (CSNPs) as energy transfer structure in LDI-TOF-MS. The LDI-TOF-MS based on gold-silica core-shell nanoparticles with ultrathin silica shell of 2-4 nm (Au@utSiO(2) CSNPs) was effectively applied to the analysis of many compounds, especially for small functional molecules and polymers, which was more promising than MALDI-TOF-MS. 相似文献
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Divyesh C.Mungra Harshad G.Kathrotiya Niraj K.Ladani Manish P.Patel Ranjan G.Patel 《中国化学快报》2012,23(12):1367-1370
A series of some new tetrazolo[1,5-a]quinoline based tetrasubstituted imidazole derivatives 6a-1 have been synthesized by a reaction of tetrazolo[1,5-a]quinoline-4-carbaldehyde 3a-d,benzil 4,aromatic amine 5a-c and ammonium acetate in the presence of iodine through one-pot multi-component reaction(MCR) approach.All the derivatives were screened for antimicrobial and antituberculosis activities and results worth further investigations. 相似文献
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Microwave assisted efficient Hantzsch reaction via four-component coupling reactions of tetrazolo[1,5-α]quinoline-4-carbal-dehyde, dimedone/cyclohexane-1,3-dione,ethyl/methyl acetoacetate and ammonium acetate was described as the preparation of tetrazolo[1,5-α]quinoline based 1,4-dihydropyridines,acridine-1,8-diones and polyhydroquinolines.The process presented here is simple,rapid,environmentally welcoming and high yielding.All the derivatives were subjected to an in vitro antimicrobial screening against a representative panel of bacteria and fungi and results worth further investigations. 相似文献
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